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Adenomatous polyp of colon

MedGen UID:
163407
•Concept ID:
C0850572
•
Neoplastic Process
Synonym: Adenomatous colon polyp
SNOMED CT: Adenomatous polyp of colon (428054006)
 
Monarch Initiative: MONDO:0006498

Definition

A polypoid adenoma that arises from and protrudes into the lumen of the colon. Epithelial dysplasia is always present. According to the architectural pattern it is classified as tubular, tubulovillous, or villous. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • Adenomatous polyp of colon

Professional guidelines

PubMed

Colorectal polypectomy and endoscopic mucosal resection: European Society of Gastrointestinal Endoscopy (ESGE) Guideline - Update 2024.
Ferlitsch M, Hassan C, Bisschops R, Bhandari P, Dinis-Ribeiro M, Risio M, Paspatis GA, Moss A, Libânio D, Lorenzo-Zúñiga V, Voiosu AM, Rutter MD, Pellisé M, Moons LMG, Probst A, Awadie H, Amato A, Takeuchi Y, Repici A, Rahmi G, Koecklin HU, Albéniz E, Rockenbauer LM, Waldmann E, Messmann H, Triantafyllou K, Jover R, Gralnek IM, Dekker E, Bourke MJ
Endoscopy 2024 Jul;56(7):516-545. Epub 2024 Apr 26 doi: 10.1055/a-2304-3219. PMID: 38670139
Terminology, Molecular Features, Epidemiology, and Management of Serrated Colorectal Neoplasia.
Crockett SD, Nagtegaal ID
Gastroenterology 2019 Oct;157(4):949-966.e4. Epub 2019 Jul 16 doi: 10.1053/j.gastro.2019.06.041. PMID: 31323292
Pathophysiology, clinical presentation, and management of colon cancer.
Cappell MS
Gastroenterol Clin North Am 2008 Mar;37(1):1-24, v. doi: 10.1016/j.gtc.2007.12.002. PMID: 18313537

Recent clinical studies

Etiology

Colorectal polypectomy and endoscopic mucosal resection: European Society of Gastrointestinal Endoscopy (ESGE) Guideline - Update 2024.
Ferlitsch M, Hassan C, Bisschops R, Bhandari P, Dinis-Ribeiro M, Risio M, Paspatis GA, Moss A, Libânio D, Lorenzo-Zúñiga V, Voiosu AM, Rutter MD, Pellisé M, Moons LMG, Probst A, Awadie H, Amato A, Takeuchi Y, Repici A, Rahmi G, Koecklin HU, Albéniz E, Rockenbauer LM, Waldmann E, Messmann H, Triantafyllou K, Jover R, Gralnek IM, Dekker E, Bourke MJ
Endoscopy 2024 Jul;56(7):516-545. Epub 2024 Apr 26 doi: 10.1055/a-2304-3219. PMID: 38670139
Gastritis, Gastric Polyps and Gastric Cancer.
Waldum H, Fossmark R
Int J Mol Sci 2021 Jun 18;22(12) doi: 10.3390/ijms22126548. PMID: 34207192Free PMC Article
Terminology, Molecular Features, Epidemiology, and Management of Serrated Colorectal Neoplasia.
Crockett SD, Nagtegaal ID
Gastroenterology 2019 Oct;157(4):949-966.e4. Epub 2019 Jul 16 doi: 10.1053/j.gastro.2019.06.041. PMID: 31323292
Colorectal polypectomy and endoscopic mucosal resection (EMR): European Society of Gastrointestinal Endoscopy (ESGE) Clinical Guideline.
Ferlitsch M, Moss A, Hassan C, Bhandari P, Dumonceau JM, Paspatis G, Jover R, Langner C, Bronzwaer M, Nalankilli K, Fockens P, Hazzan R, Gralnek IM, Gschwantler M, Waldmann E, Jeschek P, Penz D, Heresbach D, Moons L, Lemmers A, Paraskeva K, Pohl J, Ponchon T, Regula J, Repici A, Rutter MD, Burgess NG, Bourke MJ
Endoscopy 2017 Mar;49(3):270-297. Epub 2017 Feb 17 doi: 10.1055/s-0043-102569. PMID: 28212588
Gastrointestinal adenomatous polyps.
Itzkowitz SH
Semin Gastrointest Dis 1996 Apr;7(2):105-16. PMID: 8705258

