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Colon adenoma

MedGen UID:
1639098
•Concept ID:
C4551463
•
Neoplastic Process
Synonym: Colonic adenomas
 
Monarch Initiative: MONDO:0000527

Definition

An adenoma that arises from the colon. The group of colonic adenomas includes tubular, villous, and tubulovillous adenomas, traditional serrated adenomas, sessile serrated adenomas/polyps, and familial adenomatous polyposis. [from NCI]

Professional guidelines

PubMed

Effect of Insulin and Metformin Combination Treatment on Colon Adenoma and Advanced Adenoma Among DM II.
Jain D, Chhoda A, Uribe J
J Gastrointest Cancer 2016 Dec;47(4):404-408. doi: 10.1007/s12029-016-9842-4. PMID: 27256336
Reduction of Murine Colon Tumorigenesis Driven by Enterotoxigenic Bacteroides fragilis Using Cefoxitin Treatment.
DeStefano Shields CE, Van Meerbeke SW, Housseau F, Wang H, Huso DL, Casero RA Jr, O'Hagan HM, Sears CL
J Infect Dis 2016 Jul 1;214(1):122-9. Epub 2016 Feb 21 doi: 10.1093/infdis/jiw069. PMID: 26908749Free PMC Article
Celecoxib and tauro-ursodeoxycholic acid co-treatment inhibits cell growth in familial adenomatous polyposis derived LT97 colon adenoma cells.
van Heumen BW, Roelofs HM, Te Morsche RH, Marian B, Nagengast FM, Peters WH
Exp Cell Res 2012 Apr 15;318(7):819-27. Epub 2012 Feb 14 doi: 10.1016/j.yexcr.2012.02.004. PMID: 22366264

Recent clinical studies

Etiology

Randomized, Double-Blind, Placebo-Controlled Trial of MUC1 Peptide Vaccine for Prevention of Recurrent Colorectal Adenoma.
Schoen RE, Boardman LA, Cruz-Correa M, Bansal A, Kastenberg D, Hur C, Dzubinski L, Kaufman SF, Rodriguez LM, Richmond E, Umar A, Szabo E, Salazar A, McKolanis J, Beatty P, Pai RK, Singhi AD, Jacqueline CM, Bao R, Diergaarde B, McMurray RP, Strand C, Foster NR, Zahrieh DM, Limburg PJ, Finn OJ
Clin Cancer Res 2023 May 1;29(9):1678-1688. doi: 10.1158/1078-0432.CCR-22-3168. PMID: 36892581Free PMC Article
Obesity, diabetes and the risk of colorectal adenoma and cancer.
Soltani G, Poursheikhani A, Yassi M, Hayatbakhsh A, Kerachian M, Kerachian MA
BMC Endocr Disord 2019 Oct 29;19(1):113. doi: 10.1186/s12902-019-0444-6. PMID: 31664994Free PMC Article
Patients with Non-Hodgkin's Lymphoma Are at Risk of Adenomatous Colon Polyps.
Abu-Sbeih H, Chen E, Ahmed O, Mallepally N, Lum P, Qiao W, Lee HJ, Bresalier R, Wang LS, Weston B, Raju GS, Wang Y
Dig Dis Sci 2019 Oct;64(10):2965-2971. Epub 2019 May 3 doi: 10.1007/s10620-019-05629-z. PMID: 31053975
Pharmacological and dietary factors in prevention of colorectal cancer.
Waluga M, Zorniak M, Fichna J, Kukla M, Hartleb M
J Physiol Pharmacol 2018 Jun;69(3) Epub 2018 Aug 22 doi: 10.26402/jpp.2018.3.02. PMID: 30149368
Long-term use of progestogens: colon adenoma and colon carcinoma.
Schindler AE
Gynecol Endocrinol 2007 Oct;23 Suppl 1:42-4. doi: 10.1080/09513590701584899. PMID: 17943538

