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Neurologic Manifestations

MedGen UID:
18017
•Concept ID:
C0027854
•
Finding
Synonyms: Manifestation, Neurologic; Manifestation, Neurological; Manifestations, Neurologic; Manifestations, Neurological; Neurologic Manifestation; Neurologic Signs and Symptoms; Neurological Manifestation; Neurological Manifestations

Definition

Clinical signs and symptoms caused by nervous system injury or dysfunction. [from MeSH]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNeurologic Manifestations

Professional guidelines

PubMed

Diagnosis and management of glycogen storage disease type IV, including adult polyglucosan body disease: A clinical practice resource.
Koch RL, Soler-Alfonso C, Kiely BT, Asai A, Smith AL, Bali DS, Kang PB, Landstrom AP, Akman HO, Burrow TA, Orthmann-Murphy JL, Goldman DS, Pendyal S, El-Gharbawy AH, Austin SL, Case LE, Schiffmann R, Hirano M, Kishnani PS
Mol Genet Metab 2023 Mar;138(3):107525. Epub 2023 Jan 25 doi: 10.1016/j.ymgme.2023.107525. PMID: 36796138
Diagnosing antiphospholipid syndrome: 'extra-criteria' manifestations and technical advances.
Sciascia S, Amigo MC, Roccatello D, Khamashta M
Nat Rev Rheumatol 2017 Sep;13(9):548-560. Epub 2017 Aug 3 doi: 10.1038/nrrheum.2017.124. PMID: 28769114
TREATMENT OF ANURIA.
ROSSWICK RP
Curr Med Drugs 1964 Mar;4(7):3-11. PMID: 14129529

Recent clinical studies

Etiology

Neurologic Manifestations of the Antiphospholipid Syndrome - an Update.
Leal Rato M, Bandeira M, Romão VC, Aguiar de Sousa D
Curr Neurol Neurosci Rep 2021 Jun 14;21(8):41. doi: 10.1007/s11910-021-01124-z. PMID: 34125304Free PMC Article
Neurologic Manifestations of Hospitalized Patients With Coronavirus Disease 2019 in Wuhan, China.
Mao L, Jin H, Wang M, Hu Y, Chen S, He Q, Chang J, Hong C, Zhou Y, Wang D, Miao X, Li Y, Hu B
JAMA Neurol 2020 Jun 1;77(6):683-690. doi: 10.1001/jamaneurol.2020.1127. PMID: 32275288Free PMC Article
Neurologic manifestations of diphtheria and pertussis.
Sanghi V
Handb Clin Neurol 2014;121:1355-9. doi: 10.1016/B978-0-7020-4088-7.00092-4. PMID: 24365424
The neurology of folic acid deficiency.
Reynolds EH
Handb Clin Neurol 2014;120:927-43. doi: 10.1016/B978-0-7020-4087-0.00061-9. PMID: 24365361
Porphyria and its neurologic manifestations.
Tracy JA, Dyck PJ
Handb Clin Neurol 2014;120:839-49. doi: 10.1016/B978-0-7020-4087-0.00056-5. PMID: 24365356

Diagnosis

Neurologic Manifestations of Hospitalized Patients With Coronavirus Disease 2019 in Wuhan, China.
Mao L, Jin H, Wang M, Hu Y, Chen S, He Q, Chang J, Hong C, Zhou Y, Wang D, Miao X, Li Y, Hu B
JAMA Neurol 2020 Jun 1;77(6):683-690. doi: 10.1001/jamaneurol.2020.1127. PMID: 32275288Free PMC Article
Neurologic Manifestations of Rheumatic Diseases.
Weisman MH
Rheum Dis Clin North Am 2017 Nov;43(4):xi. doi: 10.1016/j.rdc.2017.08.002. PMID: 29061249
Neurologic Manifestations of Rheumatoid Arthritis.
DeQuattro K, Imboden JB
Rheum Dis Clin North Am 2017 Nov;43(4):561-571. Epub 2017 Aug 31 doi: 10.1016/j.rdc.2017.06.005. PMID: 29061242
Neurologic Manifestations of Primary Sjögren Syndrome.
Margaretten M
Rheum Dis Clin North Am 2017 Nov;43(4):519-529. Epub 2017 Aug 23 doi: 10.1016/j.rdc.2017.06.002. PMID: 29061239
SACROILIAC STRAIN.
JOHNSON JW
J Am Osteopath Assoc 1964 Jul;63:1015-29. PMID: 14181589

Therapy

Spirochetal infection of the nervous system.
Estanislao LB, Pachner AR
Neurol Clin 1999 Nov;17(4):783-800. doi: 10.1016/s0733-8619(05)70166-3. PMID: 10517928
Arsenic poisoning.
Schoolmeester WL, White DR
South Med J 1980 Feb;73(2):198-208. doi: 10.1097/00007611-198002000-00021. PMID: 7355321
Cryptococcal chorioretinitis.
Shields JA, Wright DM, Augsburger JJ, Wolkowicz MI
Am J Ophthalmol 1980 Feb;89(2):210-7. doi: 10.1016/0002-9394(80)90113-0. PMID: 6965566
Fat embolism.
Lancet 1972 Mar 25;1(7752):672-3. PMID: 4125169
Neurosarcoidosis.
James DG, Sharma OP
Proc R Soc Med 1967 Nov 1;60(11 Part 1):1169-70. PMID: 6060718Free PMC Article

