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Extraosseous osteosarcoma

MedGen UID:
163186
•Concept ID:
C0855052
•
Neoplastic Process
Synonyms: Extraosseous Osteosarcoma; extraosseous osteosarcoma; Extraskeletal Osteogenic Sarcoma; extraskeletal osteogenic sarcoma; Extraskeletal osteosarcoma; Extraskeletal Osteosarcoma; extraskeletal osteosarcoma; osteosarcoma, extraskeletal, malignant; Soft Tissue Osteosarcoma; soft tissue osteosarcoma
SNOMED CT: Extraskeletal osteosarcoma (404077005)
 
Monarch Initiative: MONDO:0002621

Definition

An osteosarcoma arising from the soft tissue. [from NCI]

Professional guidelines

PubMed

Imaging diagnosis and differential diagnosis of extraskeletal osteosarcoma.
Wang XC, Zhang L, Lin JB, Huang XY, Liang JH, Zhong JP, Peng JD, Zhong JY
BMC Cancer 2024 Jan 2;24(1):11. doi: 10.1186/s12885-023-11731-3. PMID: 38166700Free PMC Article
Practical Management of Adult Ultra-Rare Primary Retroperitoneal Soft Tissue Sarcoma: A Focus on Perivascular Epithelioid Tumours and Extraosseous Ewing Sarcoma.
Apte SS, Mor E, Mitchell C, Gyorki DE
Curr Oncol 2023 Jun 21;30(7):5953-5972. doi: 10.3390/curroncol30070445. PMID: 37504306Free PMC Article
Extraosseous osteosarcoma: response to treatment and long-term outcome.
Ahmad SA, Patel SR, Ballo MT, Baker TP, Yasko AW, Wang X, Feig BW, Hunt KK, Lin PP, Weber KL, Chen LL, Zagars GK, Pollock RE, Benjamin RS, Pisters PW
J Clin Oncol 2002 Jan 15;20(2):521-7. doi: 10.1200/JCO.2002.20.2.521. PMID: 11786582

Recent clinical studies

Etiology

Imaging diagnosis and differential diagnosis of extraskeletal osteosarcoma.
Wang XC, Zhang L, Lin JB, Huang XY, Liang JH, Zhong JP, Peng JD, Zhong JY
BMC Cancer 2024 Jan 2;24(1):11. doi: 10.1186/s12885-023-11731-3. PMID: 38166700Free PMC Article
Survival Differences of Patients with Resected Extraskeletal Osteosarcoma Receiving Two Different (Neo)Adjuvant Chemotherapy Regimens: A Systematic Review and Meta-analysis.
Campos F, Téres R, Sebio A, Bettim BB, Martinez-Trufero J
Clin Oncol (R Coll Radiol) 2023 Dec;35(12):e720-e727. Epub 2023 Sep 22 doi: 10.1016/j.clon.2023.09.009. PMID: 37777356
Intraperitoneal extraosseous osteosarcoma: a case report and literatures review.
Wang T, Liao S, Ding X, Anil KC, Huang Q, Lin C, Mo J, Tang H, Liu Y
BMC Musculoskelet Disord 2020 Jul 11;21(1):452. doi: 10.1186/s12891-020-03429-5. PMID: 32653041Free PMC Article
Should High-grade Extraosseous Osteosarcoma Be Treated With Multimodality Therapy Like Other Soft Tissue Sarcomas?
Fan Z, Patel S, Lewis VO, Guadagnolo BA, Lin PP
Clin Orthop Relat Res 2015 Nov;473(11):3604-11. Epub 2015 Jul 22 doi: 10.1007/s11999-015-4463-y. PMID: 26197952Free PMC Article
Extraosseous osteosarcoma: response to treatment and long-term outcome.
Ahmad SA, Patel SR, Ballo MT, Baker TP, Yasko AW, Wang X, Feig BW, Hunt KK, Lin PP, Weber KL, Chen LL, Zagars GK, Pollock RE, Benjamin RS, Pisters PW
J Clin Oncol 2002 Jan 15;20(2):521-7. doi: 10.1200/JCO.2002.20.2.521. PMID: 11786582

Diagnosis

Imaging diagnosis and differential diagnosis of extraskeletal osteosarcoma.
Wang XC, Zhang L, Lin JB, Huang XY, Liang JH, Zhong JP, Peng JD, Zhong JY
BMC Cancer 2024 Jan 2;24(1):11. doi: 10.1186/s12885-023-11731-3. PMID: 38166700Free PMC Article
Anterior abdominal wall extraosseous osteosarcoma, occurring 40 years after para-aortic irradiation.
Furrukh M, Qureshi A, Mamoon N, Fatima M
BMJ Case Rep 2017 Jun 22;2017 doi: 10.1136/bcr-2017-219722. PMID: 28645924Free PMC Article
Combined replacement of infrarenal aorta and inferior vena cava after en bloc resection of retroperitoneal extraosseous osteosarcoma.
Schneider JR, Sener SF, Barrera E Jr
J Vasc Surg 2008 Aug;48(2):478-9. doi: 10.1016/j.jvs.2007.12.052. PMID: 18644493
Primary osteosarcoma of the thyroid gland.
Nitzsche EU, Seeger LL, Klosa B, Freudenberg N, Moser EA
J Nucl Med 1992 Jul;33(7):1399-401. PMID: 1319482
Extraosseous osteosarcoma: case report and approach to therapy.
Lewis RJ, Lotz MJ, Beazley RM
Am Surg 1974 Oct;40(10):597-600. PMID: 4528559

