|
| Status |
Public on May 25, 2014 |
| Title |
The effect of Crem absence on gene expression in mouse adrenal glands. |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
|
| Summary |
CREM (cAMP responsive element modulator) together with CREB and ATF-1 belong to the CREB family of transcriptional factors, that respond to cyclic AMP signaling and bind to cAMP responsive element (CRE) sites in promoters of selected genes. CREM can produce isoforms that have either activating or repressing functions, depending on the transcription of specific exons. In adrenal glands it is involved in the regulation of expression of genes for steroid hormone synthesis.
In this dataset, we include the expression data obtained from wild-type and Crem knock-out mouse adrenal glands.
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| |
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| Overall design |
2 condition experiment: 2 strains (WT, Crem-/-). 5 biological replications per condition.
|
| |
|
| Contributor(s) |
Košir R, Juvan P, Perše M, Majdič G, Fink M, Rozman D |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| |
| Submission date |
May 27, 2011 |
| Last update date |
Mar 04, 2019 |
| Contact name |
Peter Juvan |
| Phone |
+386 1 543 7595
|
| Organization name |
Faculty of Medicine, University of Ljubljana
|
| Department |
Institute of Biochemistry
|
| Lab |
Center for Functional Genomics and Bio-Chips
|
| Street address |
Zaloska 4
|
| City |
Ljubljana |
| ZIP/Postal code |
SI-1000 |
| Country |
Slovenia |
| |
|
| Platforms (1) |
| GPL6246 |
[MoGene-1_0-st] Affymetrix Mouse Gene 1.0 ST Array [transcript (gene) version] |
|
| Samples (10)
|
| GSM732627 |
Adrenal CREMKO 0h batch 1 [AdKOh00.1] |
| GSM732628 |
Adrenal WT 0h batch 1 [AdWTh00.4] |
| GSM732629 |
Adrenal CREMKO 0h batch 1 [AdKOh00.8] |
| GSM732630 |
Adrenal CREMKO 0h batch 2 [AdKOh00.15] |
| GSM732631 |
Adrenal CREMKO 0h batch 2 [AdKOh00.16] |
| GSM732632 |
Adrenal CREMKO 0h batch 3 [AdKOh00.18] |
| GSM732633 |
Adrenal WT 0h batch 3 [AdWTh00.19] |
| GSM732634 |
Adrenal WT 0h batch 3 [AdWTh00.22] |
| GSM732635 |
Adrenal WT 0h batch 3 [AdWTh00.23] |
| GSM732636 |
Adrenal WT 0h batch 4 [AdWTh00.26] |
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| This SubSeries is part of SuperSeries: |
| GSE29595 |
The effect of Crem absence on gene expression in mouse |
|
| Relations |
| BioProject |
PRJNA153835 |
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