Diagnosis

Randomized, Double-Blind, Placebo-Controlled Trial of MUC1 Peptide Vaccine for Prevention of Recurrent Colorectal Adenoma.
Schoen RE, Boardman LA, Cruz-Correa M, Bansal A, Kastenberg D, Hur C, Dzubinski L, Kaufman SF, Rodriguez LM, Richmond E, Umar A, Szabo E, Salazar A, McKolanis J, Beatty P, Pai RK, Singhi AD, Jacqueline CM, Bao R, Diergaarde B, McMurray RP, Strand C, Foster NR, Zahrieh DM, Limburg PJ, Finn OJ
Clin Cancer Res 2023 May 1;29(9):1678-1688. doi: 10.1158/1078-0432.CCR-22-3168. PMID: 36892581Free PMC Article
Insulin levels are associated with risk of colon adenoma and not nonadenomatous polyps: A retrospective, hospital-based study.
Shin HS, Cho YJ
Medicine (Baltimore) 2022 Aug 26;101(34):e30200. doi: 10.1097/MD.0000000000030200. PMID: 36042665Free PMC Article
Obesity, diabetes and the risk of colorectal adenoma and cancer.
Soltani G, Poursheikhani A, Yassi M, Hayatbakhsh A, Kerachian M, Kerachian MA
BMC Endocr Disord 2019 Oct 29;19(1):113. doi: 10.1186/s12902-019-0444-6. PMID: 31664994Free PMC Article
Quantitative spectroscopic imaging for non-invasive early cancer detection.
Yu CC, Lau C, O'Donoghue G, Mirkovic J, McGee S, Galindo L, Elackattu A, Stier E, Grillone G, Badizadegan K, Dasari RR, Feld MS
Opt Express 2008 Sep 29;16(20):16227-39. doi: 10.1364/oe.16.016227. PMID: 18825262Free PMC Article
Absence of cytomegalovirus, Epstein-Barr virus, and papillomavirus DNA from adenoma and adenocarcinoma of the colon.
Boguszaková L, Hirsch I, Brichácek B, Faltýn J, Fric P, Dvoráková H, Vonka V
Acta Virol 1988 Jul;32(4):303-8. PMID: 2903634

Therapy

Randomized, Double-Blind, Placebo-Controlled Trial of MUC1 Peptide Vaccine for Prevention of Recurrent Colorectal Adenoma.
Schoen RE, Boardman LA, Cruz-Correa M, Bansal A, Kastenberg D, Hur C, Dzubinski L, Kaufman SF, Rodriguez LM, Richmond E, Umar A, Szabo E, Salazar A, McKolanis J, Beatty P, Pai RK, Singhi AD, Jacqueline CM, Bao R, Diergaarde B, McMurray RP, Strand C, Foster NR, Zahrieh DM, Limburg PJ, Finn OJ
Clin Cancer Res 2023 May 1;29(9):1678-1688. doi: 10.1158/1078-0432.CCR-22-3168. PMID: 36892581Free PMC Article
Insulin levels are associated with risk of colon adenoma and not nonadenomatous polyps: A retrospective, hospital-based study.
Shin HS, Cho YJ
Medicine (Baltimore) 2022 Aug 26;101(34):e30200. doi: 10.1097/MD.0000000000030200. PMID: 36042665Free PMC Article
Pharmacological and dietary factors in prevention of colorectal cancer.
Waluga M, Zorniak M, Fichna J, Kukla M, Hartleb M
J Physiol Pharmacol 2018 Jun;69(3) Epub 2018 Aug 22 doi: 10.26402/jpp.2018.3.02. PMID: 30149368
Endoscopic management of mucosal lesions in the gastrointestinal tract.
Chen WC, Wallace MB
Expert Rev Gastroenterol Hepatol 2016;10(4):481-95. Epub 2015 Dec 11 doi: 10.1586/17474124.2016.1122520. PMID: 26581857
Long-term use of progestogens: colon adenoma and colon carcinoma.
Schindler AE
Gynecol Endocrinol 2007 Oct;23 Suppl 1:42-4. doi: 10.1080/09513590701584899. PMID: 17943538

Prognosis

GUCA2A dysregulation as a promising biomarker for accurate diagnosis and prognosis of colorectal cancer.
Jalali P, Aliyari S, Etesami M, Saeedi Niasar M, Taher S, Kavousi K, Nazemalhosseini Mojarad E, Salehi Z
Clin Exp Med 2024 Nov 1;24(1):251. doi: 10.1007/s10238-024-01512-y. PMID: 39485546Free PMC Article
Integrated multi-omic analyses provide insight into colon adenoma susceptibility modulation by the gut microbiota.
Busi SB, Lei Z, Sumner LW, Amos-Landgraf JM
mSystems 2023 Aug 31;8(4):e0015123. Epub 2023 Jul 17 doi: 10.1128/msystems.00151-23. PMID: 37458451Free PMC Article
Obesity, diabetes and the risk of colorectal adenoma and cancer.
Soltani G, Poursheikhani A, Yassi M, Hayatbakhsh A, Kerachian M, Kerachian MA
BMC Endocr Disord 2019 Oct 29;19(1):113. doi: 10.1186/s12902-019-0444-6. PMID: 31664994Free PMC Article
Patients with Non-Hodgkin's Lymphoma Are at Risk of Adenomatous Colon Polyps.
Abu-Sbeih H, Chen E, Ahmed O, Mallepally N, Lum P, Qiao W, Lee HJ, Bresalier R, Wang LS, Weston B, Raju GS, Wang Y
Dig Dis Sci 2019 Oct;64(10):2965-2971. Epub 2019 May 3 doi: 10.1007/s10620-019-05629-z. PMID: 31053975
Loss of 1p36, gain of 8q24, and loss of 9q34 are associated with stroma percentage of colorectal cancer.
Fijneman RJ, Carvalho B, Postma C, Mongera S, van Hinsbergh VW, Meijer GA
Cancer Lett 2007 Dec 18;258(2):223-9. Epub 2007 Oct 30 doi: 10.1016/j.canlet.2007.09.013. PMID: 17977645