Diagnosis

Colorectal polypectomy and endoscopic mucosal resection (EMR): European Society of Gastrointestinal Endoscopy (ESGE) Clinical Guideline.
Ferlitsch M, Moss A, Hassan C, Bhandari P, Dumonceau JM, Paspatis G, Jover R, Langner C, Bronzwaer M, Nalankilli K, Fockens P, Hazzan R, Gralnek IM, Gschwantler M, Waldmann E, Jeschek P, Penz D, Heresbach D, Moons L, Lemmers A, Paraskeva K, Pohl J, Ponchon T, Regula J, Repici A, Rutter MD, Burgess NG, Bourke MJ
Endoscopy 2017 Mar;49(3):270-297. Epub 2017 Feb 17 doi: 10.1055/s-0043-102569. PMID: 28212588
Obesity and Colorectal Cancer.
Jochem C, Leitzmann M
Recent Results Cancer Res 2016;208:17-41. doi: 10.1007/978-3-319-42542-9_2. PMID: 27909900
Interval colorectal carcinoma: An unsolved debate.
Benedict M, Galvao Neto A, Zhang X
World J Gastroenterol 2015 Dec 7;21(45):12735-41. doi: 10.3748/wjg.v21.i45.12735. PMID: 26668498Free PMC Article
Traditional serrated adenoma: an update.
Bettington ML, Chetty R
Hum Pathol 2015 Jul;46(7):933-8. Epub 2015 Apr 20 doi: 10.1016/j.humpath.2015.04.002. PMID: 26001333
Familial adenomatous polyposis.
Lal G, Gallinger S
Semin Surg Oncol 2000 Jun;18(4):314-23. doi: 10.1002/(sici)1098-2388(200006)18:4<314::aid-ssu6>3.0.co;2-9. PMID: 10805953

Therapy

Dietary Inflammatory Potential and the Risk of Serrated and Adenomatous Colorectal Polyps.
Sung LB, Coleman HG, Shivappa N, Hébert JR, Murff HJ, Milne GL, Ness RM, Smalley WE, Zheng W, Shrubsole MJ
Nutr Cancer 2023;75(10):1900-1910. Epub 2023 Nov 30 doi: 10.1080/01635581.2023.2261651. PMID: 37791878Free PMC Article
Artificial intelligence-assisted optical diagnosis for the resect-and-discard strategy in clinical practice: the Artificial intelligence BLI Characterization (ABC) study.
Rondonotti E, Hassan C, Tamanini G, Antonelli G, Andrisani G, Leonetti G, Paggi S, Amato A, Scardino G, Di Paolo D, Mandelli G, Lenoci N, Terreni N, Andrealli A, Maselli R, Spadaccini M, Galtieri PA, Correale L, Repici A, Di Matteo FM, Ambrosiani L, Filippi E, Sharma P, Radaelli F
Endoscopy 2023 Jan;55(1):14-22. Epub 2022 May 13 doi: 10.1055/a-1852-0330. PMID: 35562098
Molecular mechanism of adenomatous polyposis coli-induced blockade of base excision repair pathway in colorectal carcinogenesis.
Narayan S, Sharma R
Life Sci 2015 Oct 15;139:145-52. Epub 2015 Sep 1 doi: 10.1016/j.lfs.2015.08.019. PMID: 26334567Free PMC Article
Management of malignant colon polyps: current status and controversies.
Aarons CB, Shanmugan S, Bleier JI
World J Gastroenterol 2014 Nov 21;20(43):16178-83. doi: 10.3748/wjg.v20.i43.16178. PMID: 25473171Free PMC Article
Colorectal cancer prevention.
Hawk ET, Levin B
J Clin Oncol 2005 Jan 10;23(2):378-91. doi: 10.1200/JCO.2005.08.097. PMID: 15637400

