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| Status |
Public on Mar 13, 2014 |
| Title |
Expression data from Neuro2a mouse neuroblastoma cell lines, anchorage dependent cells (AD) and anchorage-independent tumorspheres (AI) |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
The ability of high-risk neuroblastoma to survive unfavorable growth conditions and multimodal therapy is hypothesized to result from a phenomenon known as reversible adaptive plasticity (RAP). RAP is a novel phenomenon enabling neuroblastoma cells to transition between a proliferative anchorage dependent (AD) state and a slow growing anoikis-resistant anchorage independent (AI) state.
We used microarrays to investigate the global gene expression profiles in AD and AI cells, and to identify the differential expressed genes within signaling pathways contributing to the reversible adaptive plasticity between AD and AI cells.
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| Overall design |
Comparison of microarray data from AD cells (n=4 independent cultures) versus AI cells (n=4 independent cultures) were performed using Partek Genomics Suite 6.5. Differentially expressed genes with an FDR ≤5% and a fold-change ≥1.5 were selected for pathway analysis.
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| Contributor(s) |
Wang B, Chakrabarti L, Sandler AD, Lee NH |
| Citation(s) |
24376712 |
| |
| Submission date |
Mar 14, 2013 |
| Last update date |
Mar 04, 2019 |
| Contact name |
Bi-Dar Wang |
| E-mail(s) |
[email protected]
|
| Phone |
202-994-3543
|
| Fax |
202-994-2870
|
| Organization name |
The George Washington University Medical Center
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| Department |
Pharmacology and Physiology
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| Street address |
2300 I street, NW
|
| City |
Washington |
| State/province |
DC |
| ZIP/Postal code |
20037 |
| Country |
USA |
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| Platforms (1) |
| GPL6246 |
[MoGene-1_0-st] Affymetrix Mouse Gene 1.0 ST Array [transcript (gene) version] |
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| Samples (8)
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| Relations |
| BioProject |
PRJNA193084 |
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