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Refractory Malignant Urinary System Neoplasm

MedGen UID:
1664391
•Concept ID:
C4725819
•
Neoplastic Process

Definition

Malignant urinary system neoplasm that is resistant to treatment. [from NCI]

Professional guidelines

PubMed

Research Progress on Mechanism and Management of Adverse Drug Reactions of Anlotinib.
Li S, Wang H
Drug Des Devel Ther 2023;17:3429-3437. Epub 2023 Nov 15 doi: 10.2147/DDDT.S426898. PMID: 38024530Free PMC Article
Lenvatinib dose, efficacy, and safety in the treatment of multiple malignancies.
Motzer RJ, Taylor MH, Evans TRJ, Okusaka T, Glen H, Lubiniecki GM, Dutcus C, Smith AD, Okpara CE, Hussein Z, Hayato S, Tamai T, Makker V
Expert Rev Anticancer Ther 2022 Apr;22(4):383-400. Epub 2022 Apr 7 doi: 10.1080/14737140.2022.2039123. PMID: 35260027Free PMC Article
Photodynamic Therapy in the Treatment of Bladder Cancer: Past Challenges and Current Innovations.
Railkar R, Agarwal PK
Eur Urol Focus 2018 Jul;4(4):509-511. Epub 2018 Aug 23 doi: 10.1016/j.euf.2018.08.005. PMID: 30145112

Recent clinical studies

Etiology

SMARCB1 regulates the hypoxic stress response in sickle cell trait.
Soeung M, Perelli L, Chen Z, Dondossola E, Ho IL, Carbone F, Zhang L, Khan H, Le CN, Zhu C, Peoples MD, Feng N, Jiang S, Zacharias NM, Minelli R, Shapiro DD, Deem AK, Gao S, Cheng EH, Lucchetti D, Walker CL, Carugo A, Giuliani V, Heffernan TP, Viale A, Tannir NM, Draetta GF, Msaouel P, Genovese G
Proc Natl Acad Sci U S A 2023 May 23;120(21):e2209639120. Epub 2023 May 15 doi: 10.1073/pnas.2209639120. PMID: 37186844Free PMC Article
Progress Update in Pediatric Renal Tumors.
Jain J, Sutton KS, Hong AL
Curr Oncol Rep 2021 Feb 16;23(3):33. doi: 10.1007/s11912-021-01016-y. PMID: 33591402
Role of immunotherapy in bladder cancer.
Rhea LP, Mendez-Marti S, Kim D, Aragon-Ching JB
Cancer Treat Res Commun 2021;26:100296. Epub 2020 Dec 24 doi: 10.1016/j.ctarc.2020.100296. PMID: 33421822
Pembrolizumab as Second-Line Therapy for Advanced Urothelial Carcinoma.
Bellmunt J, de Wit R, Vaughn DJ, Fradet Y, Lee JL, Fong L, Vogelzang NJ, Climent MA, Petrylak DP, Choueiri TK, Necchi A, Gerritsen W, Gurney H, Quinn DI, Culine S, Sternberg CN, Mai Y, Poehlein CH, Perini RF, Bajorin DF; KEYNOTE-045 Investigators
N Engl J Med 2017 Mar 16;376(11):1015-1026. Epub 2017 Feb 17 doi: 10.1056/NEJMoa1613683. PMID: 28212060Free PMC Article
Everolimus.
Houghton PJ
Clin Cancer Res 2010 Mar 1;16(5):1368-72. Epub 2010 Feb 23 doi: 10.1158/1078-0432.CCR-09-1314. PMID: 20179227Free PMC Article

