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Squamous Dysplasia

MedGen UID:
1668677
•Concept ID:
C4727465
•
Finding

Definition

A morphologic finding indicating the presence of dysplasia in the squamous epithelium of a tissue sample. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSquamous Dysplasia

Professional guidelines

PubMed

Advances in diagnosis and management of cancer of the esophagus.
Deboever N, Jones CM, Yamashita K, Ajani JA, Hofstetter WL
BMJ 2024 Jun 3;385:e074962. doi: 10.1136/bmj-2023-074962. PMID: 38830686
Management of Laryngeal Dysplasia and Early Invasive Cancer.
Hrelec C
Curr Treat Options Oncol 2021 Aug 23;22(10):90. doi: 10.1007/s11864-021-00881-w. PMID: 34424405
Endoscopic Management of Early Adenocarcinoma and Squamous Cell Carcinoma of the Esophagus: Screening, Diagnosis, and Therapy.
di Pietro M, Canto MI, Fitzgerald RC
Gastroenterology 2018 Jan;154(2):421-436. Epub 2017 Aug 2 doi: 10.1053/j.gastro.2017.07.041. PMID: 28778650Free PMC Article

Recent clinical studies

Etiology

Squamous Neoplastic Precursor Lesions of the Esophagus.
Arai T, Ono S, Takubo K
Gastroenterol Clin North Am 2024 Mar;53(1):25-38. Epub 2023 Oct 23 doi: 10.1016/j.gtc.2023.09.004. PMID: 38280749
Human Papillomavirus-Related Carcinoma With Adenoid Cystic-like Features of the Sinonasal Tract (Also Known as Human Papillomavirus-Related Multiphenotypic Sinonasal Carcinoma).
Chen CC, Yang SF
Arch Pathol Lab Med 2019 Nov;143(11):1420-1424. Epub 2019 Mar 6 doi: 10.5858/arpa.2018-0027-RS. PMID: 30838880
Precursor lesions of the urinary bladder.
McKenney JK
Histopathology 2019 Jan;74(1):68-76. doi: 10.1111/his.13762. PMID: 30565304
Pulmonary preinvasive neoplasia.
Kerr KM
J Clin Pathol 2001 Apr;54(4):257-71. doi: 10.1136/jcp.54.4.257. PMID: 11304841Free PMC Article
The postpartum Papanicolaou smear.
Weiss BD, Senf JH, Udall W
J Am Board Fam Pract 1989 Jan-Mar;2(1):4-9. PMID: 2538045

Diagnosis

Advances in diagnosis and management of cancer of the esophagus.
Deboever N, Jones CM, Yamashita K, Ajani JA, Hofstetter WL
BMJ 2024 Jun 3;385:e074962. doi: 10.1136/bmj-2023-074962. PMID: 38830686
Anal and Perianal Preneoplastic Lesions.
Loughrey MB, Shepherd NA
Gastroenterol Clin North Am 2024 Mar;53(1):201-220. Epub 2023 Oct 16 doi: 10.1016/j.gtc.2023.09.007. PMID: 38280748
Squamous Neoplasia in the Esophagus.
Savant D, Zhang Q, Yang Z
Arch Pathol Lab Med 2021 May 1;145(5):554-561. doi: 10.5858/arpa.2020-0058-RA. PMID: 32271610
Human Papillomavirus-Related Carcinoma With Adenoid Cystic-like Features of the Sinonasal Tract (Also Known as Human Papillomavirus-Related Multiphenotypic Sinonasal Carcinoma).
Chen CC, Yang SF
Arch Pathol Lab Med 2019 Nov;143(11):1420-1424. Epub 2019 Mar 6 doi: 10.5858/arpa.2018-0027-RS. PMID: 30838880
The postpartum Papanicolaou smear.
Weiss BD, Senf JH, Udall W
J Am Board Fam Pract 1989 Jan-Mar;2(1):4-9. PMID: 2538045

Therapy

Periocular and ocular surface nonmelanoma skin cancer.
Hooper J, Shao K, Feng PW, Falcone M, Feng H
Clin Dermatol 2024 Jan-Feb;42(1):71-77. Epub 2023 Oct 20 doi: 10.1016/j.clindermatol.2023.10.011. PMID: 37866412
Short-term and long-term effect of nutrition intervention in the Linxian Dysplasia Nutrition Intervention Trial and the reason for disappearance of the intervention effect: A cohort study.
Fan JH, Sun WY, Yang H, Wang XK, Abnet CC, Qiao YL
Cancer 2023 Aug 1;129(15):2360-2372. Epub 2023 May 27 doi: 10.1002/cncr.34761. PMID: 37243894
miRNAs Involved in Esophageal Carcinogenesis and miRNA-Related Therapeutic Perspectives in Esophageal Carcinoma.
Zarrilli G, Galuppini F, Angerilli V, Munari G, Sabbadin M, Lazzarin V, Nicolè L, Biancotti R, Fassan M
Int J Mol Sci 2021 Mar 31;22(7) doi: 10.3390/ijms22073640. PMID: 33807389Free PMC Article
Hydroxyurea-associated squamous dysplasia.
Sanchez-Palacios C, Guitart J
J Am Acad Dermatol 2004 Aug;51(2):293-300. doi: 10.1016/j.jaad.2003.11.059. PMID: 15280852
Squamous cell carcinoma of the eyelid.
Reifler DM, Hornblass A
Surv Ophthalmol 1986 May-Jun;30(6):349-65. doi: 10.1016/0039-6257(86)90089-5. PMID: 3523806

