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Status |
Public on Aug 31, 2006 |
Title |
Gefitinib sensitivity in NSCLC cell lines |
Organism |
Homo sapiens |
Experiment type |
Expression profiling by array
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Summary |
Eleven NSCLC cell lines with widely divergent gefitinib sensitivities were compared using gene expression. Genes associated with gefitinib response were used to classify additional NSCLC lines with unknown gefitnib sensitivity. A subset of the test set data was tested for gefitinib sensitivity, and results correlated strongly with the gene expression-based predictions
All eleven training set lines, and seven test set lines had both HGU133A and B chips done, while other test set lines had only HGU133As. Keywords: cell response comparison
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Overall design |
Baseline (unstimulated) gene expression was measured in a large panel of NSCLC cell lines
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Contributor(s) |
Coldren CD, Helfrich BA, Witta SE, Sugita M, Lapadat R, Zeng C, Barón A, Franklin WA, Hirsch FR, Minna JD, Geraci MW, Bunn PA Jr |
Citation(s) |
16877703, 19634903 |
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Submission date |
Mar 06, 2006 |
Last update date |
Aug 20, 2019 |
Contact name |
Christopher D Coldren |
E-mail(s) |
[email protected]
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Phone |
303 724 6056
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Organization name |
University of Colorado School of Medicine
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Department |
Medicine
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Lab |
Pulmonary Sciences and Critical Care Medicine
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Street address |
12700 East 17th Place
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City |
Aurora |
State/province |
CO |
ZIP/Postal code |
80045 |
Country |
USA |
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Platforms (2) |
GPL96 |
[HG-U133A] Affymetrix Human Genome U133A Array |
GPL97 |
[HG-U133B] Affymetrix Human Genome U133B Array |
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Samples (63)
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Relations |
BioProject |
PRJNA94835 |