Diagnosis

SMARCB1 regulates the hypoxic stress response in sickle cell trait.
Soeung M, Perelli L, Chen Z, Dondossola E, Ho IL, Carbone F, Zhang L, Khan H, Le CN, Zhu C, Peoples MD, Feng N, Jiang S, Zacharias NM, Minelli R, Shapiro DD, Deem AK, Gao S, Cheng EH, Lucchetti D, Walker CL, Carugo A, Giuliani V, Heffernan TP, Viale A, Tannir NM, Draetta GF, Msaouel P, Genovese G
Proc Natl Acad Sci U S A 2023 May 23;120(21):e2209639120. Epub 2023 May 15 doi: 10.1073/pnas.2209639120. PMID: 37186844Free PMC Article
Management of Urethral Hemangioma.
Alam R, Rostom M, Cohen AJ
Urology 2022 Feb;160:227. Epub 2021 Nov 13 doi: 10.1016/j.urology.2021.10.027. PMID: 34780843
Progress Update in Pediatric Renal Tumors.
Jain J, Sutton KS, Hong AL
Curr Oncol Rep 2021 Feb 16;23(3):33. doi: 10.1007/s11912-021-01016-y. PMID: 33591402
Renal cell carcinoma.
Hsieh JJ, Purdue MP, Signoretti S, Swanton C, Albiges L, Schmidinger M, Heng DY, Larkin J, Ficarra V
Nat Rev Dis Primers 2017 Mar 9;3:17009. doi: 10.1038/nrdp.2017.9. PMID: 28276433Free PMC Article
Everolimus.
Houghton PJ
Clin Cancer Res 2010 Mar 1;16(5):1368-72. Epub 2010 Feb 23 doi: 10.1158/1078-0432.CCR-09-1314. PMID: 20179227Free PMC Article

Therapy

Research Progress on Mechanism and Management of Adverse Drug Reactions of Anlotinib.
Li S, Wang H
Drug Des Devel Ther 2023;17:3429-3437. Epub 2023 Nov 15 doi: 10.2147/DDDT.S426898. PMID: 38024530Free PMC Article
CAR-T cells, from principle to clinical applications.
Bourbon E, Ghesquières H, Bachy E
Bull Cancer 2021 Oct;108(10S):S4-S17. doi: 10.1016/j.bulcan.2021.02.017. PMID: 34920806
Role of immunotherapy in bladder cancer.
Rhea LP, Mendez-Marti S, Kim D, Aragon-Ching JB
Cancer Treat Res Commun 2021;26:100296. Epub 2020 Dec 24 doi: 10.1016/j.ctarc.2020.100296. PMID: 33421822
Pembrolizumab as Second-Line Therapy for Advanced Urothelial Carcinoma.
Bellmunt J, de Wit R, Vaughn DJ, Fradet Y, Lee JL, Fong L, Vogelzang NJ, Climent MA, Petrylak DP, Choueiri TK, Necchi A, Gerritsen W, Gurney H, Quinn DI, Culine S, Sternberg CN, Mai Y, Poehlein CH, Perini RF, Bajorin DF; KEYNOTE-045 Investigators
N Engl J Med 2017 Mar 16;376(11):1015-1026. Epub 2017 Feb 17 doi: 10.1056/NEJMoa1613683. PMID: 28212060Free PMC Article
Everolimus.
Houghton PJ
Clin Cancer Res 2010 Mar 1;16(5):1368-72. Epub 2010 Feb 23 doi: 10.1158/1078-0432.CCR-09-1314. PMID: 20179227Free PMC Article

Prognosis

The tumor microenvironment and immune targeting therapy in pediatric renal tumors.
Hont AB, Dumont B, Sutton KS, Anderson J, Kentsis A, Drost J, Hong AL, Verschuur A
Pediatr Blood Cancer 2023 May;70 Suppl 2:e30110. Epub 2022 Nov 30 doi: 10.1002/pbc.30110. PMID: 36451260
Renal cell carcinoma.
Hsieh JJ, Purdue MP, Signoretti S, Swanton C, Albiges L, Schmidinger M, Heng DY, Larkin J, Ficarra V
Nat Rev Dis Primers 2017 Mar 9;3:17009. doi: 10.1038/nrdp.2017.9. PMID: 28276433Free PMC Article
Pembrolizumab as Second-Line Therapy for Advanced Urothelial Carcinoma.
Bellmunt J, de Wit R, Vaughn DJ, Fradet Y, Lee JL, Fong L, Vogelzang NJ, Climent MA, Petrylak DP, Choueiri TK, Necchi A, Gerritsen W, Gurney H, Quinn DI, Culine S, Sternberg CN, Mai Y, Poehlein CH, Perini RF, Bajorin DF; KEYNOTE-045 Investigators
N Engl J Med 2017 Mar 16;376(11):1015-1026. Epub 2017 Feb 17 doi: 10.1056/NEJMoa1613683. PMID: 28212060Free PMC Article
TroVax in colorectal cancer.
Rowe J, Cen P
Hum Vaccin Immunother 2014;10(11):3196-200. doi: 10.4161/21645515.2014.973323. PMID: 25483641Free PMC Article
Everolimus.
Houghton PJ
Clin Cancer Res 2010 Mar 1;16(5):1368-72. Epub 2010 Feb 23 doi: 10.1158/1078-0432.CCR-09-1314. PMID: 20179227Free PMC Article

