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Adenofibroma

MedGen UID:
1325
•Concept ID:
C0001422
•
Neoplastic Process
Synonym: Adenofibromas
SNOMED CT: Benign adenofibroma (1157241000)
 
Monarch Initiative: MONDO:0006071

Definition

A benign neoplasm characterized by the presence of connective tissue stroma and epithelial structures. It occurs in the ovary, fallopian tube, uterine corpus, and cervix. Cases of adenofibroma of the ovary with low grade malignant potential have also been reported. [from MONDO]

Professional guidelines

PubMed

Mammotome biopsy under ultrasound control in the diagnostics and treatment of nodular breast lesions - own experience.
Kibil W, Hodorowicz-Zaniewska D, Kulig J
Pol Przegl Chir 2012 May;84(5):242-6. doi: 10.2478/v10035-012-0040-1. PMID: 22763299
Clear cell carcinoma of the ovary: is there a role of histology-specific treatment?
Takano M, Tsuda H, Sugiyama T
J Exp Clin Cancer Res 2012 Jun 1;31(1):53. doi: 10.1186/1756-9966-31-53. PMID: 22655678Free PMC Article
Uterine adenosarcoma: a clinicopathologic study of 11 cases with a reevaluation of histologic criteria.
Czernobilsky B, Hohlweg-Majert P, Dallenbach-Hellweg G
Arch Gynecol 1983;233(4):281-94. doi: 10.1007/BF02133803. PMID: 6318673

Recent clinical studies

Etiology

Robotic enucleation of a biliary adenofibroma.
Blears E, Uemura T, Bunker M
BMJ Case Rep 2021 Aug 10;14(8) doi: 10.1136/bcr-2021-242737. PMID: 34376413Free PMC Article
Fibroadenoma.
Dent DM, Cant PJ
World J Surg 1989 Nov-Dec;13(6):706-10. doi: 10.1007/BF01658418. PMID: 2696223
Radiation carcinogenesis in experimental animals and its implications for radiation protection.
Broerse JJ, Hennen LA, van Zwieten MJ
Int J Radiat Biol Relat Stud Phys Chem Med 1985 Aug;48(2):167-87. doi: 10.1080/09553008514551171. PMID: 3894267
Influence of oral contraceptives on breast diseases.
Fechner RE
Cancer 1977 Jun;39(6 Suppl):2764-71. doi: 10.1002/1097-0142(197706)39:6<2764::aid-cncr2820390664>3.0.co;2-i. PMID: 406035
Heterogeneity in gingival fibromatosis.
Witkop CJ Jr
Birth Defects Orig Artic Ser 1971 Jun;7(7):210-21. PMID: 4950923

Diagnosis

Metanephric adenofibroma.
Turner Ii RM, Tomaszewski JJ, Fox JA, Galambos C, Cannon GM Jr
Can J Urol 2013 Apr;20(2):6737-8. PMID: 23587517
Paratesticular adenofibroma.
Janane A, Ghadouane M, Alami M, Abbar M
Scand J Urol Nephrol 2003;37(2):179-80. doi: 10.1080/00365590310008956. PMID: 12745730
Mixed müllerian tumors.
Silverberg SG
Curr Top Pathol 1992;85:35-56. doi: 10.1007/978-3-642-75941-3_2. PMID: 1321027
Multiple, giant fibroadenoma.
Musio F, Mozingo D, Otchy DP
Am Surg 1991 Jul;57(7):438-41. PMID: 1647714
Tumorigenic aspects.
Kirk ME
Int J Gynaecol Obstet 1978-1979;16(6):473-8. doi: 10.1002/j.1879-3479.1979.tb00952.x. PMID: 39811

