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Germ cell neoplasia

MedGen UID:
867599
•Concept ID:
C4021985
•
Neoplastic Process
HPO: HP:0100728

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGerm cell neoplasia

Conditions with this feature

Testicular germ cell tumor 1
MedGen UID:
337402
•Concept ID:
C1846164
•
Neoplastic Process
See: Condition Record
Testicular germ cell tumor 1

Professional guidelines

PubMed

Testicular Germ Cell Tumors: Classification, Pathologic Features, Imaging Findings, and Management.
Katabathina VS, Vargas-Zapata D, Monge RA, Nazarullah A, Ganeshan D, Tammisetti V, Prasad SR
Radiographics 2021 Oct;41(6):1698-1716. doi: 10.1148/rg.2021210024. PMID: 34597218
Diagnosis and Management of Intratubular Germ Cell Neoplasia In Situ: A Systematic Review.
Gupta M, Cheaib JG, Patel HD, Sharma R, Zhang A, Bass EB, Pierorazio PM
J Urol 2020 Jul;204(1):33-41. Epub 2020 Jan 22 doi: 10.1097/JU.0000000000000758. PMID: 31967523
Difficult differential diagnoses in testicular pathology.
Ye H, Ulbright TM
Arch Pathol Lab Med 2012 Apr;136(4):435-46. doi: 10.5858/arpa.2011-0475-RA. PMID: 22458906

Recent clinical studies

Etiology

The 2022 World Health Organization Classification of Tumours of the Urinary System and Male Genital Organs-Part A: Renal, Penile, and Testicular Tumours.
Moch H, Amin MB, Berney DM, Compérat EM, Gill AJ, Hartmann A, Menon S, Raspollini MR, Rubin MA, Srigley JR, Hoon Tan P, Tickoo SK, Tsuzuki T, Turajlic S, Cree I, Netto GJ
Eur Urol 2022 Nov;82(5):458-468. Epub 2022 Jul 16 doi: 10.1016/j.eururo.2022.06.016. PMID: 35853783
Testicular Tumors: A Contemporary Update on Morphologic, Immunohistochemical and Molecular Features.
Al-Obaidy KI, Idrees MT
Adv Anat Pathol 2021 Jul 1;28(4):258-275. doi: 10.1097/PAP.0000000000000302. PMID: 33871428
Germ cell neoplasia in situ complicating 17β-hydroxysteroid dehydrogenase type 3 deficiency.
Folsom LJ, Hjaige M, Liu J, Eugster EA, Auchus RJ
Mol Cell Endocrinol 2019 Jun 1;489:3-8. Epub 2018 Nov 30 doi: 10.1016/j.mce.2018.11.014. PMID: 30508571Free PMC Article
Testicular cancer.
Cheng L, Albers P, Berney DM, Feldman DR, Daugaard G, Gilligan T, Looijenga LHJ
Nat Rev Dis Primers 2018 Oct 5;4(1):29. doi: 10.1038/s41572-018-0029-0. PMID: 30291251
Update on the Pathophysiology and Risk Factors for the Development of Malignant Testicular Germ Cell Tumors in Complete Androgen Insensitivity Syndrome.
Cools M, Looijenga L
Sex Dev 2017;11(4):175-181. Epub 2017 Jul 19 doi: 10.1159/000477921. PMID: 28719895

