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| Status |
Public on Feb 07, 2012 |
| Title |
Innate response activator B cells are sentinels that guard against polymicrobial sepsis |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
Innate immunity is fundamental to recognition and clearance of bacterial infection. The relevant cells and molecules that orchestrate an effective response, however, remain incompletely understood. Here we describe a previously unknown population of B cells, which we have named innate response activator (IRA) B cells that recognize bacteria directly through TLR-4-MyD88 and protect against polymicrobial sepsis.
IRA-B cells have a unique IgM high CD23 low CD43 + CD93+ GM-CSF+ signature, develop and diverge from B1a B cells, require BAFFR, and adhere to tissue via VLA-4 and LFA-1.
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| Overall design |
B cell subsets are sorted from the spleen and peritoneum of C57BL/6 mice that were given intraperitoneal injections of LPS once daily for four days.
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| Contributor(s) |
Rauch PJ, Chudnovskiy A, Robbins CS, Weber GF, Etzrodt M, Hilgendorf I, Figueiredo J, Iwamoto Y, Gorbatov R, Mouded M, Pittet M, Nahrendorf M, Weissleder R, Swirski FK |
| Citation(s) |
22245738 |
| |
| Submission date |
Sep 26, 2011 |
| Last update date |
Jun 14, 2018 |
| Contact name |
Martin Etzrodt |
| E-mail(s) |
[email protected], [email protected]
|
| URL |
http://csb.mgh.harvard.edu/filip_swirski
|
| Organization name |
Massachusetts General Hospital
|
| Department |
Center for Systems Biology
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| Lab |
Swirski
|
| Street address |
185 Cambridge St
|
| City |
Cambridge |
| State/province |
MA |
| ZIP/Postal code |
02114 |
| Country |
USA |
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| Platforms (1) |
| GPL6885 |
Illumina MouseRef-8 v2.0 expression beadchip |
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| Samples (21)
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| Relations |
| BioProject |
PRJNA147973 |
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