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Malignant Genitourinary System Neoplasm

MedGen UID:
199685
•Concept ID:
C0751569
•
Neoplastic Process
Synonyms: Cancer, Genito-urinary; Cancer, Genitourinary; Cancer, Urogenital; Cancers, Genito-urinary; Cancers, Genitourinary; Cancers, Urogenital; Genito urinary Cancer; Genito-urinary Cancer; Genito-urinary Cancers; Genitourinary Cancer; Genitourinary Cancers; Urogenital Cancer; Urogenital Cancers

Definition

A primary or metastatic malignant neoplasm that affects the genitourinary system. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMalignant Genitourinary System Neoplasm

Professional guidelines

PubMed

Bladder cancer: ESMO Clinical Practice Guideline for diagnosis, treatment and follow-up.
Powles T, Bellmunt J, Comperat E, De Santis M, Huddart R, Loriot Y, Necchi A, Valderrama BP, Ravaud A, Shariat SF, Szabados B, van der Heijden MS, Gillessen S; ESMO Guidelines Committee. Electronic address: [email protected]
Ann Oncol 2022 Mar;33(3):244-258. Epub 2021 Nov 30 doi: 10.1016/j.annonc.2021.11.012. PMID: 34861372
Management of Symptomatic Uterine Leiomyomas: ACOG Practice Bulletin, Number 228.
Obstet Gynecol 2021 Jun 1;137(6):e100-e115. doi: 10.1097/AOG.0000000000004401. PMID: 34011888
Renal cell carcinoma: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up†.
Escudier B, Porta C, Schmidinger M, Rioux-Leclercq N, Bex A, Khoo V, Grünwald V, Gillessen S, Horwich A; ESMO Guidelines Committee. Electronic address: [email protected]
Ann Oncol 2019 May 1;30(5):706-720. doi: 10.1093/annonc/mdz056. PMID: 30788497

Recent clinical studies

Etiology

Lichen Sclerosus-Presentation, Diagnosis and Management.
Kirtschig G
Dtsch Arztebl Int 2016 May 13;113(19):337-43. doi: 10.3238/arztebl.2016.0337. PMID: 27232363Free PMC Article
Overview.
Platz EA
Urol Oncol 2012 Sep;30(5):727-8. doi: 10.1016/j.urolonc.2012.07.014. PMID: 23021555
Pediatric urologic oncology.
Grimsby GM, Ritchey ML
Pediatr Clin North Am 2012 Aug;59(4):947-59. Epub 2012 Jun 15 doi: 10.1016/j.pcl.2012.05.018. PMID: 22857841
Pediatric genitourinary tumors.
Castellino SM, Martinez-Borges AR, McLean TW
Curr Opin Oncol 2009 May;21(3):278-83. doi: 10.1097/CCO.0b013e328329f201. PMID: 19295433Free PMC Article
Pediatric genitourinary tumors.
Merguerian PA
Curr Opin Oncol 2003 May;15(3):222-6. doi: 10.1097/00001622-200305000-00008. PMID: 12778016

Diagnosis

Ano-uro-genital mucosal melanoma UK national guidelines.
Smith HG, Bagwan I, Board RE, Capper S, Coupland SE, Glen J, Lalondrelle S, Mayberry A, Muneer A, Nugent K, Pathiraja P, Payne M, Peach H, Smith J, Westwell S, Wilson E, Rodwell S, Gore M, Turnbull N, Smith MJF
Eur J Cancer 2020 Aug;135:22-30. Epub 2020 Jun 9 doi: 10.1016/j.ejca.2020.04.030. PMID: 32531566
Lichen Sclerosus-Presentation, Diagnosis and Management.
Kirtschig G
Dtsch Arztebl Int 2016 May 13;113(19):337-43. doi: 10.3238/arztebl.2016.0337. PMID: 27232363Free PMC Article
Pediatric urologic oncology.
Grimsby GM, Ritchey ML
Pediatr Clin North Am 2012 Aug;59(4):947-59. Epub 2012 Jun 15 doi: 10.1016/j.pcl.2012.05.018. PMID: 22857841
Pediatric genitourinary tumors.
Castellino SM, Martinez-Borges AR, McLean TW
Curr Opin Oncol 2009 May;21(3):278-83. doi: 10.1097/CCO.0b013e328329f201. PMID: 19295433Free PMC Article
Pediatric genitourinary tumors.
Prowse OA, Reddy PP, Barrieras D, Jahromi A, Merguerian PA
Curr Opin Oncol 1998 May;10(3):253-60. doi: 10.1097/00001622-199805000-00013. PMID: 9619362

