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Malignant Urinary Tract Neoplasm

MedGen UID:: 148343
•Concept ID:: C0751571
•: Neoplastic Process

Synonyms:	Cancer of the Urinary Tract; Cancer of Urinary Tract; Cancer, Urinary Tract; Cancer, Urologic; Cancer, Urological; Cancers, Urinary Tract; Cancers, Urologic; Cancers, Urological; Urinary Tract Cancer; Urinary Tract Cancers; Urologic Cancer; Urologic Cancers; Urological Cancer; Urological Cancers
SNOMED CT:	Malignant tumor of urinary tract proper (363517008); Malignant tumor of urinary tract (363517008)

Definition

A primary or metastatic malignant neoplasm involving the urinary tract. [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVMalignant Urinary Tract Neoplasm

Pathological process
- Disease
  - Disorder by Site
    - Disorder of the genitourinary system
      - Genitourinary System Neoplasm
        Malignant Genitourinary System Neoplasm
        Malignant Urinary Tract Neoplasm
        Hereditary Malignant Urinary System Neoplasm
        Hereditary renal cell carcinoma
        Hereditary clear cell renal cell carcinoma
        Hereditary leiomyomatosis and renal cell cancer
        Hereditary papillary renal cell carcinoma
        Renal Cell Carcinoma with Constitutional Chromosome 3 Translocations
        Hereditary Wilms tumor
        Wilms tumor 1
        Wilms tumor 2
        Wilms tumor 3
        Wilms tumor 4
        Wilms tumor 5
        Malignant tumor of kidney
        Childhood malignant kidney neoplasm
        Childhood kidney cell carcinoma
        Childhood kidney Wilms tumor
        Clear cell sarcoma of kidney
        Congenital mesoblastic nephroma
        Rhabdoid tumor of the kidney
        Kidney Lymphoma
        Kidney Diffuse Large B-Cell Lymphoma
        Malignant Kidney Neoplasm Except Pelvis
        Malignant mixed epithelial stromal tumor of the kidney
        Malignant renal pelvis neoplasm
        Renal pelvis carcinoma
        Metastatic Malignant Neoplasm in the Kidney
        Nephroblastoma
        11p partial monosomy syndrome
        Adult kidney Wilms tumor
        Anaplastic Kidney Wilms Tumor
        Blastema predominant kidney Wilms tumor
        Cervical Wilms tumor
        Drash syndrome
        Epithelial predominant Wilms tumor
        Kidney Wilms tumor
        Metachronous kidney Wilms tumor
        Mixed cell type kidney Wilms tumor
        Nonanaplastic kidney Wilms tumor
        Ovarian Wilms tumor
        Paratesticular Wilms Tumor
        Prostate Wilms Tumor
        Recurrent Kidney Wilms Tumor
        Stage I Kidney Wilms Tumor
        Stage II Kidney Wilms Tumor
        Stage III Kidney Wilms Tumor
        Stage IV Kidney Wilms Tumor
        Stage V Kidney Wilms Tumor
        Stromal predominant kidney Wilms tumor
        Peripheral Primitive Neuroectodermal Tumor of the Kidney
        Renal carcinoma
        Collecting duct carcinoma
        Kidney medullary carcinoma
        Kidney Neuroendocrine Carcinoma
        Metastatic Kidney Carcinoma
        Mucinous Tubular and Spindle Cell Carcinoma of the Kidney
        Recurrent Kidney Carcinoma
        Refractory Kidney Carcinoma
        Renal cell carcinoma
        Unresectable Kidney Carcinoma
        Renal sarcoma
        Anaplastic sarcoma of the kidney
        Kidney Angiosarcoma
        Kidney Ewing Sarcoma
        Kidney fibrosarcoma