Clinical prediction guides

SMARCB1 regulates the hypoxic stress response in sickle cell trait.
Soeung M, Perelli L, Chen Z, Dondossola E, Ho IL, Carbone F, Zhang L, Khan H, Le CN, Zhu C, Peoples MD, Feng N, Jiang S, Zacharias NM, Minelli R, Shapiro DD, Deem AK, Gao S, Cheng EH, Lucchetti D, Walker CL, Carugo A, Giuliani V, Heffernan TP, Viale A, Tannir NM, Draetta GF, Msaouel P, Genovese G
Proc Natl Acad Sci U S A 2023 May 23;120(21):e2209639120. Epub 2023 May 15 doi: 10.1073/pnas.2209639120. PMID: 37186844Free PMC Article
Renal cell carcinoma.
Hsieh JJ, Purdue MP, Signoretti S, Swanton C, Albiges L, Schmidinger M, Heng DY, Larkin J, Ficarra V
Nat Rev Dis Primers 2017 Mar 9;3:17009. doi: 10.1038/nrdp.2017.9. PMID: 28276433Free PMC Article
Pembrolizumab as Second-Line Therapy for Advanced Urothelial Carcinoma.
Bellmunt J, de Wit R, Vaughn DJ, Fradet Y, Lee JL, Fong L, Vogelzang NJ, Climent MA, Petrylak DP, Choueiri TK, Necchi A, Gerritsen W, Gurney H, Quinn DI, Culine S, Sternberg CN, Mai Y, Poehlein CH, Perini RF, Bajorin DF; KEYNOTE-045 Investigators
N Engl J Med 2017 Mar 16;376(11):1015-1026. Epub 2017 Feb 17 doi: 10.1056/NEJMoa1613683. PMID: 28212060Free PMC Article
Everolimus.
Houghton PJ
Clin Cancer Res 2010 Mar 1;16(5):1368-72. Epub 2010 Feb 23 doi: 10.1158/1078-0432.CCR-09-1314. PMID: 20179227Free PMC Article
Sorafenib.
Rini BI
Expert Opin Pharmacother 2006 Mar;7(4):453-61. doi: 10.1517/14656566.7.4.453. PMID: 16503817

Recent systematic reviews

Programmed Death 1 and Programmed Death Ligand 1 Inhibitors in Advanced and Recurrent Urothelial Carcinoma: Meta-analysis of Single-Agent Studies.
Tafuri A, Smith DD, Cacciamani GE, Cole S, Shakir A, Sadeghi S, Vogelzang NJ, Quinn D, Gill PS, Gill IS
Clin Genitourin Cancer 2020 Oct;18(5):351-360.e3. Epub 2020 Jan 31 doi: 10.1016/j.clgc.2020.01.004. PMID: 32146152Free PMC Article
Risks and Benefits of Chimeric Antigen Receptor T-Cell (CAR-T) Therapy in Cancer: A Systematic Review and Meta-Analysis.
Grigor EJM, Fergusson D, Kekre N, Montroy J, Atkins H, Seftel MD, Daugaard M, Presseau J, Thavorn K, Hutton B, Holt RA, Lalu MM
Transfus Med Rev 2019 Apr;33(2):98-110. Epub 2019 Feb 14 doi: 10.1016/j.tmrv.2019.01.005. PMID: 30948292
Intravesical gemcitabine for non-muscle invasive bladder cancer.
Jones G, Cleves A, Wilt TJ, Mason M, Kynaston HG, Shelley M
Cochrane Database Syst Rev 2012 Jan 18;1:CD009294. doi: 10.1002/14651858.CD009294.pub2. PMID: 22259002
Investigational therapies for non-muscle invasive bladder cancer.
Smaldone MC, Casella DP, Welchons DR, Gingrich JR
Expert Opin Investig Drugs 2010 Mar;19(3):371-83. doi: 10.1517/13543780903563372. PMID: 20078248
Will targeted therapy hold its promise? An evidence-based review.
Murdoch D, Sager J
Curr Opin Oncol 2008 Jan;20(1):104-11. doi: 10.1097/CCO.0b013e3282f44b12. PMID: 18043264

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