U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Clear cell adenofibroma

MedGen UID:
90762
•Concept ID:
C0334317
•
Neoplastic Process
Synonyms: Cystadenofibroma; Cystadenofibromas
 
Monarch Initiative: MONDO:0003460

Definition

A benign or borderline neoplasm that arises from the ovaries and the fallopian tubes. It is characterized by the presence of cystic glandular structures and fibrous tissue. [from NCI]

Professional guidelines

PubMed

Clear cell carcinoma of the ovary: is there a role of histology-specific treatment?
Takano M, Tsuda H, Sugiyama T
J Exp Clin Cancer Res 2012 Jun 1;31(1):53. doi: 10.1186/1756-9966-31-53. PMID: 22655678Free PMC Article

Recent clinical studies

Etiology

Clear cell carcinoma of the ovary: comparison of MR findings of histological subtypes.
Kato H, Hatano Y, Makino H, Furui T, Morishige KI, Matsuo M
Abdom Radiol (NY) 2016 Dec;41(12):2476-2483. doi: 10.1007/s00261-016-0777-9. PMID: 27167231
Clear cell carcinoma of the ovary: is there a role of histology-specific treatment?
Takano M, Tsuda H, Sugiyama T
J Exp Clin Cancer Res 2012 Jun 1;31(1):53. doi: 10.1186/1756-9966-31-53. PMID: 22655678Free PMC Article
An allelotype analysis indicating the presence of two distinct ovarian clear-cell carcinogenic pathways: endometriosis-associated pathway vs. clear-cell adenofibroma-associated pathway.
Yamamoto S, Tsuda H, Suzuki K, Takano M, Tamai S, Matsubara O
Virchows Arch 2009 Sep;455(3):261-70. Epub 2009 Aug 5 doi: 10.1007/s00428-009-0816-9. PMID: 19655165
Benign clear cell adenofibroma of the ovary. A case report with literature review.
Paşaoğlu O, Ciftçi E, Tel N, Ozalp S, Acikalin MF
Gynecol Obstet Invest 2007;64(1):36-9. Epub 2007 Jan 5 doi: 10.1159/000098425. PMID: 17202822
Ovarian clear cell adenofibromatous tumors. Benign, of low malignant potential, and associated with invasive clear cell carcinoma.
Roth LM, Langley FA, Fox H, Wheeler JE, Czernobilsky B
Cancer 1984 Mar 1;53(5):1156-63. doi: 10.1002/1097-0142(19840301)53:5<1156::aid-cncr2820530522>3.0.co;2-2. PMID: 6692303

Diagnosis

Mature cystic teratoma coexisting with clear-cell carcinoma in the ovary.
Shimura K, Matsumoto M, Sugahara T, Yamamoto T, Ogiso N, Urata Y, Okubo T
J Obstet Gynaecol Res 2017 Feb;43(2):408-411. Epub 2016 Dec 17 doi: 10.1111/jog.13224. PMID: 27987343
Clear cell carcinoma of the ovary: comparison of MR findings of histological subtypes.
Kato H, Hatano Y, Makino H, Furui T, Morishige KI, Matsuo M
Abdom Radiol (NY) 2016 Dec;41(12):2476-2483. doi: 10.1007/s00261-016-0777-9. PMID: 27167231
Napsin A is a specific marker for ovarian clear cell adenocarcinoma.
Yamashita Y, Nagasaka T, Naiki-Ito A, Sato S, Suzuki S, Toyokuni S, Ito M, Takahashi S
Mod Pathol 2015 Jan;28(1):111-7. Epub 2014 Apr 11 doi: 10.1038/modpathol.2014.61. PMID: 24721826
Clear cell carcinoma of the ovary: is there a role of histology-specific treatment?
Takano M, Tsuda H, Sugiyama T
J Exp Clin Cancer Res 2012 Jun 1;31(1):53. doi: 10.1186/1756-9966-31-53. PMID: 22655678Free PMC Article
Benign clear cell adenofibroma of the ovary. A case report with literature review.
Paşaoğlu O, Ciftçi E, Tel N, Ozalp S, Acikalin MF
Gynecol Obstet Invest 2007;64(1):36-9. Epub 2007 Jan 5 doi: 10.1159/000098425. PMID: 17202822

