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Malignant glioma

MedGen UID:
107826
•Concept ID:
C0555198
•
Neoplastic Process
Synonyms: Glioma, Malignant; Gliomas, Malignant; Malignant Glioma; Malignant Gliomas
SNOMED CT: Glioma, malignant (74532006); Malignant glioma (74532006)
 
Monarch Initiative: MONDO:0100342

Definition

A grade 3 or grade 4 glioma arising from the central nervous system. This category includes glioblastoma, anaplastic astrocytoma, anaplastic ependymoma, anaplastic oligodendroglioma, and anaplastic oligoastrocytoma. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • Malignant glioma

Professional guidelines

PubMed

Tumor Treating Fields in the Management of Patients with Malignant Gliomas.
Ghiaseddin AP, Shin D, Melnick K, Tran DD
Curr Treat Options Oncol 2020 Jul 30;21(9):76. doi: 10.1007/s11864-020-00773-5. PMID: 32734509Free PMC Article
ESTRO-ACROP guideline "target delineation of glioblastomas".
Niyazi M, Brada M, Chalmers AJ, Combs SE, Erridge SC, Fiorentino A, Grosu AL, Lagerwaard FJ, Minniti G, Mirimanoff RO, Ricardi U, Short SC, Weber DC, Belka C
Radiother Oncol 2016 Jan;118(1):35-42. Epub 2016 Jan 6 doi: 10.1016/j.radonc.2015.12.003. PMID: 26777122
Evolution of malignant glioma treatment: from chemotherapy to vaccines to viruses.
Price RL, Chiocca EA
Neurosurgery 2014 Aug;61 Suppl 1(0 1):74-83. doi: 10.1227/NEU.0000000000000390. PMID: 25032534Free PMC Article

Recent clinical studies

Etiology

Practical guidance for direct oral anticoagulant use in the treatment of venous thromboembolism in primary and metastatic brain tumor patients.
Ranjan S, Leung D, Ghiaseddin AP, Taylor JW, Lobbous M, Dhawan A, Budhu JA, Coffee E, Melnick K, Chowdhary SA, Lu-Emerson C, Kurz SC, Burke JE, Lam K, Patel MP, Dunbar EM, Mohile NA, Peters KB
Cancer 2024 May 1;130(9):1577-1589. Epub 2024 Jan 30 doi: 10.1002/cncr.35220. PMID: 38288941
Origin of Gliomas.
Cahill D, Turcan S
Semin Neurol 2018 Feb;38(1):5-10. Epub 2018 Mar 16 doi: 10.1055/s-0037-1620238. PMID: 29548046
Glioblastoma and other malignant gliomas: a clinical review.
Omuro A, DeAngelis LM
JAMA 2013 Nov 6;310(17):1842-50. doi: 10.1001/jama.2013.280319. PMID: 24193082
Paediatric and adult malignant glioma: close relatives or distant cousins?
Jones C, Perryman L, Hargrave D
Nat Rev Clin Oncol 2012 May 29;9(7):400-13. doi: 10.1038/nrclinonc.2012.87. PMID: 22641364
Malignant glioma: ESMO clinical recommendations for diagnosis, treatment and follow-up.
Stupp R, Roila F; ESMO Guidelines Working Group
Ann Oncol 2009 May;20 Suppl 4:126-8. doi: 10.1093/annonc/mdp151. PMID: 19454432

Diagnosis

Malignant Glioma.
Wang LM, Englander ZK, Miller ML, Bruce JN
Adv Exp Med Biol 2023;1405:1-30. doi: 10.1007/978-3-031-23705-8_1. PMID: 37452933
The epigenetic dysfunction underlying malignant glioma pathogenesis.
Dharmaiah S, Huse JT
Lab Invest 2022 Jul;102(7):682-690. Epub 2022 Feb 12 doi: 10.1038/s41374-022-00741-7. PMID: 35152274
Immunotherapy and Response Assessment in Malignant Glioma: Neuro-oncology Perspective.
Bagley SJ, Desai AS, Nasrallah MP, O'Rourke DM
Top Magn Reson Imaging 2020 Apr;29(2):95-102. doi: 10.1097/RMR.0000000000000233. PMID: 32271286
Anaplastic astrocytoma.
Grimm SA, Chamberlain MC
CNS Oncol 2016 Jul;5(3):145-57. Epub 2016 May 27 doi: 10.2217/cns-2016-0002. PMID: 27230974Free PMC Article
Glioblastoma and other malignant gliomas: a clinical review.
Omuro A, DeAngelis LM
JAMA 2013 Nov 6;310(17):1842-50. doi: 10.1001/jama.2013.280319. PMID: 24193082