Prognosis

Terminology, Molecular Features, Epidemiology, and Management of Serrated Colorectal Neoplasia.
Crockett SD, Nagtegaal ID
Gastroenterology 2019 Oct;157(4):949-966.e4. Epub 2019 Jul 16 doi: 10.1053/j.gastro.2019.06.041. PMID: 31323292
Heart Failure Stimulates Tumor Growth by Circulating Factors.
Meijers WC, Maglione M, Bakker SJL, Oberhuber R, Kieneker LM, de Jong S, Haubner BJ, Nagengast WB, Lyon AR, van der Vegt B, van Veldhuisen DJ, Westenbrink BD, van der Meer P, Silljé HHW, de Boer RA
Circulation 2018 Aug 14;138(7):678-691. doi: 10.1161/CIRCULATIONAHA.117.030816. PMID: 29459363
Interval colorectal carcinoma: An unsolved debate.
Benedict M, Galvao Neto A, Zhang X
World J Gastroenterol 2015 Dec 7;21(45):12735-41. doi: 10.3748/wjg.v21.i45.12735. PMID: 26668498Free PMC Article
Colonoscopic polypectomy and long-term prevention of colorectal-cancer deaths.
Zauber AG, Winawer SJ, O'Brien MJ, Lansdorp-Vogelaar I, van Ballegooijen M, Hankey BF, Shi W, Bond JH, Schapiro M, Panish JF, Stewart ET, Waye JD
N Engl J Med 2012 Feb 23;366(8):687-96. doi: 10.1056/NEJMoa1100370. PMID: 22356322Free PMC Article
Colonic polyps.
Ackroyd FW, Hedberg SE
Annu Rev Med 1985;36:619-25. doi: 10.1146/annurev.me.36.020185.003155. PMID: 3994327

Clinical prediction guides

Heart Failure Stimulates Tumor Growth by Circulating Factors.
Meijers WC, Maglione M, Bakker SJL, Oberhuber R, Kieneker LM, de Jong S, Haubner BJ, Nagengast WB, Lyon AR, van der Vegt B, van Veldhuisen DJ, Westenbrink BD, van der Meer P, Silljé HHW, de Boer RA
Circulation 2018 Aug 14;138(7):678-691. doi: 10.1161/CIRCULATIONAHA.117.030816. PMID: 29459363
Interval colorectal carcinoma: An unsolved debate.
Benedict M, Galvao Neto A, Zhang X
World J Gastroenterol 2015 Dec 7;21(45):12735-41. doi: 10.3748/wjg.v21.i45.12735. PMID: 26668498Free PMC Article
Traditional serrated adenoma: an update.
Bettington ML, Chetty R
Hum Pathol 2015 Jul;46(7):933-8. Epub 2015 Apr 20 doi: 10.1016/j.humpath.2015.04.002. PMID: 26001333
Colonoscopic polypectomy and long-term prevention of colorectal-cancer deaths.
Zauber AG, Winawer SJ, O'Brien MJ, Lansdorp-Vogelaar I, van Ballegooijen M, Hankey BF, Shi W, Bond JH, Schapiro M, Panish JF, Stewart ET, Waye JD
N Engl J Med 2012 Feb 23;366(8):687-96. doi: 10.1056/NEJMoa1100370. PMID: 22356322Free PMC Article
Familial adenomatous polyposis.
Lal G, Gallinger S
Semin Surg Oncol 2000 Jun;18(4):314-23. doi: 10.1002/(sici)1098-2388(200006)18:4<314::aid-ssu6>3.0.co;2-9. PMID: 10805953

Recent systematic reviews

Diagnosis and Management of Cuffitis: A Systematic Review.
Hembree AE, Scherl E
Dis Colon Rectum 2022 Dec 1;65(S1):S85-S91. Epub 2022 Aug 25 doi: 10.1097/DCR.0000000000002593. PMID: 36399769
Computer-Aided Diagnosis of Diminutive Colorectal Polyps in Endoscopic Images: Systematic Review and Meta-analysis of Diagnostic Test Accuracy.
Bang CS, Lee JJ, Baik GH
J Med Internet Res 2021 Aug 25;23(8):e29682. doi: 10.2196/29682. PMID: 34432643Free PMC Article
Complications and functional outcomes after ileo-anal pouch excision-a systematic review of 14 retrospective observational studies.
MacDonald S, Au S, Thornton M, Macdonald A
Int J Colorectal Dis 2021 Apr;36(4):677-687. Epub 2021 Jan 20 doi: 10.1007/s00384-021-03838-5. PMID: 33471205
Association between breast cancer and the risk of colorectal cancer.
Lai JH, Park G, Gerson LB
Gastrointest Endosc 2017 Sep;86(3):429-441.e1. Epub 2017 Apr 20 doi: 10.1016/j.gie.2017.04.008. PMID: 28433614
Colonic manifestations of PTEN hamartoma tumor syndrome: case series and systematic review.
Stanich PP, Pilarski R, Rock J, Frankel WL, El-Dika S, Meyer MM
World J Gastroenterol 2014 Feb 21;20(7):1833-8. doi: 10.3748/wjg.v20.i7.1833. PMID: 24587660Free PMC Article

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