        Kidney leiomyosarcoma
        Kidney liposarcoma
        Kidney osteogenic sarcoma
        Kidney Rhabdomyosarcoma
        Kidney Synovial Sarcoma
        Malignant tumor of ureter
        Metastatic Malignant Neoplasm in the Ureter
        Regional ureteric cancer
        Ureter carcinoma
        Metastatic Ureter Carcinoma
        Recurrent Ureter Carcinoma
        Ureter adenocarcinoma
        Ureter small cell carcinoma
        Ureter squamous cell carcinoma
        Ureter transitional cell carcinoma
        Ureter Undifferentiated Carcinoma
        Ureteral lymphoma
        Malignant tumor of urinary bladder
        Bladder lymphoma
        Bladder Mucosa-Associated Lymphoid Tissue Lymphoma
        Bladder Malignant PEComa
        Bladder Melanoma
        Bladder sarcoma
        Bladder Alveolar Soft Part Sarcoma
        Bladder Angiosarcoma
        Bladder Leiomyosarcoma
        Bladder Rhabdomyosarcoma
        Metastatic Bladder Paraganglioma
        Metastatic Malignant Neoplasm in the Bladder
        Recurrent Malignant Bladder Neoplasm
        Recurrent Bladder Carcinoma
        Urinary bladder carcinoma
        Bladder adenocarcinoma
        Bladder Cancer by AJCC v6 Stage
        Bladder Cancer by AJCC v7 Stage
        Bladder Cancer by AJCC v8 Stage
        Bladder Neuroendocrine Carcinoma
        Bladder squamous cell carcinoma
        Bladder urachal carcinoma
        Carcinoma Arising in Bladder Diverticulum
        Childhood bladder carcinoma
        Metastatic Bladder Carcinoma
        Refractory Bladder Carcinoma
        Transitional cell carcinoma of the bladder
        Unresectable Bladder Carcinoma
        Metastatic Malignant Neoplasm in the Urinary System
        Metastatic Malignant Neoplasm in the Urethra
        Mucosal Melanoma of the Urinary System
        Urethral Melanoma
        Recurrent Malignant Urinary System Neoplasm
        Recurrent Rhabdoid Tumor of the Kidney
        Recurrent Urinary System Carcinoma
        Recurrent Urethral Carcinoma
        Recurrent Urothelial Carcinoma
        Refractory Malignant Urinary System Neoplasm
        Refractory Rhabdoid Tumor of the Kidney
        Refractory Urinary System Carcinoma
        Refractory Urothelial Carcinoma
        Urethra cancer
        Anterior urethra cancer
        Female urethral cancer
        Male urethral cancer
        Bulbomembranous urethral cancer
        Carcinoma of Cowper glands
        Littre gland carcinoma
        Penile urethral cancer
        Prostatic urethral cancer
        Malignant Accessory Urethral Gland Neoplasm
        Accessory Urethral Gland Adenocarcinoma
        Posterior urethra cancer
        Urethral Carcinoma
        Distal Urethral Carcinoma
        Metastatic Urethral Carcinoma
        Proximal Urethral Carcinoma
        Urethra adenocarcinoma
        Urethra squamous cell carcinoma
        Urethra transitional cell carcinoma
        Urethral Cancer by AJCC v7 Stage
        Urethral Cancer by AJCC v8 Stage
        Urethral Undifferentiated Carcinoma
        Urinary System Carcinoma
        Renal Pelvis and Ureter Carcinoma
        Upper tract urothelial carcinoma
        Urothelial carcinoma
        Infiltrating urothelial carcinoma
        Metastatic Urothelial Carcinoma
        Primary prostate urothelial carcinoma
        Unresectable Urothelial Carcinoma
        Urothelial Carcinoma, High Grade