Diagnosis

The 2022 World Health Organization Classification of Tumours of the Urinary System and Male Genital Organs-Part A: Renal, Penile, and Testicular Tumours.
Moch H, Amin MB, Berney DM, Compérat EM, Gill AJ, Hartmann A, Menon S, Raspollini MR, Rubin MA, Srigley JR, Hoon Tan P, Tickoo SK, Tsuzuki T, Turajlic S, Cree I, Netto GJ
Eur Urol 2022 Nov;82(5):458-468. Epub 2022 Jul 16 doi: 10.1016/j.eururo.2022.06.016. PMID: 35853783
An introduction to the WHO 5th edition 2022 classification of testicular tumours.
Berney DM, Cree I, Rao V, Moch H, Srigley JR, Tsuzuki T, Amin MB, Comperat EM, Hartmann A, Menon S, Netto GJ, Rubin MA, Turajlic S, Raspollini MR, Tickoo SK
Histopathology 2022 Oct;81(4):459-466. Epub 2022 Jul 1 doi: 10.1111/his.14675. PMID: 35502823Free PMC Article
Testicular Tumors: A Contemporary Update on Morphologic, Immunohistochemical and Molecular Features.
Al-Obaidy KI, Idrees MT
Adv Anat Pathol 2021 Jul 1;28(4):258-275. doi: 10.1097/PAP.0000000000000302. PMID: 33871428
Germ cell neoplasia in situ complicating 17β-hydroxysteroid dehydrogenase type 3 deficiency.
Folsom LJ, Hjaige M, Liu J, Eugster EA, Auchus RJ
Mol Cell Endocrinol 2019 Jun 1;489:3-8. Epub 2018 Nov 30 doi: 10.1016/j.mce.2018.11.014. PMID: 30508571Free PMC Article
Testicular cancer.
Cheng L, Albers P, Berney DM, Feldman DR, Daugaard G, Gilligan T, Looijenga LHJ
Nat Rev Dis Primers 2018 Oct 5;4(1):29. doi: 10.1038/s41572-018-0029-0. PMID: 30291251

Therapy

The relationship between testicular tumour characteristics and azoospermia: a systematic review.
Pang KH, Osman NI, Muneer A, Alnajjar HM
Int J Impot Res 2022 Sep;34(6):543-551. Epub 2021 Nov 6 doi: 10.1038/s41443-021-00492-x. PMID: 34743192
Current knowledge of risk factors for testicular germ cell tumors.
Fukawa T, Kanayama HO
Int J Urol 2018 Apr;25(4):337-344. Epub 2018 Jan 17 doi: 10.1111/iju.13519. PMID: 29345008
Postchemotherapy changes in testicular germ cell tumours: biology and morphology.
Berney DM, Lu YJ, Shamash J, Idrees M
Histopathology 2017 Jan;70(1):26-39. doi: 10.1111/his.13078. PMID: 27960240
Long-Term Follow-Up after Treatment of Cryptorchidism.
Thorup J, Cortes D
Eur J Pediatr Surg 2016 Oct;26(5):427-431. Epub 2016 Sep 2 doi: 10.1055/s-0036-1592138. PMID: 27589079
A Brief Review of the Link between Environment and Male Reproductive Health: Lessons from Studies of Testicular Germ Cell Cancer.
Skakkebaek NE
Horm Res Paediatr 2016;86(4):240-246. Epub 2016 Feb 13 doi: 10.1159/000443400. PMID: 26871895

Prognosis

An introduction to the WHO 5th edition 2022 classification of testicular tumours.
Berney DM, Cree I, Rao V, Moch H, Srigley JR, Tsuzuki T, Amin MB, Comperat EM, Hartmann A, Menon S, Netto GJ, Rubin MA, Turajlic S, Raspollini MR, Tickoo SK
Histopathology 2022 Oct;81(4):459-466. Epub 2022 Jul 1 doi: 10.1111/his.14675. PMID: 35502823Free PMC Article
Testicular cancer.
Cheng L, Albers P, Berney DM, Feldman DR, Daugaard G, Gilligan T, Looijenga LHJ
Nat Rev Dis Primers 2018 Oct 5;4(1):29. doi: 10.1038/s41572-018-0029-0. PMID: 30291251
Update on the Pathophysiology and Risk Factors for the Development of Malignant Testicular Germ Cell Tumors in Complete Androgen Insensitivity Syndrome.
Cools M, Looijenga L
Sex Dev 2017;11(4):175-181. Epub 2017 Jul 19 doi: 10.1159/000477921. PMID: 28719895
Perspectives on testicular germ cell neoplasms.
Cheng L, Lyu B, Roth LM
Hum Pathol 2017 Jan;59:10-25. Epub 2016 Aug 26 doi: 10.1016/j.humpath.2016.08.002. PMID: 27569298
Gonadal and extragonadal germ cell neoplasia of childhood.
Dehner LP
Hum Pathol 1983 Jun;14(6):493-511. doi: 10.1016/s0046-8177(83)80004-5. PMID: 6343221