Therapy

Targeting defective DNA repair in prostate cancer.
Carmichael J, Maza MLDF, Rescigno P, Chandran K, de Bono J
Curr Opin Oncol 2020 Sep;32(5):503-509. doi: 10.1097/CCO.0000000000000654. PMID: 32675592
Primary cytoreductive surgery with or without hyperthermic intraperitoneal chemotherapy (HIPEC) for FIGO stage III epithelial ovarian cancer: OVHIPEC-2, a phase III randomized clinical trial.
Koole S, van Stein R, Sikorska K, Barton D, Perrin L, Brennan D, Zivanovic O, Mosgaard BJ, Fagotti A, Colombo PE, Sonke G, Driel WJV; OVHIPEC-2 Steering Committee and the Dutch OVHIPEC group
Int J Gynecol Cancer 2020 Jun;30(6):888-892. Epub 2020 Mar 23 doi: 10.1136/ijgc-2020-001231. PMID: 32205449Free PMC Article
Immunotherapy advances in uro-genital malignancies.
Ratta R, Zappasodi R, Raggi D, Grassi P, Verzoni E, Necchi A, Di Nicola M, Salvioni R, de Braud F, Procopio G
Crit Rev Oncol Hematol 2016 Sep;105:52-64. Epub 2016 Jun 17 doi: 10.1016/j.critrevonc.2016.06.012. PMID: 27372200
Lichen Sclerosus-Presentation, Diagnosis and Management.
Kirtschig G
Dtsch Arztebl Int 2016 May 13;113(19):337-43. doi: 10.3238/arztebl.2016.0337. PMID: 27232363Free PMC Article
A primer on clinical trial design.
Ellimoottil C, Vijan S, Flanigan RC
Urol Oncol 2015 Mar;33(3):116-21. Epub 2015 Jan 23 doi: 10.1016/j.urolonc.2014.12.014. PMID: 25624092

Prognosis

Estimates of incidence and mortality of cervical cancer in 2018: a worldwide analysis.
Arbyn M, Weiderpass E, Bruni L, de Sanjosé S, Saraiya M, Ferlay J, Bray F
Lancet Glob Health 2020 Feb;8(2):e191-e203. Epub 2019 Dec 4 doi: 10.1016/S2214-109X(19)30482-6. PMID: 31812369Free PMC Article
Cervical Cancer Prevalence, Incidence and Mortality in Low and Middle Income Countries: A Systematic Review.
Shrestha AD, Neupane D, Vedsted P, Kallestrup P
Asian Pac J Cancer Prev 2018 Feb 26;19(2):319-324. doi: 10.22034/APJCP.2018.19.2.319. PMID: 29479954Free PMC Article
Lichen Sclerosus-Presentation, Diagnosis and Management.
Kirtschig G
Dtsch Arztebl Int 2016 May 13;113(19):337-43. doi: 10.3238/arztebl.2016.0337. PMID: 27232363Free PMC Article
Pediatric urologic oncology.
Grimsby GM, Ritchey ML
Pediatr Clin North Am 2012 Aug;59(4):947-59. Epub 2012 Jun 15 doi: 10.1016/j.pcl.2012.05.018. PMID: 22857841
Pediatric genitourinary tumors.
Merguerian PA
Curr Opin Oncol 2003 May;15(3):222-6. doi: 10.1097/00001622-200305000-00008. PMID: 12778016

