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Series GSE48352 Query DataSets for GSE48352
Status Public on Jun 01, 2016
Title DPYS as a potential diagnostic biomarker in hereditary and sporadic PRCC2
Organism Homo sapiens
Experiment type Expression profiling by array
Summary Papillary renal cell carcinoma type 2 (PRCC2) is known to be very aggressive type of tumor without effictive therapy. Hereditary form of PRCC2 is caused by Fumarate Hydratase (FH) gene mutation that accompanied Hereditary Leiomyomatosis and Renal Cell Carcinoma (HLRCC) disorder. In sporadic form of PRCC2 the mutation of FH gene has not been reported. Both forms of tumors have the similar histopathological characteristics with poor survival prognosis.
In this study, we profiled the gene expression of renal tumors and normal tissue from PRCC2 (hereditary and sporadic) patients in order to better understand commonalities and differences in the transcriptional landscape of PRCC2.
 
Overall design Microarray gene expression profiling was performed on eight normal kidney tissue samples, five hereditary PRCC2 tumor tissue samples and 19 sporadic PRCC2 tumor tissue samples. Hereditary PRCC2 (HPRCC2) patients were confirmed by DNA sequencing of the FH gene.
 
Contributor(s) PERRIER-TRUDOVA V, OOI A, LIM WK, PETILLO D
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Submission date Jun 27, 2013
Last update date Jun 02, 2016
Contact name Weng Khong Lim
E-mail(s) [email protected]
Organization name National Cancer Centre Singapore
Department Department of Medical Sciences
Lab NCCS-VARI Translational Research Laboratory
Street address 11 Hospital Drive
City Singapore
State/province Singapore
ZIP/Postal code 169610
Country Singapore
 
Platforms (1)
GPL16311 [HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array [CDF: Brainarray HGU133Plus2_Hs_ENTREZG 14.0.0]
Samples (32)
GSM1176286 HereditaryPRCC2_NormalTissue_1
GSM1176287 HereditaryPRCC2_NormalTissue_2
GSM1176288 SporadicPRCC2_NormalTissue_1
Relations
BioProject PRJNA209811

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE48352_RAW.tar 172.9 Mb (http)(custom) TAR (of CEL)
Processed data included within Sample table

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