Prognosis

Esophageal squamous dysplasia and cancer: Is artificial intelligence our best weapon?
Hussein M, Everson M, Haidry R
Best Pract Res Clin Gastroenterol 2021 Jun-Aug;52-53:101723. Epub 2020 Dec 29 doi: 10.1016/j.bpg.2020.101723. PMID: 34172257
Human Papillomavirus-Related Carcinoma With Adenoid Cystic-like Features of the Sinonasal Tract (Also Known as Human Papillomavirus-Related Multiphenotypic Sinonasal Carcinoma).
Chen CC, Yang SF
Arch Pathol Lab Med 2019 Nov;143(11):1420-1424. Epub 2019 Mar 6 doi: 10.5858/arpa.2018-0027-RS. PMID: 30838880
Pathology of lung cancer.
Travis WD
Clin Chest Med 2002 Mar;23(1):65-81, viii. doi: 10.1016/s0272-5231(03)00061-3. PMID: 11901921
The topography and invasive potential of cervical adenocarcinoma in situ, with and without associated squamous dysplasia.
Colgan TJ, Lickrish GM
Gynecol Oncol 1990 Feb;36(2):246-9. doi: 10.1016/0090-8258(90)90182-k. PMID: 2298414
The postpartum Papanicolaou smear.
Weiss BD, Senf JH, Udall W
J Am Board Fam Pract 1989 Jan-Mar;2(1):4-9. PMID: 2538045

Clinical prediction guides

Esophageal squamous dysplasia and cancer: Is artificial intelligence our best weapon?
Hussein M, Everson M, Haidry R
Best Pract Res Clin Gastroenterol 2021 Jun-Aug;52-53:101723. Epub 2020 Dec 29 doi: 10.1016/j.bpg.2020.101723. PMID: 34172257
Genetic Alterations in Esophageal Tissues From Squamous Dysplasia to Carcinoma.
Liu X, Zhang M, Ying S, Zhang C, Lin R, Zheng J, Zhang G, Tian D, Guo Y, Du C, Chen Y, Chen S, Su X, Ji J, Deng W, Li X, Qiu S, Yan R, Xu Z, Wang Y, Guo Y, Cui J, Zhuang S, Yu H, Zheng Q, Marom M, Sheng S, Zhang G, Hu S, Li R, Su M
Gastroenterology 2017 Jul;153(1):166-177. Epub 2017 Mar 30 doi: 10.1053/j.gastro.2017.03.033. PMID: 28365443
Chromoendoscopy and magnification endoscopy for diagnosing esophageal cancer and dysplasia.
Connor MJ, Sharma P
Thorac Surg Clin 2004 Feb;14(1):87-94. doi: 10.1016/S1547-4127(04)00042-8. PMID: 15382312
Precursors to pulmonary neoplasia.
Colby TV, Wistuba II, Gazdar A
Adv Anat Pathol 1998 Jul;5(4):205-15. doi: 10.1097/00125480-199807000-00001. PMID: 9859753
The postpartum Papanicolaou smear.
Weiss BD, Senf JH, Udall W
J Am Board Fam Pract 1989 Jan-Mar;2(1):4-9. PMID: 2538045

Recent systematic reviews

Safety and efficacy of a minimally invasive cell sampling device ('Cytosponge') in the diagnosis of esophageal pathology: a systematic review.
Iqbal U, Siddique O, Ovalle A, Anwar H, Moss SF
Eur J Gastroenterol Hepatol 2018 Nov;30(11):1261-1269. doi: 10.1097/MEG.0000000000001210. PMID: 30044236
Markers of Vitamin D Exposure and Esophageal Cancer Risk: A Systematic Review and Meta-analysis.
Zgaga L, O'Sullivan F, Cantwell MM, Murray LJ, Thota PN, Coleman HG
Cancer Epidemiol Biomarkers Prev 2016 Jun;25(6):877-86. Epub 2016 Mar 30 doi: 10.1158/1055-9965.EPI-15-1162. PMID: 27030602

Supplemental Content

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    Practice guidelines

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      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

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