Professional guidelines

PubMed

Advances in diagnosis and treatment of bladder cancer.

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Lancet 2022 Nov 12;400(10364):1712-1721. Epub 2022 Sep 26 doi: 10.1016/S0140-6736(22)01188-6. PMID: 36174585

Renal cell carcinoma: an overview of the epidemiology, diagnosis, and treatment.

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Recent clinical studies

Etiology

Urinary Tract Cytopathology: Current and Future Impact on Patient Care.

Jorda M, Kryvenko ON, Hanly F, Zuo Y
Surg Pathol Clin 2024 Sep;17(3):383-394. Epub 2024 Jul 14 doi: 10.1016/j.path.2024.06.001. PMID: 39129138

Hematuria.

Peterson LM, Reed HS
Prim Care 2019 Jun;46(2):265-273. Epub 2019 Apr 1 doi: 10.1016/j.pop.2019.02.008. PMID: 31030828

Urologic malignancies in kidney transplantation.

Hickman LA, Sawinski D, Guzzo T, Locke JE
Am J Transplant 2018 Jan;18(1):13-22. Epub 2017 Dec 1 doi: 10.1111/ajt.14533. PMID: 28985026

Complications Following Radical Nephroureterectomy.

Raman JD, Jafri SM
Curr Urol Rep 2016 May;17(5):36. doi: 10.1007/s11934-016-0595-1. PMID: 26968416

Treatment of patients with metastatic urothelial cancer "unfit" for Cisplatin-based chemotherapy.

Galsky MD, Hahn NM, Rosenberg J, Sonpavde G, Hutson T, Oh WK, Dreicer R, Vogelzang N, Sternberg CN, Bajorin DF, Bellmunt J
J Clin Oncol 2011 Jun 10;29(17):2432-8. Epub 2011 May 9 doi: 10.1200/JCO.2011.34.8433. PMID: 21555688

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Diagnosis

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Med Res Rev 2024 Jul;44(4):1662-1682. Epub 2024 Feb 1 doi: 10.1002/med.22025. PMID: 38299968

Hematuria.

Peterson LM, Reed HS
Prim Care 2019 Jun;46(2):265-273. Epub 2019 Apr 1 doi: 10.1016/j.pop.2019.02.008. PMID: 31030828

Upper tract urothelial cancer.

Froemming A, Potretzke T, Takahashi N, Kim B
Eur J Radiol 2018 Jan;98:50-60. Epub 2017 Nov 8 doi: 10.1016/j.ejrad.2017.10.021. PMID: 29279170

Rare urologic tumors.

McCormick B, Dahmen A, Antar A, Baumgarten A, Dhillon J, Spiess PE
Curr Opin Urol 2017 Jan;27(1):68-75. doi: 10.1097/MOU.0000000000000356. PMID: 27798414

Genomics in upper tract urothelial carcinoma.

Kammerer-Jacquet SF, Mathieu R, Peyronnet B, Rioux-Leclercq N, Bensalah K
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Therapy

Enfortumab Vedotin in Previously Treated Advanced Urothelial Carcinoma.

Powles T, Rosenberg JE, Sonpavde GP, Loriot Y, Durán I, Lee JL, Matsubara N, Vulsteke C, Castellano D, Wu C, Campbell M, Matsangou M, Petrylak DP
N Engl J Med 2021 Mar 25;384(12):1125-1135. Epub 2021 Feb 12 doi: 10.1056/NEJMoa2035807. PMID: 33577729 Free PMC Article

Clinical efficacy and biomarker analysis of neoadjuvant atezolizumab in operable urothelial carcinoma in the ABACUS trial.

Powles T, Kockx M, Rodriguez-Vida A, Duran I, Crabb SJ, Van Der Heijden MS, Szabados B, Pous AF, Gravis G, Herranz UA, Protheroe A, Ravaud A, Maillet D, Mendez MJ, Suarez C, Linch M, Prendergast A, van Dam PJ, Stanoeva D, Daelemans S, Mariathasan S, Tea JS, Mousa K, Banchereau R, Castellano D
Nat Med 2019 Nov;25(11):1706-1714. Epub 2019 Nov 4 doi: 10.1038/s41591-019-0628-7. PMID: 31686036

Urologic malignancies in kidney transplantation.

Hickman LA, Sawinski D, Guzzo T, Locke JE
Am J Transplant 2018 Jan;18(1):13-22. Epub 2017 Dec 1 doi: 10.1111/ajt.14533. PMID: 28985026

Complications Following Radical Nephroureterectomy.

Raman JD, Jafri SM
Curr Urol Rep 2016 May;17(5):36. doi: 10.1007/s11934-016-0595-1. PMID: 26968416

Treatment of patients with metastatic urothelial cancer "unfit" for Cisplatin-based chemotherapy.

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Prognosis

URINE CYTOLOGY AND AXILLARY TESTING FOR INTERPRETATION AND FOLLOW-UP OF URINARY TUMORS.

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Randomized phase III KEYNOTE-045 trial of pembrolizumab versus paclitaxel, docetaxel, or vinflunine in recurrent advanced urothelial cancer: results of >2 years of follow-up.

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Ann Oncol 2019 Jun 1;30(6):970-976. doi: 10.1093/annonc/mdz127. PMID: 31050707 Free PMC Article

Current Management for Pediatric Urologic Oncology.

