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| Status |
Public on Sep 30, 2014 |
| Title |
Gene expression data comparing rbf1 mutant and PSC overexpressing Drosophila eye imaginal discs |
| Organism |
Drosophila melanogaster |
| Experiment type |
Expression profiling by array
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| Summary |
PSC overexpression can cause phenotypes specifically in an rbf1 mutant background, likely due to a sensitization to PSC-induced phenotypes. The goal of this study is to understand the interaction between rbf1 hypomorphic mutation and the overexpression of Polycomb group gene Posterior sex combs. We used Drosophila larval eye imaginal discs that were mutant for rbf1 or overexpressing PSC and compared these to control larval eye discs to assess changes in gene expression.
We identified a common set of genes that are deregulated when rbf1 is mutated or when PSC is overexpressed.
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| Overall design |
RNA was extracted from eye imaginal discs dissected from third instar Drosophila larvae. Samples were amplified and hybridized to Affymetrix Drosophila Genome 2.0 Array. To better understand the effects of rbf1 mutation and PSC overexpression, we compared the gene expression of rbf1 mutant eye discs and eye discs overexpressing PSC to control eye discs.
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| Contributor(s) |
Collins H, Moon N |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| |
| Submission date |
Jun 03, 2012 |
| Last update date |
May 04, 2018 |
| Contact name |
Heather Collins |
| E-mail(s) |
[email protected]
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| Organization name |
McGill University
|
| Department |
Biology
|
| Lab |
Nam-Sung Moon
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| Street address |
1205 Docteur Penfield Avenue
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| City |
Montreal |
| State/province |
Quebec |
| ZIP/Postal code |
H3A 1B1 |
| Country |
Canada |
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| Platforms (1) |
| GPL1322 |
[Drosophila_2] Affymetrix Drosophila Genome 2.0 Array |
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| Samples (9)
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| Relations |
| BioProject |
PRJNA167839 |
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