Therapy

Survival Differences of Patients with Resected Extraskeletal Osteosarcoma Receiving Two Different (Neo)Adjuvant Chemotherapy Regimens: A Systematic Review and Meta-analysis.
Campos F, Téres R, Sebio A, Bettim BB, Martinez-Trufero J
Clin Oncol (R Coll Radiol) 2023 Dec;35(12):e720-e727. Epub 2023 Sep 22 doi: 10.1016/j.clon.2023.09.009. PMID: 37777356
Anterior abdominal wall extraosseous osteosarcoma, occurring 40 years after para-aortic irradiation.
Furrukh M, Qureshi A, Mamoon N, Fatima M
BMJ Case Rep 2017 Jun 22;2017 doi: 10.1136/bcr-2017-219722. PMID: 28645924Free PMC Article
Should High-grade Extraosseous Osteosarcoma Be Treated With Multimodality Therapy Like Other Soft Tissue Sarcomas?
Fan Z, Patel S, Lewis VO, Guadagnolo BA, Lin PP
Clin Orthop Relat Res 2015 Nov;473(11):3604-11. Epub 2015 Jul 22 doi: 10.1007/s11999-015-4463-y. PMID: 26197952Free PMC Article
A chemosensitive pediatric extraosseous osteosarcoma: case report and review of the literature.
Wodowski K, Hill DA, Pappo AS, Shochat SJ, Kun LE, Spunt SL
J Pediatr Hematol Oncol 2003 Jan;25(1):73-7. doi: 10.1097/00043426-200301000-00015. PMID: 12544778
Extraosseous osteosarcoma: response to treatment and long-term outcome.
Ahmad SA, Patel SR, Ballo MT, Baker TP, Yasko AW, Wang X, Feig BW, Hunt KK, Lin PP, Weber KL, Chen LL, Zagars GK, Pollock RE, Benjamin RS, Pisters PW
J Clin Oncol 2002 Jan 15;20(2):521-7. doi: 10.1200/JCO.2002.20.2.521. PMID: 11786582

Prognosis

Anterior abdominal wall extraosseous osteosarcoma, occurring 40 years after para-aortic irradiation.
Furrukh M, Qureshi A, Mamoon N, Fatima M
BMJ Case Rep 2017 Jun 22;2017 doi: 10.1136/bcr-2017-219722. PMID: 28645924Free PMC Article
Combined replacement of infrarenal aorta and inferior vena cava after en bloc resection of retroperitoneal extraosseous osteosarcoma.
Schneider JR, Sener SF, Barrera E Jr
J Vasc Surg 2008 Aug;48(2):478-9. doi: 10.1016/j.jvs.2007.12.052. PMID: 18644493
Extraosseous osteosarcoma of the penis.
Fraser G, Harnett AN, Reid R
Clin Oncol (R Coll Radiol) 2000;12(4):238-9. doi: 10.1053/clon.2000.9163. PMID: 11005691
Heterotopic mesenteric ossification ('intraabdominal myositis ossificans'): report of five cases.
Wilson JD, Montague CJ, Salcuni P, Bordi C, Rosai J
Am J Surg Pathol 1999 Dec;23(12):1464-70. doi: 10.1097/00000478-199912000-00003. PMID: 10584699
Extraosseous osteosarcoma: case report and approach to therapy.
Lewis RJ, Lotz MJ, Beazley RM
Am Surg 1974 Oct;40(10):597-600. PMID: 4528559

Clinical prediction guides

Should High-grade Extraosseous Osteosarcoma Be Treated With Multimodality Therapy Like Other Soft Tissue Sarcomas?
Fan Z, Patel S, Lewis VO, Guadagnolo BA, Lin PP
Clin Orthop Relat Res 2015 Nov;473(11):3604-11. Epub 2015 Jul 22 doi: 10.1007/s11999-015-4463-y. PMID: 26197952Free PMC Article
Phase II trial of pegylated-liposomal doxorubicin (Doxil) in sarcoma.
Skubitz KM
Cancer Invest 2003 Apr;21(2):167-76. doi: 10.1081/cnv-120016412. PMID: 12743981

Recent systematic reviews

Survival Differences of Patients with Resected Extraskeletal Osteosarcoma Receiving Two Different (Neo)Adjuvant Chemotherapy Regimens: A Systematic Review and Meta-analysis.
Campos F, Téres R, Sebio A, Bettim BB, Martinez-Trufero J
Clin Oncol (R Coll Radiol) 2023 Dec;35(12):e720-e727. Epub 2023 Sep 22 doi: 10.1016/j.clon.2023.09.009. PMID: 37777356

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