Clinical prediction guides

Role of cystatin C in urogenital malignancy.
Ding L, Liu Z, Wang J
Front Endocrinol (Lausanne) 2022;13:1082871. Epub 2022 Dec 14 doi: 10.3389/fendo.2022.1082871. PMID: 36589819Free PMC Article
Clinical applications of artificial intelligence in urologic oncology.
Hosein S, Reitblat CR, Cone EB, Trinh QD
Curr Opin Urol 2020 Nov;30(6):748-753. doi: 10.1097/MOU.0000000000000819. PMID: 32941255
Pathomics in urology.
Schuettfort VM, Pradere B, Rink M, Comperat E, Shariat SF
Curr Opin Urol 2020 Nov;30(6):823-831. doi: 10.1097/MOU.0000000000000813. PMID: 32881725
Multiparametric Magnetic Resonance Imaging for Bladder Cancer: Development of VI-RADS (Vesical Imaging-Reporting And Data System).
Panebianco V, Narumi Y, Altun E, Bochner BH, Efstathiou JA, Hafeez S, Huddart R, Kennish S, Lerner S, Montironi R, Muglia VF, Salomon G, Thomas S, Vargas HA, Witjes JA, Takeuchi M, Barentsz J, Catto JWF
Eur Urol 2018 Sep;74(3):294-306. Epub 2018 May 10 doi: 10.1016/j.eururo.2018.04.029. PMID: 29755006Free PMC Article
Pediatric genitourinary tumors.
Merguerian PA
Curr Opin Oncol 2003 May;15(3):222-6. doi: 10.1097/00001622-200305000-00008. PMID: 12778016

Recent systematic reviews

EAU-EANM-ESTRO-ESUR-ISUP-SIOG Guidelines on Prostate Cancer-2024 Update. Part I: Screening, Diagnosis, and Local Treatment with Curative Intent.
Cornford P, van den Bergh RCN, Briers E, Van den Broeck T, Brunckhorst O, Darraugh J, Eberli D, De Meerleer G, De Santis M, Farolfi A, Gandaglia G, Gillessen S, Grivas N, Henry AM, Lardas M, van Leenders GJLH, Liew M, Linares Espinos E, Oldenburg J, van Oort IM, Oprea-Lager DE, Ploussard G, Roberts MJ, Rouvière O, Schoots IG, Schouten N, Smith EJ, Stranne J, Wiegel T, Willemse PM, Tilki D
Eur Urol 2024 Aug;86(2):148-163. Epub 2024 Apr 13 doi: 10.1016/j.eururo.2024.03.027. PMID: 38614820
2022 Update on Prostate Cancer Epidemiology and Risk Factors-A Systematic Review.
Bergengren O, Pekala KR, Matsoukas K, Fainberg J, Mungovan SF, Bratt O, Bray F, Brawley O, Luckenbaugh AN, Mucci L, Morgan TM, Carlsson SV
Eur Urol 2023 Aug;84(2):191-206. Epub 2023 May 16 doi: 10.1016/j.eururo.2023.04.021. PMID: 37202314Free PMC Article
Systematic review and meta-analysis of prediction models used in cervical cancer.
Jha AK, Mithun S, Sherkhane UB, Jaiswar V, Osong B, Purandare N, Kannan S, Prabhash K, Gupta S, Vanneste B, Rangarajan V, Dekker A, Wee L
Artif Intell Med 2023 May;139:102549. Epub 2023 Apr 11 doi: 10.1016/j.artmed.2023.102549. PMID: 37100501
Radiotherapy of oligometastatic prostate cancer: a systematic review.
Rogowski P, Roach M 3rd, Schmidt-Hegemann NS, Trapp C, von Bestenbostel R, Shi R, Buchner A, Stief C, Belka C, Li M
Radiat Oncol 2021 Mar 9;16(1):50. doi: 10.1186/s13014-021-01776-8. PMID: 33750437Free PMC Article
EAU-EANM-ESTRO-ESUR-SIOG Guidelines on Prostate Cancer-2020 Update. Part 1: Screening, Diagnosis, and Local Treatment with Curative Intent.
Mottet N, van den Bergh RCN, Briers E, Van den Broeck T, Cumberbatch MG, De Santis M, Fanti S, Fossati N, Gandaglia G, Gillessen S, Grivas N, Grummet J, Henry AM, van der Kwast TH, Lam TB, Lardas M, Liew M, Mason MD, Moris L, Oprea-Lager DE, van der Poel HG, Rouvière O, Schoots IG, Tilki D, Wiegel T, Willemse PM, Cornford P
Eur Urol 2021 Feb;79(2):243-262. Epub 2020 Nov 7 doi: 10.1016/j.eururo.2020.09.042. PMID: 33172724

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