Caldwell BT, Wilcox DT, Cost NG
Adv Pediatr 2017 Aug;64(1):191-223. doi: 10.1016/j.yapd.2017.04.001. PMID: 28688589

Urologic cancer in Taiwan.

Hung CF, Yang CK, Ou YC
Jpn J Clin Oncol 2016 Jul;46(7):605-9. Epub 2016 Apr 6 doi: 10.1093/jjco/hyw038. PMID: 27052114

Smoking and urological disease.

Mikhailidis DP, Ganotakis ES, Papadakis JA, Jeremy JY
J R Soc Promot Health 1998 Aug;118(4):210-2. doi: 10.1177/146642409811800404. PMID: 10076669

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Clinical prediction guides

Targeted Molecular Imaging as a Biomarker in Urologic Oncology.

Haj-Mirzaian A, Mahmood U, Heidari P
Urol Clin North Am 2023 Feb;50(1):115-131. doi: 10.1016/j.ucl.2022.09.011. PMID: 36424076 Free PMC Article

Immunotherapy and urothelial carcinoma: An overview and future prospectives.

Pierantoni F, Maruzzo M, Gardi M, Bezzon E, Gardiman MP, Porreca A, Basso U, Zagonel V
Crit Rev Oncol Hematol 2019 Nov;143:46-55. Epub 2019 Aug 26 doi: 10.1016/j.critrevonc.2019.08.005. PMID: 31476551

Multiparametric Magnetic Resonance Imaging for Bladder Cancer: Development of VI-RADS (Vesical Imaging-Reporting And Data System).

Panebianco V, Narumi Y, Altun E, Bochner BH, Efstathiou JA, Hafeez S, Huddart R, Kennish S, Lerner S, Montironi R, Muglia VF, Salomon G, Thomas S, Vargas HA, Witjes JA, Takeuchi M, Barentsz J, Catto JWF
Eur Urol 2018 Sep;74(3):294-306. Epub 2018 May 10 doi: 10.1016/j.eururo.2018.04.029. PMID: 29755006 Free PMC Article

Malignant ureteric obstruction decompression: how much gain for how much pain? A narrative review.

Prentice J, Amer T, Tasleem A, Aboumarzouk O
J R Soc Med 2018 Apr;111(4):125-135. doi: 10.1177/0141076818766725. PMID: 29648512 Free PMC Article

Nephrogenic adenoma.

Amin W, Parwani AV
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Recent systematic reviews

Epidemiology of Bladder Cancer in 2023: A Systematic Review of Risk Factors.

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Eur Urol 2023 Aug;84(2):176-190. Epub 2023 May 16 doi: 10.1016/j.eururo.2023.03.029. PMID: 37198015

Epidemiology of Renal Cell Carcinoma: 2022 Update.

Bukavina L, Bensalah K, Bray F, Carlo M, Challacombe B, Karam JA, Kassouf W, Mitchell T, Montironi R, O'Brien T, Panebianco V, Scelo G, Shuch B, van Poppel H, Blosser CD, Psutka SP
Eur Urol 2022 Nov;82(5):529-542. Epub 2022 Sep 10 doi: 10.1016/j.eururo.2022.08.019. PMID: 36100483

Management of Metastatic Clear Cell Renal Cell Carcinoma: ASCO Guideline.

Rathmell WK, Rumble RB, Van Veldhuizen PJ, Al-Ahmadie H, Emamekhoo H, Hauke RJ, Louie AV, Milowsky MI, Molina AM, Rose TL, Siva S, Zaorsky NG, Zhang T, Qamar R, Kungel TM, Lewis B, Singer EA
J Clin Oncol 2022 Sep 1;40(25):2957-2995. Epub 2022 Jun 21 doi: 10.1200/JCO.22.00868. PMID: 35728020

Air pollution exposure and bladder, kidney and urinary tract cancer risk: A systematic review.

Zare Sakhvidi MJ, Lequy E, Goldberg M, Jacquemin B
Environ Pollut 2020 Dec;267:115328. Epub 2020 Aug 20 doi: 10.1016/j.envpol.2020.115328. PMID: 32871482

Diagnosis and Treatment of Non-Muscle Invasive Bladder Cancer: AUA/SUO Guideline.

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