Therapy

Tumor Treating Fields in the Management of Patients with Malignant Gliomas.
Ghiaseddin AP, Shin D, Melnick K, Tran DD
Curr Treat Options Oncol 2020 Jul 30;21(9):76. doi: 10.1007/s11864-020-00773-5. PMID: 32734509Free PMC Article
Challenges to Successful Implementation of the Immune Checkpoint Inhibitors for Treatment of Glioblastoma.
Sanders S, Debinski W
Int J Mol Sci 2020 Apr 16;21(8) doi: 10.3390/ijms21082759. PMID: 32316096Free PMC Article
Anaplastic astrocytoma.
Grimm SA, Chamberlain MC
CNS Oncol 2016 Jul;5(3):145-57. Epub 2016 May 27 doi: 10.2217/cns-2016-0002. PMID: 27230974Free PMC Article
Bevacizumab and glioblastoma: scientific review, newly reported updates, and ongoing controversies.
Field KM, Jordan JT, Wen PY, Rosenthal MA, Reardon DA
Cancer 2015 Apr 1;121(7):997-1007. Epub 2014 Sep 26 doi: 10.1002/cncr.28935. PMID: 25263092
Oncolytic viral therapy of malignant glioma.
Parker JN, Bauer DF, Cody JJ, Markert JM
Neurotherapeutics 2009 Jul;6(3):558-69. doi: 10.1016/j.nurt.2009.04.011. PMID: 19560745Free PMC Article

Prognosis

Malignant Glioma.
Wang LM, Englander ZK, Miller ML, Bruce JN
Adv Exp Med Biol 2023;1405:1-30. doi: 10.1007/978-3-031-23705-8_1. PMID: 37452933
Recurrent Glioblastoma Treated with Recombinant Poliovirus.
Desjardins A, Gromeier M, Herndon JE 2nd, Beaubier N, Bolognesi DP, Friedman AH, Friedman HS, McSherry F, Muscat AM, Nair S, Peters KB, Randazzo D, Sampson JH, Vlahovic G, Harrison WT, McLendon RE, Ashley D, Bigner DD
N Engl J Med 2018 Jul 12;379(2):150-161. Epub 2018 Jun 26 doi: 10.1056/NEJMoa1716435. PMID: 29943666Free PMC Article
Phase I Study of DNX-2401 (Delta-24-RGD) Oncolytic Adenovirus: Replication and Immunotherapeutic Effects in Recurrent Malignant Glioma.
Lang FF, Conrad C, Gomez-Manzano C, Yung WKA, Sawaya R, Weinberg JS, Prabhu SS, Rao G, Fuller GN, Aldape KD, Gumin J, Vence LM, Wistuba I, Rodriguez-Canales J, Villalobos PA, Dirven CMF, Tejada S, Valle RD, Alonso MM, Ewald B, Peterkin JJ, Tufaro F, Fueyo J
J Clin Oncol 2018 May 10;36(14):1419-1427. Epub 2018 Feb 12 doi: 10.1200/JCO.2017.75.8219. PMID: 29432077Free PMC Article
Management of recurrent malignant glioma--neurosurgical strategies.
Kostron H, Bauer R
Wien Med Wochenschr 2011 Jan;161(1-2):20-1. doi: 10.1007/s10354-010-0861-7. PMID: 21312095
Malignant glioma: ESMO clinical recommendations for diagnosis, treatment and follow-up.
Stupp R, Roila F; ESMO Guidelines Working Group
Ann Oncol 2009 May;20 Suppl 4:126-8. doi: 10.1093/annonc/mdp151. PMID: 19454432