Therapy

Clear cell carcinoma of the ovary: is there a role of histology-specific treatment?
Takano M, Tsuda H, Sugiyama T
J Exp Clin Cancer Res 2012 Jun 1;31(1):53. doi: 10.1186/1756-9966-31-53. PMID: 22655678Free PMC Article

Prognosis

Napsin A is a specific marker for ovarian clear cell adenocarcinoma.
Yamashita Y, Nagasaka T, Naiki-Ito A, Sato S, Suzuki S, Toyokuni S, Ito M, Takahashi S
Mod Pathol 2015 Jan;28(1):111-7. Epub 2014 Apr 11 doi: 10.1038/modpathol.2014.61. PMID: 24721826
Clear cell carcinoma of the ovary: is there a role of histology-specific treatment?
Takano M, Tsuda H, Sugiyama T
J Exp Clin Cancer Res 2012 Jun 1;31(1):53. doi: 10.1186/1756-9966-31-53. PMID: 22655678Free PMC Article
Accumulative copy number increase of MET drives tumor development and histological progression in a subset of ovarian clear-cell adenocarcinomas.
Yamamoto S, Tsuda H, Miyai K, Takano M, Tamai S, Matsubara O
Mod Pathol 2012 Jan;25(1):122-30. Epub 2011 Oct 7 doi: 10.1038/modpathol.2011.143. PMID: 21983935
Benign clear cell adenofibroma of the ovary. A case report with literature review.
Paşaoğlu O, Ciftçi E, Tel N, Ozalp S, Acikalin MF
Gynecol Obstet Invest 2007;64(1):36-9. Epub 2007 Jan 5 doi: 10.1159/000098425. PMID: 17202822
Ovarian clear cell adenofibromatous tumors. Benign, of low malignant potential, and associated with invasive clear cell carcinoma.
Roth LM, Langley FA, Fox H, Wheeler JE, Czernobilsky B
Cancer 1984 Mar 1;53(5):1156-63. doi: 10.1002/1097-0142(19840301)53:5<1156::aid-cncr2820530522>3.0.co;2-2. PMID: 6692303

Clinical prediction guides

Pathologic Findings in Prophylactic and Nonprophylactic Hysterectomy Specimens of Patients With Lynch Syndrome.
Bartosch C, Pires-Luís AS, Meireles C, Baptista M, Gouveia A, Pinto C, Shannon KM, Jerónimo C, Teixeira MR, Lopes JM, Oliva E
Am J Surg Pathol 2016 Sep;40(9):1177-91. doi: 10.1097/PAS.0000000000000684. PMID: 27340747
Clear cell carcinoma of the ovary: comparison of MR findings of histological subtypes.
Kato H, Hatano Y, Makino H, Furui T, Morishige KI, Matsuo M
Abdom Radiol (NY) 2016 Dec;41(12):2476-2483. doi: 10.1007/s00261-016-0777-9. PMID: 27167231
Napsin A is a specific marker for ovarian clear cell adenocarcinoma.
Yamashita Y, Nagasaka T, Naiki-Ito A, Sato S, Suzuki S, Toyokuni S, Ito M, Takahashi S
Mod Pathol 2015 Jan;28(1):111-7. Epub 2014 Apr 11 doi: 10.1038/modpathol.2014.61. PMID: 24721826
Ovarian benign clear cell adenofibroma in a patient with premature ovarian failure after 8-year hormone replacement therapy.
Chen R, Zhou H, Zhang Y
Gynecol Endocrinol 2013 Mar;29(3):216-8. Epub 2012 Nov 16 doi: 10.3109/09513590.2012.736555. PMID: 23153077
PIK3CA mutations and loss of ARID1A protein expression are early events in the development of cystic ovarian clear cell adenocarcinoma.
Yamamoto S, Tsuda H, Takano M, Tamai S, Matsubara O
Virchows Arch 2012 Jan;460(1):77-87. Epub 2011 Nov 26 doi: 10.1007/s00428-011-1169-8. PMID: 22120431

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • MeSH
      Related Medical Subject Headings
    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...