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Seminoma

MedGen UID:
11371
•Concept ID:
C0036631
•
Neoplastic Process
Synonym: Seminomas
SNOMED CT: Seminoma (443675005); Malignant seminoma (1162765005)
 
Monarch Initiative: MONDO:0003001
OMIM®: 273300

Definition

A radiosensitive malignant germ cell tumor found in the testis (especially undescended), and extragonadal sites (anterior mediastinum and pineal gland). It is characterized by the presence of uniform cells with clear or dense cytoplasm which contains glycogen, and by a large nucleus which contains one or more nucleoli. The neoplastic germ cells form aggregates separated by fibrous septa. The fibrous septa contain chronic inflammatory cells, mainly lymphocytes. [from NCI]

Professional guidelines

PubMed

Testicular seminoma and non-seminoma: ESMO-EURACAN Clinical Practice Guideline for diagnosis, treatment and follow-up.
Oldenburg J, Berney DM, Bokemeyer C, Climent MA, Daugaard G, Gietema JA, De Giorgi U, Haugnes HS, Huddart RA, Leão R, Sohaib A, Gillessen S, Powles T; ESMO Guidelines Committee. Electronic address: [email protected]; EURACAN
Ann Oncol 2022 Apr;33(4):362-375. Epub 2022 Jan 19 doi: 10.1016/j.annonc.2022.01.002. PMID: 35065204
Testicular Cancer, Version 2.2020, NCCN Clinical Practice Guidelines in Oncology.
Gilligan T, Lin DW, Aggarwal R, Chism D, Cost N, Derweesh IH, Emamekhoo H, Feldman DR, Geynisman DM, Hancock SL, LaGrange C, Levine EG, Longo T, Lowrance W, McGregor B, Monk P, Picus J, Pierorazio P, Rais-Bahrami S, Saylor P, Sircar K, Smith DC, Tzou K, Vaena D, Vaughn D, Yamoah K, Yamzon J, Johnson-Chilla A, Keller J, Pluchino LA
J Natl Compr Canc Netw 2019 Dec;17(12):1529-1554. doi: 10.6004/jnccn.2019.0058. PMID: 31805523
Testicular Cancer: Epidemiology, Diagnosis, and Management.
Smith ZL, Werntz RP, Eggener SE
Med Clin North Am 2018 Mar;102(2):251-264. Epub 2017 Dec 21 doi: 10.1016/j.mcna.2017.10.003. PMID: 29406056

Curated

NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®), Testicular Cancer, 2024

Recent clinical studies

Etiology

Testicular seminoma and non-seminoma: ESMO-EURACAN Clinical Practice Guideline for diagnosis, treatment and follow-up.
Oldenburg J, Berney DM, Bokemeyer C, Climent MA, Daugaard G, Gietema JA, De Giorgi U, Haugnes HS, Huddart RA, Leão R, Sohaib A, Gillessen S, Powles T; ESMO Guidelines Committee. Electronic address: [email protected]; EURACAN
Ann Oncol 2022 Apr;33(4):362-375. Epub 2022 Jan 19 doi: 10.1016/j.annonc.2022.01.002. PMID: 35065204
New treatments for stage I testicular cancer.
Nappi L, Nichols CR, Kollmannsberger CK
Clin Adv Hematol Oncol 2017 Aug;15(8):626-631. PMID: 28949950
Testicular Seminoma and Its Mimics: From the Radiologic Pathology Archives.
Marko J, Wolfman DJ, Aubin AL, Sesterhenn IA
Radiographics 2017 Jul-Aug;37(4):1085-1098. Epub 2017 Jun 2 doi: 10.1148/rg.2017160164. PMID: 28574809Free PMC Article
Management of Low-Stage Testicular Seminoma.
Pearce SM, Liauw SL, Eggener SE
Urol Clin North Am 2015 Aug;42(3):287-98. Epub 2015 Jun 6 doi: 10.1016/j.ucl.2015.04.003. PMID: 26216816
Testicular cancer.
MacVicar GR, Pienta KJ
Curr Opin Oncol 2004 May;16(3):253-6. doi: 10.1097/00001622-200405000-00011. PMID: 15069322

