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Speech disorder

MedGen UID:
11531
•Concept ID:
C0037822
•
Disease or Syndrome
Synonym: Speech Disorders
 
Monarch Initiative: MONDO:0004730

Definition

A term referring to disorders characterized by the disruption of normal speech. It includes stuttering, lisps, dysarthria and voice disorders. [from NCI]

Professional guidelines

PubMed

Speech disorders in Parkinson's disease: pathophysiology, medical management and surgical approaches.
Dashtipour K, Tafreshi A, Lee J, Crawley B
Neurodegener Dis Manag 2018 Oct;8(5):337-348. Epub 2018 Sep 18 doi: 10.2217/nmt-2018-0021. PMID: 30223711
Contemporary Approaches to the Management of Post-stroke Apraxia of Speech.
Basilakos A
Semin Speech Lang 2018 Feb;39(1):25-36. Epub 2018 Jan 22 doi: 10.1055/s-0037-1608853. PMID: 29359303Free PMC Article
Steroid-responsive encephalopathy associated with autoimmune thyroiditis (SREAT): Characteristics, treatment and outcome in 251 cases from the literature.
Laurent C, Capron J, Quillerou B, Thomas G, Alamowitch S, Fain O, Mekinian A
Autoimmun Rev 2016 Dec;15(12):1129-1133. Epub 2016 Sep 15 doi: 10.1016/j.autrev.2016.09.008. PMID: 27639840

Recent clinical studies

Etiology

Infant microbes and metabolites point to childhood neurodevelopmental disorders.
Ahrens AP, Hyötyläinen T, Petrone JR, Igelström K, George CD, Garrett TJ, Orešič M, Triplett EW, Ludvigsson J
Cell 2024 Apr 11;187(8):1853-1873.e15. Epub 2024 Apr 3 doi: 10.1016/j.cell.2024.02.035. PMID: 38574728
Snijders Blok-Campeau Syndrome: Description of 20 Additional Individuals with Variants in CHD3 and Literature Review.
Pascual P, Tenorio-Castano J, Mignot C, Afenjar A, Arias P, Gallego-Zazo N, Parra A, Miranda L, Cazalla M, Silván C, Heron D, Keren B, Popa I, Palomares M, Rikeros E, Ramos FJ, Almoguera B, Ayuso C, Swafiri ST, Barbero AIS, Srinivasan VM, Gowda VK, Morleo M, Nigro V, D'Arrigo S, Ciaccio C, Martin Mesa C, Paumard B, Guillen G, Anton ATS, Jimenez MD, Seidel V, Suárez J, Cormier-Daire V, Consortium TS, Nevado J, Lapunzina P
Genes (Basel) 2023 Aug 23;14(9) doi: 10.3390/genes14091664. PMID: 37761804Free PMC Article
Cerebellar mutism syndrome.
Catsman-Berrevoets C, Patay Z
Handb Clin Neurol 2018;155:273-288. doi: 10.1016/B978-0-444-64189-2.00018-4. PMID: 29891065
Consensus Paper: Revisiting the Symptoms and Signs of Cerebellar Syndrome.
Bodranghien F, Bastian A, Casali C, Hallett M, Louis ED, Manto M, Mariën P, Nowak DA, Schmahmann JD, Serrao M, Steiner KM, Strupp M, Tilikete C, Timmann D, van Dun K
Cerebellum 2016 Jun;15(3):369-91. doi: 10.1007/s12311-015-0687-3. PMID: 26105056Free PMC Article
Disorders of communication: dysarthria.
Enderby P
Handb Clin Neurol 2013;110:273-81. doi: 10.1016/B978-0-444-52901-5.00022-8. PMID: 23312647

Diagnosis

Infant microbes and metabolites point to childhood neurodevelopmental disorders.
Ahrens AP, Hyötyläinen T, Petrone JR, Igelström K, George CD, Garrett TJ, Orešič M, Triplett EW, Ludvigsson J
Cell 2024 Apr 11;187(8):1853-1873.e15. Epub 2024 Apr 3 doi: 10.1016/j.cell.2024.02.035. PMID: 38574728
An Update on Apraxia of Speech.
Utianski RL, Josephs KA
Curr Neurol Neurosci Rep 2023 Jul;23(7):353-359. Epub 2023 Jun 3 doi: 10.1007/s11910-023-01275-1. PMID: 37269450Free PMC Article
Primary Progressive Aphasias and Apraxia of Speech.
Botha H, Josephs KA
Continuum (Minneap Minn) 2019 Feb;25(1):101-127. doi: 10.1212/CON.0000000000000699. PMID: 30707189Free PMC Article
Stuttering: Clinical and research update.
Perez HR, Stoeckle JH
Can Fam Physician 2016 Jun;62(6):479-84. PMID: 27303004Free PMC Article
Disorders of communication: dysarthria.
Enderby P
Handb Clin Neurol 2013;110:273-81. doi: 10.1016/B978-0-444-52901-5.00022-8. PMID: 23312647