Clinical prediction guides

The Role of miRNA in Testicular Cancer: Current Insights and Future Perspectives.
Ditonno F, Franco A, Manfredi C, Fasanella D, Abate M, La Rocca R, Crocerossa F, Iossa V, Falagario UG, Cirillo L, Altieri VM, Di Mauro E, Crocetto F, Barone B, Cilio S, Pandolfo SD, Aveta A, Mirone V, Franzese CA, Arcaniolo D, Napolitano L
Medicina (Kaunas) 2023 Nov 17;59(11) doi: 10.3390/medicina59112033. PMID: 38004082Free PMC Article
Application of miRNAs in the diagnosis and monitoring of testicular germ cell tumours.
Almstrup K, Lobo J, Mørup N, Belge G, Rajpert-De Meyts E, Looijenga LHJ, Dieckmann KP
Nat Rev Urol 2020 Apr;17(4):201-213. Epub 2020 Mar 10 doi: 10.1038/s41585-020-0296-x. PMID: 32157202
Perspectives on testicular germ cell neoplasms.
Cheng L, Lyu B, Roth LM
Hum Pathol 2017 Jan;59:10-25. Epub 2016 Aug 26 doi: 10.1016/j.humpath.2016.08.002. PMID: 27569298
Gonadal maldevelopment as risk factor for germ cell cancer: towards a clinical decision model.
van der Zwan YG, Biermann K, Wolffenbuttel KP, Cools M, Looijenga LH
Eur Urol 2015 Apr;67(4):692-701. Epub 2014 Sep 18 doi: 10.1016/j.eururo.2014.07.011. PMID: 25240975
The Rev/Rex homolog HERV-K cORF multimerizes via a C-terminal domain.
Boese A, Galli U, Geyer M, Sauter M, Mueller-Lantzsch N
FEBS Lett 2001 Mar 30;493(2-3):117-21. doi: 10.1016/s0014-5793(01)02280-3. PMID: 11287007

Recent systematic reviews

Oncological and functional outcomes after testis-sparing surgery in patients with germ cell tumors: a systematic review of 285 cases.
Grogg JB, Dursun ZH, Beyer J, Eberli D, Poyet C, Hermanns T, Fankhauser CD
World J Urol 2022 Sep;40(9):2293-2303. Epub 2022 Jul 12 doi: 10.1007/s00345-022-04048-6. PMID: 35821265Free PMC Article
The relationship between testicular tumour characteristics and azoospermia: a systematic review.
Pang KH, Osman NI, Muneer A, Alnajjar HM
Int J Impot Res 2022 Sep;34(6):543-551. Epub 2021 Nov 6 doi: 10.1038/s41443-021-00492-x. PMID: 34743192
Diagnosis and Management of Intratubular Germ Cell Neoplasia In Situ: A Systematic Review.
Gupta M, Cheaib JG, Patel HD, Sharma R, Zhang A, Bass EB, Pierorazio PM
J Urol 2020 Jul;204(1):33-41. Epub 2020 Jan 22 doi: 10.1097/JU.0000000000000758. PMID: 31967523
Germ Cell Tumors in Dysgenetic Gonads.
Piazza MJ, Urbanetz AA
Clinics (Sao Paulo) 2019;74:e408. Epub 2019 Nov 11 doi: 10.6061/clinics/2019/e408. PMID: 31721911Free PMC Article
Paratesticular seminoma: echographic features and histological diagnosis with review of the literature.
Palicelli A, Neri P, Marchioro G, De Angelis P, Bondonno G, Ramponi A
APMIS 2018 Mar;126(3):267-272. Epub 2018 Feb 7 doi: 10.1111/apm.12806. PMID: 29411910

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