Diagnosis

Testicular seminoma and non-seminoma: ESMO-EURACAN Clinical Practice Guideline for diagnosis, treatment and follow-up.
Oldenburg J, Berney DM, Bokemeyer C, Climent MA, Daugaard G, Gietema JA, De Giorgi U, Haugnes HS, Huddart RA, Leão R, Sohaib A, Gillessen S, Powles T; ESMO Guidelines Committee. Electronic address: [email protected]; EURACAN
Ann Oncol 2022 Apr;33(4):362-375. Epub 2022 Jan 19 doi: 10.1016/j.annonc.2022.01.002. PMID: 35065204
Indications for Surgery in Disseminated Seminoma.
Pierorazio PM, Biles MJ
Urol Clin North Am 2019 Aug;46(3):399-407. Epub 2019 May 21 doi: 10.1016/j.ucl.2019.04.005. PMID: 31277734
Pure seminoma: a review and update.
Boujelbene N, Cosinschi A, Boujelbene N, Khanfir K, Bhagwati S, Herrmann E, Mirimanoff RO, Ozsahin M, Zouhair A
Radiat Oncol 2011 Aug 8;6:90. doi: 10.1186/1748-717X-6-90. PMID: 21819630Free PMC Article
Spermatocytic seminoma.
Aggarwal N, Parwani AV
Arch Pathol Lab Med 2009 Dec;133(12):1985-8. doi: 10.5858/133.12.1985. PMID: 19961257
Testicular cancer.
Brock D, Fox S, Gosling G, Haney L, Kneebone P, Nagy C, Qualitza B
Semin Oncol Nurs 1993 Nov;9(4):224-36. doi: 10.1016/s0749-2081(05)80051-8. PMID: 8290818

Therapy

Surgery in Early Metastatic Seminoma: A Phase II Trial of Retroperitoneal Lymph Node Dissection for Testicular Seminoma With Limited Retroperitoneal Lymphadenopathy.
Daneshmand S, Cary C, Masterson T, Einhorn L, Adra N, Boorjian SA, Kollmannsberger C, Schuckman A, So A, Black P, Bagrodia A, Skinner E, Alemozaffar M, Brand T, Eggener S, Pierorazio P, Stratton K, Nappi L, Nichols C, Luo C, Li M, Hu B
J Clin Oncol 2023 Jun 1;41(16):3009-3018. Epub 2023 Mar 13 doi: 10.1200/JCO.22.00624. PMID: 36913642
Management of Low-Stage Testicular Seminoma.
Pearce SM, Liauw SL, Eggener SE
Urol Clin North Am 2015 Aug;42(3):287-98. Epub 2015 Jun 6 doi: 10.1016/j.ucl.2015.04.003. PMID: 26216816
Testicular germ-cell cancer.
Horwich A, Shipley J, Huddart R
Lancet 2006 Mar 4;367(9512):754-65. doi: 10.1016/S0140-6736(06)68305-0. PMID: 16517276
Early-stage testis cancer.
Foster RS
Curr Treat Options Oncol 2001 Oct;2(5):413-9. doi: 10.1007/s11864-001-0046-0. PMID: 12057104
International Germ Cell Consensus Classification: a prognostic factor-based staging system for metastatic germ cell cancers. International Germ Cell Cancer Collaborative Group.
J Clin Oncol 1997 Feb;15(2):594-603. doi: 10.1200/JCO.1997.15.2.594. PMID: 9053482

