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Series GSE63027 Query DataSets for GSE63027
Status Public on Nov 07, 2014
Title Expression data from GNMT and MAT1A knockout models that develop all the stages of non-alcoholic fatty liver disease including hepatocellular carcinoma [GNMT_MAT1A_3&8_months]
Organism Mus musculus
Experiment type Expression profiling by array
Summary Liver global gene expression patterns of 9 GNMT-knockout mice histopathologically determined to have non-alcoholic steatohepatitis (NASH) and hepatocellular carcinoma (HCC) together with 10 MAT1A-knockout mice histopathologically determined to have steatosis and NASH. All these have their respective wild type patterns. These were analyzed to define signatures to study the pathogenesis of NAFLD-derived HCC, explore which subtypes of cancers can be investigated using mouse models and define a signature of HCC differential survival that can be used to characterize HCC subtypes of different survival derived from mixed etiologies.
 
Overall design GNMT- and MAT1A-knockout mice liver samples having steatosis, non-alcoholic steatohepatitis and hepatocellular carcinoma were selected for RNA extraction and hybridization on Affymetrix microarrays.
 
Contributor(s) Frades I
Citation(s) 25993042
Submission date Nov 05, 2014
Last update date Feb 11, 2019
Contact name Itziar Frades
Organization name Swedish University of Agricultural Sciences
Department Plant Protection Biology
Street address Sundsvägen 14
City Alnarp
ZIP/Postal code SE-230 53
Country Sweden
 
Platforms (1)
GPL1261 [Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array
Samples (39)
GSM1538257 Wild type used for GNMT 3 month, replicate 1
GSM1538258 Wild type used for GNMT 3 month, replicate 2
GSM1538259 Wild type used for GNMT 3 month, replicate 3
This SubSeries is part of SuperSeries:
GSE63068 Integrative genomic signatures of hepatocellular carcinoma derived from nonalcoholic fatty liver disease
Relations
BioProject PRJNA266542

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE63027_KO_vs_WT_ratios.txt.gz 7.1 Mb (ftp)(http) TXT
GSE63027_RAW.tar 134.0 Mb (http)(custom) TAR (of CEL)
Processed data included within Sample table
Processed data are available on Series record

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