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| Status |
Public on Dec 01, 2017 |
| Title |
Intergenerational transfer of antibiotic-perturbed microbiota enhances colitis in susceptible mice. |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
Antibiotics have long-lasting consequences on the gut microbiota with the potential to impact host physiology and health. However, little is known about the transgenerational impact of an antibiotic-perturbed microbiota. Here we demonstrated that adult pregnant female mice inoculated with a gut microbial community shaped by antibiotic exposure passed on their dysbiotic microbiota to their offspring. This dysbiotic microbiota remained distinct from controls for at least 5 months in the offspring without any continued exposure to antibiotics. By using IL-10 deficient mice, which are genetically susceptible to colitis, we showed mice that received an antibiotic-perturbed gut microbiota from their mothers had increased risk of colitis. Taken together, our findings indicate that the consequences of antibiotic exposure affecting the gut microbiota can extend to a second generation.
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| Overall design |
C57BL/6 or IL10 deficient pups were born to mothers who were exposed to Control or STAT-perturbed cecal contents. (N = 3/group)
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| Contributor(s) |
Schulfer AF, Battaglia T, Alvarez Y, Ruiz VE, Ho M, Robinson S, Ward T, Cox LM, Rogers AB, Knights D, Sartor B, Blaser MJ |
| Citation(s) |
29180726 |
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| Submission date |
Dec 20, 2016 |
| Last update date |
Jul 09, 2019 |
| Contact name |
Thomas W Battaglia |
| Organization name |
NYU School of Medicine
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| Department |
Medicine
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| Lab |
Blaser Lab
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| Street address |
423 E 23rd Street
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| City |
New York |
| State/province |
NY |
| ZIP/Postal code |
10010 |
| Country |
USA |
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| Platforms (1) |
| GPL19964 |
nCounter Mouse Immunology Panel |
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| Samples (12)
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| Relations |
| BioProject |
PRJNA358195 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE92623_RAW.tar |
90.0 Kb |
(http)(custom) |
TAR (of RCC) |
| Processed data included within Sample table |
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