Clinical prediction guides

Integrated multi-omic analyses provide insight into colon adenoma susceptibility modulation by the gut microbiota.
Busi SB, Lei Z, Sumner LW, Amos-Landgraf JM
mSystems 2023 Aug 31;8(4):e0015123. Epub 2023 Jul 17 doi: 10.1128/msystems.00151-23. PMID: 37458451Free PMC Article
Randomized, Double-Blind, Placebo-Controlled Trial of MUC1 Peptide Vaccine for Prevention of Recurrent Colorectal Adenoma.
Schoen RE, Boardman LA, Cruz-Correa M, Bansal A, Kastenberg D, Hur C, Dzubinski L, Kaufman SF, Rodriguez LM, Richmond E, Umar A, Szabo E, Salazar A, McKolanis J, Beatty P, Pai RK, Singhi AD, Jacqueline CM, Bao R, Diergaarde B, McMurray RP, Strand C, Foster NR, Zahrieh DM, Limburg PJ, Finn OJ
Clin Cancer Res 2023 May 1;29(9):1678-1688. doi: 10.1158/1078-0432.CCR-22-3168. PMID: 36892581Free PMC Article
Comparing right colon adenoma detection rate during water exchange and air insufflation: a double-blind randomized controlled trial.
Tseng CW, Hsieh YH, Koo M, Leung FW
Tech Coloproctol 2022 Jan;26(1):35-44. Epub 2021 Oct 27 doi: 10.1007/s10151-021-02537-1. PMID: 34705136
Obesity, diabetes and the risk of colorectal adenoma and cancer.
Soltani G, Poursheikhani A, Yassi M, Hayatbakhsh A, Kerachian M, Kerachian MA
BMC Endocr Disord 2019 Oct 29;19(1):113. doi: 10.1186/s12902-019-0444-6. PMID: 31664994Free PMC Article
Cell-surface markers for colon adenoma and adenocarcinoma.
Sewda K, Coppola D, Enkemann S, Yue B, Kim J, Lopez AS, Wojtkowiak JW, Stark VE, Morse B, Shibata D, Vignesh S, Morse DL
Oncotarget 2016 Apr 5;7(14):17773-89. doi: 10.18632/oncotarget.7402. PMID: 26894861Free PMC Article

Recent systematic reviews

Endocuff-assisted versus Cap-assisted Colonoscopy in Increasing Adenoma Detection Rate. A Meta-analysis.
Facciorusso A, Buccino VR, Sacco R
J Gastrointestin Liver Dis 2020 Sep 9;29(3):415-420. doi: 10.15403/jgld-1239. PMID: 32830810
Compared Abilities of Endoscopic Techniques to Increase Colon Adenoma Detection Rates: A Network Meta-analysis.
Facciorusso A, Triantafyllou K, Murad MH, Prokop LJ, Tziatzios G, Muscatiello N, Singh S
Clin Gastroenterol Hepatol 2019 Nov;17(12):2439-2454.e25. Epub 2018 Dec 6 doi: 10.1016/j.cgh.2018.11.058. PMID: 30529731
The benefit of adding oral simethicone in bowel preparation regimen for the detection of colon adenoma: A systematic review and meta-analysis.
Yeh JH, Hsu MH, Tseng CM, Chen TH, Huang RY, Lee CT, Lin CW, Wang WL
J Gastroenterol Hepatol 2019 May;34(5):830-836. Epub 2018 Nov 4 doi: 10.1111/jgh.14508. PMID: 30311262
Comparative Efficacy of Colonoscope Distal Attachment Devices in Increasing Rates of Adenoma Detection: A Network Meta-analysis.
Facciorusso A, Del Prete V, Buccino RV, Della Valle N, Nacchiero MC, Monica F, Cannizzaro R, Muscatiello N
Clin Gastroenterol Hepatol 2018 Aug;16(8):1209-1219.e9. Epub 2017 Nov 11 doi: 10.1016/j.cgh.2017.11.007. PMID: 29133257
Physical activity and risk of colon adenoma: a meta-analysis.
Wolin KY, Yan Y, Colditz GA
Br J Cancer 2011 Mar 1;104(5):882-5. Epub 2011 Feb 8 doi: 10.1038/sj.bjc.6606045. PMID: 21304525Free PMC Article

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