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Series GSE59 Query DataSets for GSE59
Status Public on Jun 27, 2002
Title Human cancer cell lines
Organism Homo sapiens
Experiment type Expression profiling by array
Summary We used cDNA microarrays to explore the variation in expression of approximately 8,000 unique genes among the 60 cell lines used in the National Cancer Institute's screen for anti-cancer drugs. Classification of the cell lines based solely on the observed patterns of gene expression revealed a correspondence to the ostensible origins of the tumors from which the cell lines were derived. The consistent relationship between the gene expression patterns and the tissue of origin allowed us to recognize outliers whose previous classification appeared incorrect. Specific features of the gene expression patterns appeared to be related to physiological properties of the cell lines, such as their doubling time in culture, drug metabolism or the interferon response. Comparison of gene expression patterns in the cell lines to those observed in normal breast tissue or in breast tumor specimens revealed features of the expression patterns in the tumors that had recognizable counterparts in specific cell lines, reflecting the tumor, stromal and inflammatory components of the tumor tissue. These results provided a novel molecular characterization of this important group of human cell lines and their relationships to tumors in vivo.
This study is described more fully in Ross DT et al.(2000) Nat Genet 24:227-35
Keywords: other
 
 
Contributor(s) Ross DT, Scherf U, Eisen U, Perou CM, Rees C, Spellman P, Iyer V, Jeffrey SS, van de Rijn M, Waltham M, Pergamenschikov A, Lee JC, Lashkari D, Shalon D, Myers TG, Weinstein JN, Botstein D, Brown PO
Citation(s) 10700174
Submission date Jun 24, 2002
Last update date Feb 23, 2012
Organization Stanford Microarray Database (SMD)
E-mail(s) [email protected]
Phone 650-498-6012
URL http://genome-www5.stanford.edu/
Department Stanford University, School of Medicine
Street address 300 Pasteur Drive
City Stanford
State/province CA
ZIP/Postal code 94305
Country USA
 
Platforms (2)
GPL167 10k_Print3
GPL169 10k_print2
Samples (68)
GSM2089 COLO205_CL4010_COLON
GSM2090 SNB-19_CL12002_CNS
GSM2091 UACC-62_CL10020_MELANOMA
Relations
BioProject PRJNA85373

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