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| Status |
Public on Jun 21, 2007 |
| Title |
Genome-wide molecular profiles of HCV-induced dysplasia and hepatocellular carcinoma |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
Gene expression profiles of 75 tissue samples were analyzed representing the stepwise carcinogenic process from pre-neoplastic lesions (cirrhosis and dysplasia) to HCC, including four neoplastic stages (very early HCC to metastatic tumors) from patients with HCV infection. Gene signatures that accurately reflect the pathological progression of disease at each stage were identified and potential molecular markers for early diagnosis uncovered. Pathway analysis revealed dysregulation of the Notch and Toll-like receptor pathways in cirrhosis, followed by deregulation of several components of the Jak/STAT pathway in early carcinogenesis, then up-regulation of genes involved in DNA replication and repair and cell cycle in late cancerous stages.
Keywords: 8 pathological stages of HCV-induced HCC
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| Overall design |
75 samples covering 8 stages of HCV induced HCC, with up to 13 biological repeats for each stage. Normal liver were used as control.
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| Contributor(s) |
Wurmbach E, Chen Y, Khitrov G, Zhang W, Roayaie S, Schwartz M, Fiel I, Thung S, Mazzaferro V, Bruix J, Bottinger E, Friedman S, Waxman S, Llovet JM |
| Citation(s) |
17393520 |
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| Submission date |
Jan 17, 2007 |
| Last update date |
Mar 25, 2019 |
| Contact name |
Elisa Wurmbach |
| E-mail(s) |
[email protected]
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| Phone |
212-241-9779
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| Organization name |
Mount Sinai School of Medicine
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| Department |
Hematology/Oncology
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| Lab |
Sam Waxman
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| Street address |
1 Gustave L. Levy Place
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| City |
New York |
| State/province |
NY |
| ZIP/Postal code |
10029 |
| Country |
USA |
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| Platforms (1) |
| GPL570 |
[HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array |
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| Samples (75)
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| Relations |
| BioProject |
PRJNA98935 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE6764_RAW.tar |
588.7 Mb |
(http)(custom) |
TAR (of CEL) |
| Processed data included within Sample table |
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