Therapy

Endometriosis-associated intestinal tumors: a clinical and pathological study of 6 cases with a review of the literature.
Slavin RE, Krum R, Van Dinh T
Hum Pathol 2000 Apr;31(4):456-63. doi: 10.1053/hp.2000.6712. PMID: 10821493
Breast cancer concepts.
Hatfield HA, Guthrie TH Jr
Am Fam Physician 1984 Aug;30(2):195-200. PMID: 6464959
Breast lumps.
Townsend CM Jr
Clin Symp 1980;32(2):1-32. PMID: 7018816
Tumorigenic aspects.
Kirk ME
Int J Gynaecol Obstet 1978-1979;16(6):473-8. doi: 10.1002/j.1879-3479.1979.tb00952.x. PMID: 39811
Influence of oral contraceptives on breast diseases.
Fechner RE
Cancer 1977 Jun;39(6 Suppl):2764-71. doi: 10.1002/1097-0142(197706)39:6<2764::aid-cncr2820390664>3.0.co;2-i. PMID: 406035

Prognosis

Robotic enucleation of a biliary adenofibroma.
Blears E, Uemura T, Bunker M
BMJ Case Rep 2021 Aug 10;14(8) doi: 10.1136/bcr-2021-242737. PMID: 34376413Free PMC Article
Mucinous Neoplasms of the Ovary: Radiologic-Pathologic Correlation.
Marko J, Marko KI, Pachigolla SL, Crothers BA, Mattu R, Wolfman DJ
Radiographics 2019 Jul-Aug;39(4):982-997. doi: 10.1148/rg.2019180221. PMID: 31283462Free PMC Article
Pathology of Endometrioid and Clear Cell Carcinoma of the Ovary.
Fadare O, Parkash V
Surg Pathol Clin 2019 Jun;12(2):529-564. doi: 10.1016/j.path.2019.01.009. PMID: 31097114
Synchronous Pulmonary Adenofibroma and Solitary Fibrous Tumor: Case Report and Review of the Literature.
Olson NJ, Czum JM, de Abreu FB, Linos K, Black CC
Int J Surg Pathol 2019 May;27(3):322-327. Epub 2018 Oct 26 doi: 10.1177/1066896918807302. PMID: 30360665
Mixed müllerian tumors.
Silverberg SG
Curr Top Pathol 1992;85:35-56. doi: 10.1007/978-3-642-75941-3_2. PMID: 1321027

Clinical prediction guides

Intrahepatic cholangiocarcinoma: typical features, uncommon variants, and controversial related entities.
Zen Y
Hum Pathol 2023 Feb;132:197-207. Epub 2022 Jun 11 doi: 10.1016/j.humpath.2022.06.001. PMID: 35697170
Robotic enucleation of a biliary adenofibroma.
Blears E, Uemura T, Bunker M
BMJ Case Rep 2021 Aug 10;14(8) doi: 10.1136/bcr-2021-242737. PMID: 34376413Free PMC Article
Molecular comparison of pure ovarian fibroma with serous benign ovarian tumours.
Hunter SM, Dall GV, Doyle MA, Lupat R, Li J, Allan P, Rowley SM, Bowtell D; AOCS, Campbell IG, Gorringe KL
BMC Res Notes 2020 Jul 22;13(1):349. doi: 10.1186/s13104-020-05194-z. PMID: 32698852Free PMC Article
Radiation carcinogenesis in experimental animals and its implications for radiation protection.
Broerse JJ, Hennen LA, van Zwieten MJ
Int J Radiat Biol Relat Stud Phys Chem Med 1985 Aug;48(2):167-87. doi: 10.1080/09553008514551171. PMID: 3894267
Breast masses in adolescent females.
Goldstein DP, Miler V
Clin Pediatr (Phila) 1982 Jan;21(1):17-9. doi: 10.1177/000992288202100102. PMID: 7055997

Recent systematic reviews

Imaging features of biliary adenofibroma of the liver with malignant transformation: a case report with literature review.
Hu W, Zhao Y, Liu Y, Hua Z, Liu A
BMC Med Imaging 2022 Mar 17;22(1):47. doi: 10.1186/s12880-022-00775-9. PMID: 35296268Free PMC Article

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