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Aortic disorder

MedGen UID:
1618
•Concept ID:
C0003493
•
Disease or Syndrome
Synonym: Aortic disease
SNOMED CT: Disease of the aorta (47040006); Disorder of aorta (47040006)
 
Monarch Initiative: MONDO:0005561

Definition

Pathology involving the thoracic, thoracoabdominal, or abdominal aorta (including aneurysms). (ACC) [from NCI]

Professional guidelines

PubMed

2022 ACC/AHA Guideline for the Diagnosis and Management of Aortic Disease: A Report of the American Heart Association/American College of Cardiology Joint Committee on Clinical Practice Guidelines.
Isselbacher EM, Preventza O, Hamilton Black J 3rd, Augoustides JG, Beck AW, Bolen MA, Braverman AC, Bray BE, Brown-Zimmerman MM, Chen EP, Collins TJ, DeAnda A Jr, Fanola CL, Girardi LN, Hicks CW, Hui DS, Schuyler Jones W, Kalahasti V, Kim KM, Milewicz DM, Oderich GS, Ogbechie L, Promes SB, Gyang Ross E, Schermerhorn ML, Singleton Times S, Tseng EE, Wang GJ, Woo YJ; Peer Review Committee Members
Circulation 2022 Dec 13;146(24):e334-e482. Epub 2022 Nov 2 doi: 10.1161/CIR.0000000000001106. PMID: 36322642Free PMC Article
Lipoprotein(a) in atherosclerotic cardiovascular disease and aortic stenosis: a European Atherosclerosis Society consensus statement.
Kronenberg F, Mora S, Stroes ESG, Ference BA, Arsenault BJ, Berglund L, Dweck MR, Koschinsky M, Lambert G, Mach F, McNeal CJ, Moriarty PM, Natarajan P, Nordestgaard BG, Parhofer KG, Virani SS, von Eckardstein A, Watts GF, Stock JK, Ray KK, Tokgözoğlu LS, Catapano AL
Eur Heart J 2022 Oct 14;43(39):3925-3946. doi: 10.1093/eurheartj/ehac361. PMID: 36036785Free PMC Article
2020 ACC/AHA Guideline for the Management of Patients With Valvular Heart Disease: Executive Summary: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines.
Otto CM, Nishimura RA, Bonow RO, Carabello BA, Erwin JP 3rd, Gentile F, Jneid H, Krieger EV, Mack M, McLeod C, O'Gara PT, Rigolin VH, Sundt TM 3rd, Thompson A, Toly C
Circulation 2021 Feb 2;143(5):e35-e71. Epub 2020 Dec 17 doi: 10.1161/CIR.0000000000000932. PMID: 33332149

Recent clinical studies

Etiology

Genome-wide association study of thoracic aortic aneurysm and dissection in the Million Veteran Program.
Klarin D, Devineni P, Sendamarai AK, Angueira AR, Graham SE, Shen YH, Levin MG, Pirruccello JP, Surakka I, Karnam PR, Roychowdhury T, Li Y, Wang M, Aragam KG, Paruchuri K, Zuber V, Shakt GE, Tsao NL, Judy RL, Vy HMT, Verma SS, Rader DJ, Do R, Bavaria JE, Nadkarni GN, Ritchie MD; VA Million Veteran Program, Burgess S, Guo DC, Ellinor PT, LeMaire SA, Milewicz DM, Willer CJ, Natarajan P, Tsao PS, Pyarajan S, Damrauer SM
Nat Genet 2023 Jul;55(7):1106-1115. Epub 2023 Jun 12 doi: 10.1038/s41588-023-01420-z. PMID: 37308786Free PMC Article
Outcomes of valve-sparing surgery in heritable aortic disorders: results from the AVIATOR registry.
Chauvette V, Kluin J, de Kerchove L, El Khoury G, Schäfers HJ, Lansac E, El-Hamamsy I
Eur J Cardiothorac Surg 2022 Aug 3;62(3) doi: 10.1093/ejcts/ezac366. PMID: 35916717
Fever of unknown origin in aortic dissection.
Yuan SM
Z Rheumatol 2017 May;76(4):364-371. doi: 10.1007/s00393-016-0203-2. PMID: 27644955
Renal dysfunction and fluid and electrolyte disturbances.
Hashem R, Weissman C
Curr Opin Crit Care 2011 Aug;17(4):390-5. doi: 10.1097/MCC.0b013e328348bef5. PMID: 21716110
Suspected aortic dissection and other aortic disorders: multi-detector row CT in 373 cases in the emergency setting.
Hayter RG, Rhea JT, Small A, Tafazoli FS, Novelline RA
Radiology 2006 Mar;238(3):841-52. Epub 2006 Feb 1 doi: 10.1148/radiol.2383041528. PMID: 16452396

