|
| Status |
Public on Mar 30, 2014 |
| Title |
Expression Data from murine control and IL6ralpha-deficient macrophages stimulated with Interleukin-6 |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
|
| Summary |
IL-6 induces IL4ralpha expression in macrophages. This mechanism is necessary to promote macrophage polarization towards an M2-phenotype and is crucial to limit the inflammatory response both upon obesity and LPS-endotoxemia.
In this dataset, we include the expression data obtained from primary murine bone marrow-derived macrophages from control and IL6ralpha-deficient macrophages (n=4vs4) stimulated with interleukin-6 (IL-6)
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| |
|
| Overall design |
8 samples were analyzed to compare control and IL6ralpha-deficient macrophages for their gene expression profiles upon stimulation with IL-6
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| |
|
| Contributor(s) |
Mauer J, Brüning JC |
| Citation(s) |
24681566 |
| |
| Submission date |
May 28, 2013 |
| Last update date |
Mar 04, 2019 |
| Contact name |
Jan Mauer |
| E-mail(s) |
[email protected]
|
| Organization name |
BioMed X Innovation Center
|
| Street address |
Im Neuenheimer Feld, 583
|
| City |
Heidelberg |
| State/province |
BW |
| ZIP/Postal code |
69120 |
| Country |
Germany |
| |
|
| Platforms (1) |
| GPL6246 |
[MoGene-1_0-st] Affymetrix Mouse Gene 1.0 ST Array [transcript (gene) version] |
|
| Samples (8)
|
| GSM1149302 |
Ctrl macrophages biological replicate 1 |
| GSM1149303 |
Ctrl macrophages biological replicate 2 |
| GSM1149304 |
Ctrl macrophages biological replicate 3 |
| GSM1149305 |
Ctrl macrophages biological replicate 4 |
| GSM1149306 |
IL6raKO macrophages biological replicate 1 |
| GSM1149307 |
IL6raKO macrophages biological replicate 2 |
| GSM1149308 |
IL6raKO macrophages biological replicate 3 |
| GSM1149309 |
IL6raKO macrophages biological replicate 4 |
|
| Relations |
| BioProject |
PRJNA205543 |
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