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| Status |
Public on Jun 15, 2013 |
| Title |
IL-17 and TNF synergistically induce growth-associated cytokines in melanocytes while suppressing melanogenesis |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
In this study, we sought to determine how IL-17 and TNF influence normal human melanocytes, either alone, or with both cytokines together. We reveal a dichotomous effect of IL-17 and TNF, which not only elicit essential mitogenic cytokines but also suppress melanogenesis by down-regulating genes of melanogenesis pathway
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| Overall design |
Comparison of one batch of primary human melanocyte line cultured in serum free media, treated with TNF and/or IL-17, for either 24 or 48 hours.
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| Contributor(s) |
Wang CQ, Suárez-Fariñas M, Krueger JG |
| Citation(s) |
23732752 |
| |
| Submission date |
Aug 27, 2012 |
| Last update date |
Mar 25, 2019 |
| Contact name |
Claire Q.F. Wang |
| E-mail(s) |
[email protected]
|
| Phone |
+1-212-327-7153
|
| Fax |
+1-212-327-8232
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| Organization name |
Rockefeller University
|
| Lab |
Laboratory for Investigative Dermatology
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| Street address |
1230 York Ave
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| City |
New York |
| State/province |
NY |
| ZIP/Postal code |
10065 |
| Country |
USA |
| |
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| Platforms (1) |
| GPL570 |
[HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array |
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| Samples (12)
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| Relations |
| BioProject |
PRJNA173896 |
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