Diagnosis

Fever of unknown origin in aortic dissection.
Yuan SM
Z Rheumatol 2017 May;76(4):364-371. doi: 10.1007/s00393-016-0203-2. PMID: 27644955
Valve-sparing aortic root replacement in Loeys-Dietz syndrome.
Patel ND, Arnaoutakis GJ, George TJ, Allen JG, Alejo DE, Dietz HC, Cameron DE, Vricella LA
Ann Thorac Surg 2011 Aug;92(2):556-60; discussion 560-1. doi: 10.1016/j.athoracsur.2011.04.003. PMID: 21801912
Different clinical pictures of penetrating ulcer of the aorta, an underrated aortic disease.
Anselmi A, Luciani N, Perri G, Palladino M, Tsiopoulos V
J Cardiovasc Med (Hagerstown) 2010 Nov;11(11):815-9. doi: 10.2459/JCM.0b013e32833cdb96. PMID: 20639766
Three-dimensional contrast-enhanced MR angiography of aortic dissection: a pictorial essay.
Liu Q, Lu JP, Wang F, Wang L, Tian JM
Radiographics 2007 Sep-Oct;27(5):1311-21. doi: 10.1148/rg.275065737. PMID: 17848693
Suspected aortic dissection and other aortic disorders: multi-detector row CT in 373 cases in the emergency setting.
Hayter RG, Rhea JT, Small A, Tafazoli FS, Novelline RA
Radiology 2006 Mar;238(3):841-52. Epub 2006 Feb 1 doi: 10.1148/radiol.2383041528. PMID: 16452396

Therapy

Renal dysfunction and fluid and electrolyte disturbances.
Hashem R, Weissman C
Curr Opin Crit Care 2011 Aug;17(4):390-5. doi: 10.1097/MCC.0b013e328348bef5. PMID: 21716110

Prognosis

Clinical Characteristics of Aortic Aneurysm in MIMIC-III.
Song K, Guo C, Yang K, Li C, Ding N
Heart Surg Forum 2021 Apr 2;24(2):E351-E358. doi: 10.1532/hsf.3571. PMID: 33798047
Valve-sparing aortic root replacement in Loeys-Dietz syndrome.
Patel ND, Arnaoutakis GJ, George TJ, Allen JG, Alejo DE, Dietz HC, Cameron DE, Vricella LA
Ann Thorac Surg 2011 Aug;92(2):556-60; discussion 560-1. doi: 10.1016/j.athoracsur.2011.04.003. PMID: 21801912
Renal dysfunction and fluid and electrolyte disturbances.
Hashem R, Weissman C
Curr Opin Crit Care 2011 Aug;17(4):390-5. doi: 10.1097/MCC.0b013e328348bef5. PMID: 21716110
Three-dimensional contrast-enhanced MR angiography of aortic dissection: a pictorial essay.
Liu Q, Lu JP, Wang F, Wang L, Tian JM
Radiographics 2007 Sep-Oct;27(5):1311-21. doi: 10.1148/rg.275065737. PMID: 17848693
Suspected aortic dissection and other aortic disorders: multi-detector row CT in 373 cases in the emergency setting.
Hayter RG, Rhea JT, Small A, Tafazoli FS, Novelline RA
Radiology 2006 Mar;238(3):841-52. Epub 2006 Feb 1 doi: 10.1148/radiol.2383041528. PMID: 16452396

Clinical prediction guides

Abdominal aortic intimal flap motion characterization in acute aortic dissection: assessed with retrospective ECG-gated thoracoabdominal aorta dual-source CT angiography.
Yang S, Li X, Chao B, Wu L, Cheng Z, Duan Y, Wu D, Zhan Y, Chen J, Liu B, Ji X, Nie P, Wang X
PLoS One 2014;9(2):e87664. Epub 2014 Feb 4 doi: 10.1371/journal.pone.0087664. PMID: 24503676Free PMC Article
Valve-sparing aortic root replacement in Loeys-Dietz syndrome.
Patel ND, Arnaoutakis GJ, George TJ, Allen JG, Alejo DE, Dietz HC, Cameron DE, Vricella LA
Ann Thorac Surg 2011 Aug;92(2):556-60; discussion 560-1. doi: 10.1016/j.athoracsur.2011.04.003. PMID: 21801912
Different clinical pictures of penetrating ulcer of the aorta, an underrated aortic disease.
Anselmi A, Luciani N, Perri G, Palladino M, Tsiopoulos V
J Cardiovasc Med (Hagerstown) 2010 Nov;11(11):815-9. doi: 10.2459/JCM.0b013e32833cdb96. PMID: 20639766
Suspected aortic dissection and other aortic disorders: multi-detector row CT in 373 cases in the emergency setting.
Hayter RG, Rhea JT, Small A, Tafazoli FS, Novelline RA
Radiology 2006 Mar;238(3):841-52. Epub 2006 Feb 1 doi: 10.1148/radiol.2383041528. PMID: 16452396

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