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GEO help: Mouse over screen elements for information. |
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| Status |
Public on Feb 27, 2012 |
| Title |
The alarmin interleukin-33 drives protective antiviral CD8+ T cell responses |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
Pathogen-associated molecular patterns decisively influence antiviral immune responses, whereas the contribution of endogenous signals of tissue damage, also known as “damage-associated molecular patterns” or “alarmins”, remains ill-defined. We show that interleukin-33 (IL-33), an alarmin released from necrotic cells, is necessary for potent CD8+ T cell (CTL) responses to replicating, prototypic RNA and DNA viruses in mice. IL-33 signaled through its receptor on activated CTLs, enhanced clonal expansion in a MyD88-dependent, CTL-intrinsic fashion, determined polyfunctional effector cell differentiation and was necessary for virus control. Moreover, recombinant IL-33 augmented vaccine-induced CTL responses. Radio-resistant cells of the splenic T cell zone produced IL-33, and efficient CTL responses required IL-33 from radio-resistant cells but not from hematopoietic cells. Thus, alarmin release by radio-resistant cells orchestrates protective antiviral CTL responses.
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| Overall design |
2 groups (wt vs. ST-/- P14 cells), 3 replicates per group.
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| Contributor(s) |
Bonilla WV, Fröhlich A, Senn K, Kallert S, Fernandez M, Johnson S, Kreutzfeldt M, Hegazy AN, Schrick C, Fallon PG, Klemenz R, Nakae S, Adler H, Merkler D, Löhning M, Pinschewer DD |
| Citation(s) |
22323740 |
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| Submission date |
Dec 12, 2011 |
| Last update date |
Mar 04, 2019 |
| Contact name |
Sandra Kallert |
| E-mail(s) |
[email protected]
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| Phone |
+41223795993
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| Organization name |
University of Geneva
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| Department |
Pathology and Immunology
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| Street address |
1, rue Michel-Servet
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| City |
Geneva |
| ZIP/Postal code |
1211 |
| Country |
Switzerland |
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| Platforms (1) |
| GPL6246 |
[MoGene-1_0-st] Affymetrix Mouse Gene 1.0 ST Array [transcript (gene) version] |
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| Samples (6)
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| Relations |
| BioProject |
PRJNA149569 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE34392_RAW.tar |
27.0 Mb |
(http)(custom) |
TAR (of CEL, CHP) |
| Processed data included within Sample table |
| Processed data provided as supplementary file |
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