Therapy

The effect of ankyloglossia and tongue-tie division on speech articulation: A systematic review.
Wang J, Yang X, Hao S, Wang Y
Int J Paediatr Dent 2022 Mar;32(2):144-156. Epub 2021 May 22 doi: 10.1111/ipd.12802. PMID: 33964037
Cerebellar mutism syndrome.
Catsman-Berrevoets C, Patay Z
Handb Clin Neurol 2018;155:273-288. doi: 10.1016/B978-0-444-64189-2.00018-4. PMID: 29891065
Steroid-responsive encephalopathy associated with autoimmune thyroiditis (SREAT): Characteristics, treatment and outcome in 251 cases from the literature.
Laurent C, Capron J, Quillerou B, Thomas G, Alamowitch S, Fain O, Mekinian A
Autoimmun Rev 2016 Dec;15(12):1129-1133. Epub 2016 Sep 15 doi: 10.1016/j.autrev.2016.09.008. PMID: 27639840
Stuttering: Clinical and research update.
Perez HR, Stoeckle JH
Can Fam Physician 2016 Jun;62(6):479-84. PMID: 27303004Free PMC Article
Treatment for speech disorder in Friedreich ataxia and other hereditary ataxia syndromes.
Vogel AP, Folker J, Poole ML
Cochrane Database Syst Rev 2014 Oct 28;2014(10):CD008953. doi: 10.1002/14651858.CD008953.pub2. PMID: 25348587Free PMC Article

Prognosis

Infant microbes and metabolites point to childhood neurodevelopmental disorders.
Ahrens AP, Hyötyläinen T, Petrone JR, Igelström K, George CD, Garrett TJ, Orešič M, Triplett EW, Ludvigsson J
Cell 2024 Apr 11;187(8):1853-1873.e15. Epub 2024 Apr 3 doi: 10.1016/j.cell.2024.02.035. PMID: 38574728
Snijders Blok-Campeau Syndrome: Description of 20 Additional Individuals with Variants in CHD3 and Literature Review.
Pascual P, Tenorio-Castano J, Mignot C, Afenjar A, Arias P, Gallego-Zazo N, Parra A, Miranda L, Cazalla M, Silván C, Heron D, Keren B, Popa I, Palomares M, Rikeros E, Ramos FJ, Almoguera B, Ayuso C, Swafiri ST, Barbero AIS, Srinivasan VM, Gowda VK, Morleo M, Nigro V, D'Arrigo S, Ciaccio C, Martin Mesa C, Paumard B, Guillen G, Anton ATS, Jimenez MD, Seidel V, Suárez J, Cormier-Daire V, Consortium TS, Nevado J, Lapunzina P
Genes (Basel) 2023 Aug 23;14(9) doi: 10.3390/genes14091664. PMID: 37761804Free PMC Article
Speech in prodromal and symptomatic Huntington's disease as a model of measuring onset and progression in dominantly inherited neurodegenerative diseases.
Chan JCS, Stout JC, Vogel AP
Neurosci Biobehav Rev 2019 Dec;107:450-460. Epub 2019 Aug 13 doi: 10.1016/j.neubiorev.2019.08.009. PMID: 31419452
Primary Progressive Aphasias and Apraxia of Speech.
Botha H, Josephs KA
Continuum (Minneap Minn) 2019 Feb;25(1):101-127. doi: 10.1212/CON.0000000000000699. PMID: 30707189Free PMC Article
What causes stuttering?
Büchel C, Sommer M
PLoS Biol 2004 Feb;2(2):E46. Epub 2004 Feb 17 doi: 10.1371/journal.pbio.0020046. PMID: 14966540Free PMC Article

