|
| Status |
Public on Dec 18, 2007 |
| Title |
The global transcriptional profile of Mycobacterium tuberculosis during human macrophages infection |
| Organism |
Mycobacterium tuberculosis |
| Experiment type |
Expression profiling by array
|
| Summary |
During lung infection Mycobacterium tuberculosis (Mtb) resides in macrophages and subverts the bactericidal mechanisms of these professional phagocytes.
In this work we have analyzed by DNA microarray technique the global transcription profile of Mtb infecting primary human macrophages in order to identify putative bacterial pathogenic factors that can be relevant for the intracellular survival of Mtb.
Keywords: time course
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|
| Overall design |
We compared the global gene expression of the H37Rv strain of Mtb after 4 hours and 24 hours of infection of human macrophage-like THP-1 cells with the gene expression profile of the strain growing exponentially in broth cultures.
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| |
|
| Contributor(s) |
Fontan P, Aris VM, Ghanny SS, Soteropoulos P, Smith I |
| Citation(s) |
18657035, 18070897 |
| |
| Submission date |
Nov 01, 2006 |
| Last update date |
Sep 26, 2019 |
| Contact name |
Virginie Marie Aris |
| E-mail(s) |
[email protected]
|
| Phone |
973-854-3455
|
| Fax |
973-854-3453
|
| URL |
http://www.cag.icph.org/
|
| Organization name |
PHRI-UMNDJ
|
| Department |
Center For Applied Genomics
|
| Lab |
Soteropoulos
|
| Street address |
W420M, 225 Warren St
|
| City |
Newark |
| State/province |
NJ |
| ZIP/Postal code |
07103 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL4057 |
PHRI-UMNDJ Mycobacterium tuberculosis 4.8K CAG_Mtb |
|
| Samples (11)
|
| GSM143399 |
H37Rv 4hrs after infection in macrophage vs. H37Rv grown in 7H9 media biological replicate 1 (A 4hrs) |
| GSM143400 |
H37Rv 4hrs after infection in macrophage vs. H37Rv grown in 7H9 media biological replicate 2 (B 4hrs) |
| GSM143401 |
H37Rv 4hrs after infection in macrophage vs. H37Rv grown in 7H9 media biological replicate 3 (C 4hrs) |
| GSM143402 |
H37Rv 4hrs after infection in macrophage vs. H37Rv grown in 7H9 media biological replicate 4 (D 4hrs) |
| GSM143403 |
H37Rv 4hrs after infection in macrophage vs. H37Rv grown in 7H9 media biological replicate 5 (E 4hrs) |
| GSM143404 |
H37Rv 24hrs after infection in macrophage vs. H37Rv grown in 7H9 media biological replicate 1 (A 24hrs) |
| GSM143405 |
H37Rv 24hrs after infection in macrophage vs. H37Rv grown in 7H9 media biological replicate 2 (B 24hrs) |
| GSM143406 |
H37Rv 24hrs after infection in macrophage vs. H37Rv grown in 7H9 media biological replicate 3 (C 24hrs) |
| GSM143407 |
H37Rv 24hrs after infection in macrophage vs. H37Rv grown in 7H9 media biological replicate 4 (D 24hrs) |
| GSM143408 |
H37Rv 24hrs after infection in macrophage vs. H37Rv grown in 7H9 media biological replicate 5 (E 24hrs) |
| GSM206719 |
H37Rv 4hrs after infection in macrophage vs. H37Rv grown in 7H9 media biological replicate 6 (A 4hrs) |
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| This SubSeries is part of SuperSeries: |
| GSE7963 |
Mycobacterium tuberculosis and macrophage response |
|
| Relations |
| BioProject |
PRJNA104989 |
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