Clinical prediction guides

The Evolving Role of CD8(+)CD28(-) Immunosenescent T Cells in Cancer Immunology.
Huff WX, Kwon JH, Henriquez M, Fetcko K, Dey M
Int J Mol Sci 2019 Jun 8;20(11) doi: 10.3390/ijms20112810. PMID: 31181772Free PMC Article
Recurrent Glioblastoma Treated with Recombinant Poliovirus.
Desjardins A, Gromeier M, Herndon JE 2nd, Beaubier N, Bolognesi DP, Friedman AH, Friedman HS, McSherry F, Muscat AM, Nair S, Peters KB, Randazzo D, Sampson JH, Vlahovic G, Harrison WT, McLendon RE, Ashley D, Bigner DD
N Engl J Med 2018 Jul 12;379(2):150-161. Epub 2018 Jun 26 doi: 10.1056/NEJMoa1716435. PMID: 29943666Free PMC Article
The Neurologic Assessment in Neuro-Oncology (NANO) scale: a tool to assess neurologic function for integration into the Response Assessment in Neuro-Oncology (RANO) criteria.
Nayak L, DeAngelis LM, Brandes AA, Peereboom DM, Galanis E, Lin NU, Soffietti R, Macdonald DR, Chamberlain M, Perry J, Jaeckle K, Mehta M, Stupp R, Muzikansky A, Pentsova E, Cloughesy T, Iwamoto FM, Tonn JC, Vogelbaum MA, Wen PY, van den Bent MJ, Reardon DA
Neuro Oncol 2017 May 1;19(5):625-635. doi: 10.1093/neuonc/nox029. PMID: 28453751Free PMC Article
Mechanisms of proteasome inhibitor-induced cytotoxicity in malignant glioma.
Vlachostergios PJ, Voutsadakis IA, Papandreou CN
Cell Biol Toxicol 2013 Aug;29(4):199-211. Epub 2013 Jun 5 doi: 10.1007/s10565-013-9248-z. PMID: 23733249
Immunostimulatory oligonucleotides.
Bodera P
Recent Pat Inflamm Allergy Drug Discov 2011 Jan;5(1):87-93. doi: 10.2174/187221311794474856. PMID: 21158735

Recent systematic reviews

Telomerase inhibition in malignant gliomas: a systematic review.
D'Alessandris QG, Battistelli M, Pennisi G, Offi M, Martini M, Cenci T, Falchetti ML, Lauretti L, Olivi A, Pallini R, Montano N
Expert Rev Mol Med 2023 Mar 15;25:e10. doi: 10.1017/erm.2023.6. PMID: 36919343
Role of ketogenic metabolic therapy in malignant glioma: A systematic review.
Winter SF, Loebel F, Dietrich J
Crit Rev Oncol Hematol 2017 Apr;112:41-58. Epub 2017 Feb 20 doi: 10.1016/j.critrevonc.2017.02.016. PMID: 28325264
Chemotherapy for Adults with Malignant Glioma: A Systematic Review and Network Meta-Analysis.
Wang W, Shi G, Ma B, Hao X, Dong X, Zhang B
Turk Neurosurg 2017;27(2):174-181. doi: 10.5137/1019-5149.JTN.15462-15.0. PMID: 27337236
Dendritic cell-based vaccine for the treatment of malignant glioma: a systematic review.
Wang X, Zhao HY, Zhang FC, Sun Y, Xiong ZY, Jiang XB
Cancer Invest 2014 Nov;32(9):451-7. Epub 2014 Sep 26 doi: 10.3109/07357907.2014.958234. PMID: 25259676
The effectiveness and cost-effectiveness of temozolomide for the treatment of recurrent malignant glioma: a rapid and systematic review.
Dinnes J, Cave C, Huang S, Major K, Milne R
Health Technol Assess 2001;5(13):1-73. doi: 10.3310/hta5130. PMID: 11359682

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