Clinical prediction guides

Infant microbes and metabolites point to childhood neurodevelopmental disorders.
Ahrens AP, Hyötyläinen T, Petrone JR, Igelström K, George CD, Garrett TJ, Orešič M, Triplett EW, Ludvigsson J
Cell 2024 Apr 11;187(8):1853-1873.e15. Epub 2024 Apr 3 doi: 10.1016/j.cell.2024.02.035. PMID: 38574728
Stuttering associated with a pathogenic variant in the chaperone protein cyclophilin 40.
Morgan AT, Scerri TS, Vogel AP, Reid CA, Quach M, Jackson VE, McKenzie C, Burrows EL, Bennett MF, Turner SJ, Reilly S, Horton SE, Block S, Kefalianos E, Frigerio-Domingues C, Sainz E, Rigbye KA, Featherby TJ, Richards KL, Kueh A, Herold MJ, Corbett MA, Gecz J, Helbig I, Thompson-Lake DGY, Liégeois FJ, Morell RJ, Hung A, Drayna D, Scheffer IE, Wright DK, Bahlo M, Hildebrand MS
Brain 2023 Dec 1;146(12):5086-5097. doi: 10.1093/brain/awad314. PMID: 37977818Free PMC Article
Snijders Blok-Campeau Syndrome: Description of 20 Additional Individuals with Variants in CHD3 and Literature Review.
Pascual P, Tenorio-Castano J, Mignot C, Afenjar A, Arias P, Gallego-Zazo N, Parra A, Miranda L, Cazalla M, Silván C, Heron D, Keren B, Popa I, Palomares M, Rikeros E, Ramos FJ, Almoguera B, Ayuso C, Swafiri ST, Barbero AIS, Srinivasan VM, Gowda VK, Morleo M, Nigro V, D'Arrigo S, Ciaccio C, Martin Mesa C, Paumard B, Guillen G, Anton ATS, Jimenez MD, Seidel V, Suárez J, Cormier-Daire V, Consortium TS, Nevado J, Lapunzina P
Genes (Basel) 2023 Aug 23;14(9) doi: 10.3390/genes14091664. PMID: 37761804Free PMC Article
The effect of ankyloglossia and tongue-tie division on speech articulation: A systematic review.
Wang J, Yang X, Hao S, Wang Y
Int J Paediatr Dent 2022 Mar;32(2):144-156. Epub 2021 May 22 doi: 10.1111/ipd.12802. PMID: 33964037
Consensus Paper: Revisiting the Symptoms and Signs of Cerebellar Syndrome.
Bodranghien F, Bastian A, Casali C, Hallett M, Louis ED, Manto M, Mariën P, Nowak DA, Schmahmann JD, Serrao M, Steiner KM, Strupp M, Tilikete C, Timmann D, van Dun K
Cerebellum 2016 Jun;15(3):369-91. doi: 10.1007/s12311-015-0687-3. PMID: 26105056Free PMC Article

Recent systematic reviews

The effect of ankyloglossia and tongue-tie division on speech articulation: A systematic review.
Wang J, Yang X, Hao S, Wang Y
Int J Paediatr Dent 2022 Mar;32(2):144-156. Epub 2021 May 22 doi: 10.1111/ipd.12802. PMID: 33964037
The Relationship between Feeding and Non-Nutritive Sucking Behaviours and Speech Sound Development: A Systematic Review.
Burr S, Harding S, Wren Y, Deave T
Folia Phoniatr Logop 2021;73(2):75-88. Epub 2020 Feb 10 doi: 10.1159/000505266. PMID: 32040950
Effects of oral and oropharyngeal cancer on speech intelligibility using acoustic analysis: Systematic review.
Balaguer M, Pommée T, Farinas J, Pinquier J, Woisard V, Speyer R
Head Neck 2020 Jan;42(1):111-130. Epub 2019 Sep 30 doi: 10.1002/hed.25949. PMID: 31571334
Steroid-responsive encephalopathy associated with autoimmune thyroiditis (SREAT): Characteristics, treatment and outcome in 251 cases from the literature.
Laurent C, Capron J, Quillerou B, Thomas G, Alamowitch S, Fain O, Mekinian A
Autoimmun Rev 2016 Dec;15(12):1129-1133. Epub 2016 Sep 15 doi: 10.1016/j.autrev.2016.09.008. PMID: 27639840
Treatment for speech disorder in Friedreich ataxia and other hereditary ataxia syndromes.
Vogel AP, Folker J, Poole ML
Cochrane Database Syst Rev 2014 Oct 28;2014(10):CD008953. doi: 10.1002/14651858.CD008953.pub2. PMID: 25348587Free PMC Article

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