Prognosis

Sarcoidosis.
Cooper D, Suau S
Immunol Allergy Clin North Am 2023 Aug;43(3):583-591. doi: 10.1016/j.iac.2022.10.011. PMID: 37394261
Polyarteritis Nodosa Neurologic Manifestations.
de Boysson H, Guillevin L
Neurol Clin 2019 May;37(2):345-357. Epub 2019 Mar 16 doi: 10.1016/j.ncl.2019.01.007. PMID: 30952413
Trigeminal neurinomas.
Fee WE Jr, Epsy CD, Konrad HR
Laryngoscope 1975 Feb;85(2):371-6. doi: 10.1288/00005537-197502000-00014. PMID: 1113604
Infectious mononucleosis.
Fernbach DJ, Starling KA
Pediatr Clin North Am 1972 Nov;19(4):957-68. doi: 10.1016/s0031-3955(16)32776-6. PMID: 4343069
Generalized lipodystrophy.
Seip M
Ergeb Inn Med Kinderheilkd 1971;31:59-95. doi: 10.1007/978-3-642-65213-4_2. PMID: 4933543

Clinical prediction guides

Acute Neurological Complications of Coronavirus Disease.
Chang S, Schecht M, Jain R, Belani P
Neuroimaging Clin N Am 2023 Feb;33(1):57-68. Epub 2022 Jul 18 doi: 10.1016/j.nic.2022.07.003. PMID: 36404047Free PMC Article
Clinical Presentation, Risk Factors, and Outcomes of Immune Effector Cell-Associated Neurotoxicity Syndrome Following Chimeric Antigen Receptor T Cell Therapy: A Systematic Review.
Grant SJ, Grimshaw AA, Silberstein J, Murdaugh D, Wildes TM, Rosko AE, Giri S
Transplant Cell Ther 2022 Jun;28(6):294-302. Epub 2022 Mar 11 doi: 10.1016/j.jtct.2022.03.006. PMID: 35288347Free PMC Article
Neurologic Manifestations of Hospitalized Patients With Coronavirus Disease 2019 in Wuhan, China.
Mao L, Jin H, Wang M, Hu Y, Chen S, He Q, Chang J, Hong C, Zhou Y, Wang D, Miao X, Li Y, Hu B
JAMA Neurol 2020 Jun 1;77(6):683-690. doi: 10.1001/jamaneurol.2020.1127. PMID: 32275288Free PMC Article
Neuroborreliosis.
Halperin JJ
Neurol Clin 2018 Nov;36(4):821-830. doi: 10.1016/j.ncl.2018.06.006. PMID: 30366557
Lightning injuries.
Cwinn AA, Cantrill SV
J Emerg Med 1985;2(5):379-88. doi: 10.1016/0736-4679(85)90294-x. PMID: 3910718

Recent systematic reviews

Clinical Presentation, Risk Factors, and Outcomes of Immune Effector Cell-Associated Neurotoxicity Syndrome Following Chimeric Antigen Receptor T Cell Therapy: A Systematic Review.
Grant SJ, Grimshaw AA, Silberstein J, Murdaugh D, Wildes TM, Rosko AE, Giri S
Transplant Cell Ther 2022 Jun;28(6):294-302. Epub 2022 Mar 11 doi: 10.1016/j.jtct.2022.03.006. PMID: 35288347Free PMC Article
Unusual neurologic manifestations of Vogt-Koyanagi-Harada disease: a systematic literature review.
Toudou-Daouda M, Ibrahim-Mamadou AK
BMC Neurol 2022 Feb 4;22(1):44. doi: 10.1186/s12883-022-02569-6. PMID: 35120474Free PMC Article
A systematic review and meta-analysis of the association between fluoride exposure and neurological disorders.
Miranda GHN, Alvarenga MOP, Ferreira MKM, Puty B, Bittencourt LO, Fagundes NCF, Pessan JP, Buzalaf MAR, Lima RR
Sci Rep 2021 Nov 22;11(1):22659. doi: 10.1038/s41598-021-99688-w. PMID: 34811523Free PMC Article
Frequency of Neurologic Manifestations in COVID-19: A Systematic Review and Meta-analysis.
Misra S, Kolappa K, Prasad M, Radhakrishnan D, Thakur KT, Solomon T, Michael BD, Winkler AS, Beghi E, Guekht A, Pardo CA, Wood GK, Hsiang-Yi Chou S, Fink EL, Schmutzhard E, Kheradmand A, Hoo FK, Kumar A, Das A, Srivastava AK, Agarwal A, Dua T, Prasad K
Neurology 2021 Dec 7;97(23):e2269-e2281. Epub 2021 Oct 11 doi: 10.1212/WNL.0000000000012930. PMID: 34635561Free PMC Article
Fibromuscular Dysplasia and Its Neurologic Manifestations: A Systematic Review.
Touzé E, Southerland AM, Boulanger M, Labeyrie PE, Azizi M, Bouatia-Naji N, Debette S, Gornik HL, Hussain SM, Jeunemaitre X, Joux J, Kirton A, Le Hello C, Majersik JJ, Mocco J, Persu A, Sharma A, Worrall BB, Olin JW, Plouin PF
JAMA Neurol 2019 Feb 1;76(2):217-226. doi: 10.1001/jamaneurol.2018.2848. PMID: 30285053

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