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Series GSE8397 Query DataSets for GSE8397
Status Public on Jan 01, 2008
Title Expression profiling of the Parkinsonian Brain
Organism Homo sapiens
Experiment type Expression profiling by array
Summary Affymetrix HG_U133 array sets (A and B chips) were used to determine the whole genome transcription profile of clinically documented and neuropathologically confirmed cases of sporadic Parkinson's disease as well as controls.
Keywords: disease-state analysis
 
Overall design Post mortem brain tissue samples from Parkinson's disease and control cases (substantia nigra, split into medial and lateral portions, and frontal cortex) were prepared for this study. In total, 47 individual tissue samples were analyzed using one A and one B GeneChip per sample, i.e. 15 samples of medial parkinsonian SN, 9 samples of lateral parkinsonian SN, 8 medial nigra control samples and 7 lateral nigra control samples. Lateral and medial nigra samples were from the same cases. In addition, frontal cerebral cortex was analyzed in five of the PD cases and in three of the controls (Neurogenetics 2006 7: 1–11; Acta Neuropathologica (Berlin) 2007 113: 253-263
Web link http://www.neurogenetics.net/Parkinson.htm
 
Contributor(s) Moran LB, Graeber MB
Citation(s) 16344956, 17211632
Submission date Jul 06, 2007
Last update date Aug 10, 2018
Contact name Linda B Moran
Organization name Imperial College London
Department Neuropathology
Street address Fulham Palace Road
City London
ZIP/Postal code W6 8RF
Country United Kingdom
 
Platforms (2)
GPL96 [HG-U133A] Affymetrix Human Genome U133A Array
GPL97 [HG-U133B] Affymetrix Human Genome U133B Array
Samples (94)
GSM208622 Superior frontal gyrus control case 2 - A chip
GSM208623 Superior frontal gyrus control case 3 - A chip
GSM208624 Superior frontal gyrus control case 9 - A chip
Relations
BioProject PRJNA101445

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Supplementary file Size Download File type/resource
GSE8397_RAW.tar 303.3 Mb (http)(custom) TAR (of CEL)
Processed data included within Sample table
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