Prognosis

Testicular seminoma and non-seminoma: ESMO-EURACAN Clinical Practice Guideline for diagnosis, treatment and follow-up.
Oldenburg J, Berney DM, Bokemeyer C, Climent MA, Daugaard G, Gietema JA, De Giorgi U, Haugnes HS, Huddart RA, Leão R, Sohaib A, Gillessen S, Powles T; ESMO Guidelines Committee. Electronic address: [email protected]; EURACAN
Ann Oncol 2022 Apr;33(4):362-375. Epub 2022 Jan 19 doi: 10.1016/j.annonc.2022.01.002. PMID: 35065204
Epidemiology and Diagnosis of Testis Cancer.
Stevenson SM, Lowrance WT
Urol Clin North Am 2015 Aug;42(3):269-75. Epub 2015 Jun 11 doi: 10.1016/j.ucl.2015.04.001. PMID: 26216814
HIV infection and neoplasia.
Schulz TF, Boshoff CH, Weiss RA
Lancet 1996 Aug 31;348(9027):587-91. doi: 10.1016/S0140-6736(95)11033-X. PMID: 8774574
Testicular cancer.
Forman D, Møller H
Cancer Surv 1994;19-20:323-41. PMID: 7534631
Primary mediastinal seminoma.
Aygun C, Slawson RG, Bajaj K, Salazar OM
Urology 1984 Feb;23(2):109-17. PMID: 6364524

Clinical prediction guides

Clinical Stage IIA-IIC Seminoma: Radiation Therapy versus Systemic Chemotherapy versus Retroperitoneal Lymph Node Dissection.
von Amsberg G, Hamilton R, Papachristofilou A
Oncol Res Treat 2018;41(6):360-363. Epub 2018 May 16 doi: 10.1159/000489408. PMID: 29763926
New treatments for stage I testicular cancer.
Nappi L, Nichols CR, Kollmannsberger CK
Clin Adv Hematol Oncol 2017 Aug;15(8):626-631. PMID: 28949950
Testicular cancer: seminoma.
Chung P, Warde P
BMJ Clin Evid 2011 Jan 25;2011 PMID: 21477387Free PMC Article
Testicular cancer.
MacVicar GR, Pienta KJ
Curr Opin Oncol 2004 May;16(3):253-6. doi: 10.1097/00001622-200405000-00011. PMID: 15069322
Testicular cancer.
Forman D, Møller H
Cancer Surv 1994;19-20:323-41. PMID: 7534631

Recent systematic reviews

Endocrine Disrupting Chemicals and Risk of Testicular Cancer: A Systematic Review and Meta-analysis.
Bräuner EV, Lim YH, Koch T, Uldbjerg CS, Gregersen LS, Pedersen MK, Frederiksen H, Petersen JH, Coull BA, Andersson AM, Hickey M, Skakkebæk NE, Hauser R, Juul A
J Clin Endocrinol Metab 2021 Nov 19;106(12):e4834-e4860. doi: 10.1210/clinem/dgab523. PMID: 34270734Free PMC Article
Cannabis exposure and risk of testicular cancer: a systematic review and meta-analysis.
Gurney J, Shaw C, Stanley J, Signal V, Sarfati D
BMC Cancer 2015 Nov 11;15:897. doi: 10.1186/s12885-015-1905-6. PMID: 26560314Free PMC Article
Etiologic differences between seminoma and nonseminoma of the testis: a systematic review of epidemiologic studies.
Stang A, Kuss O
Hematol Oncol Clin North Am 2011 Jun;25(3):473-86, vii. Epub 2011 Apr 15 doi: 10.1016/j.hoc.2011.03.003. PMID: 21570603
Testicular cancer: seminoma.
Chung P, Warde P
BMJ Clin Evid 2011 Jan 25;2011 PMID: 21477387Free PMC Article
Testicular cancer: seminoma.
Neal RD, Stuart N, Wilkinson C
BMJ Clin Evid 2007 Feb 1;2007 PMID: 19454048Free PMC Article

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      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Curated

    • NCCN, 2024
      NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®), Testicular Cancer, 2024

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    Reviews

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