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Dysplasia

MedGen UID:
87191
Concept ID:
C0334044
Congenital Abnormality
Synonyms: Dyscrasia; Dysplastic
SNOMED CT: Dysplasia (25723000)

Definition

A usually neoplastic transformation of the cell, associated with altered architectural tissue patterns. The cellular changes include nuclear and cytoplasmic abnormalities. Molecular genetic abnormalities are also often found and, in some instances, may lead to cancer. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDysplasia

Professional guidelines

PubMed

Ohtsuka T, Fernandez-Del Castillo C, Furukawa T, Hijioka S, Jang JY, Lennon AM, Miyasaka Y, Ohno E, Salvia R, Wolfgang CL, Wood LD
Pancreatology 2024 Mar;24(2):255-270. Epub 2023 Dec 28 doi: 10.1016/j.pan.2023.12.009. PMID: 38182527
Sekeres MA, Taylor J
JAMA 2022 Sep 6;328(9):872-880. doi: 10.1001/jama.2022.14578. PMID: 36066514
Tanaka M, Fernández-Del Castillo C, Kamisawa T, Jang JY, Levy P, Ohtsuka T, Salvia R, Shimizu Y, Tada M, Wolfgang CL
Pancreatology 2017 Sep-Oct;17(5):738-753. Epub 2017 Jul 13 doi: 10.1016/j.pan.2017.07.007. PMID: 28735806

Recent clinical studies

Etiology

Schmidt AR, Ramamoorthy C
Paediatr Anaesth 2022 Feb;32(2):174-180. Epub 2021 Dec 15 doi: 10.1111/pan.14365. PMID: 34877749
Gilfillan M, Bhandari A, Bhandari V
BMJ 2021 Oct 20;375:n1974. doi: 10.1136/bmj.n1974. PMID: 34670756
Odell E, Kujan O, Warnakulasuriya S, Sloan P
Oral Dis 2021 Nov;27(8):1947-1976. Epub 2021 Sep 14 doi: 10.1111/odi.13993. PMID: 34418233
Harris JD, Lewis BD, Park KJ
Clin Sports Med 2021 Apr;40(2):271-288. Epub 2021 Jan 19 doi: 10.1016/j.csm.2020.11.004. PMID: 33673886
DiCaprio MR, Enneking WF
J Bone Joint Surg Am 2005 Aug;87(8):1848-64. doi: 10.2106/JBJS.D.02942. PMID: 16085630

Diagnosis

Szymczuk V, Taylor J, Boyce AM
Curr Osteoporos Rep 2023 Apr;21(2):147-153. Epub 2023 Feb 28 doi: 10.1007/s11914-023-00779-6. PMID: 36849642Free PMC Article
Odell E, Kujan O, Warnakulasuriya S, Sloan P
Oral Dis 2021 Nov;27(8):1947-1976. Epub 2021 Sep 14 doi: 10.1111/odi.13993. PMID: 34418233
Khoury MH, Gornik HL
Vasc Med 2017 Jun;22(3):248-252. Epub 2017 Apr 3 doi: 10.1177/1358863X17700716. PMID: 28367730
Webb EA, Dattani MT
Eur J Hum Genet 2010 Apr;18(4):393-7. Epub 2009 Jul 22 doi: 10.1038/ejhg.2009.125. PMID: 19623216Free PMC Article
Begelman SM, Olin JW
Curr Opin Rheumatol 2000 Jan;12(1):41-7. doi: 10.1097/00002281-200001000-00007. PMID: 10647953

Therapy

Polyzos SA, Makras P, Tournis S, Anastasilakis AD
Bone 2019 Dec;129:115048. Epub 2019 Aug 24 doi: 10.1016/j.bone.2019.115048. PMID: 31454537
Behnke J, Lemyre B, Czernik C, Zimmer KP, Ehrhardt H, Waitz M
Dtsch Arztebl Int 2019 Mar 8;116(11):177-183. doi: 10.3238/arztebl.2019.0177. PMID: 31014448Free PMC Article
Barkhuff WD, Soll RF
Neonatology 2019;115(4):411-422. Epub 2019 Apr 11 doi: 10.1159/000497328. PMID: 30974437
Klingenberg C, Wheeler KI, McCallion N, Morley CJ, Davis PG
Cochrane Database Syst Rev 2017 Oct 17;10(10):CD003666. doi: 10.1002/14651858.CD003666.pub4. PMID: 29039883Free PMC Article
Ahn SY, Chang YS, Park WS
Neonatology 2016;109(4):377-83. Epub 2016 Jun 3 doi: 10.1159/000444905. PMID: 27251746

Prognosis

Wang X, Li Y, Shi T, Bont LJ, Chu HY, Zar HJ, Wahi-Singh B, Ma Y, Cong B, Sharland E, Riley RD, Deng J, Figueras-Aloy J, Heikkinen T, Jones MH, Liese JG, Markić J, Mejias A, Nunes MC, Resch B, Satav A, Yeo KT, Simões EAF, Nair H; Respiratory Virus Global Epidemiology Network; RESCEU investigators
Lancet 2024 Mar 30;403(10433):1241-1253. Epub 2024 Feb 14 doi: 10.1016/S0140-6736(24)00138-7. PMID: 38367641
Philpot PA, Bhandari V
Expert Rev Respir Med 2019 Sep;13(9):871-884. Epub 2019 Aug 4 doi: 10.1080/17476348.2019.1648215. PMID: 31340666
Jain V, Sen B
J Pediatr Orthop B 2014 Sep;23(5):485-8. doi: 10.1097/BPB.0000000000000058. PMID: 24800790
Martin RJ, Fanaroff AA
Pediatr Neonatol 2013 Aug;54(4):228-34. Epub 2013 Mar 31 doi: 10.1016/j.pedneo.2013.03.001. PMID: 23597554
Messmann H
Best Pract Res Clin Gastroenterol 2001 Apr;15(2):249-65. doi: 10.1053/bega.2000.0172. PMID: 11355914

Clinical prediction guides

Donnan M, Anderson N, Hoq M, Donnan L
Bone Joint J 2023 Oct 1;105-B(10):1123-1130. doi: 10.1302/0301-620X.105B10.BJJ-2023-0143.R1. PMID: 37777201
Edmonds EW, Hughes JL, Bomar JD, Brooks JT, Upasani VV
JBJS Rev 2019 Dec;7(12):e5. doi: 10.2106/JBJS.RVW.19.00063. PMID: 31880623
Khoury MH, Gornik HL
Vasc Med 2017 Jun;22(3):248-252. Epub 2017 Apr 3 doi: 10.1177/1358863X17700716. PMID: 28367730
Milks KS, Hill LM, Hosseinzadeh K
Pediatr Radiol 2017 Feb;47(2):134-145. Epub 2016 Dec 1 doi: 10.1007/s00247-016-3725-5. PMID: 27904917
Lauwers GY, Riddell RH
Gut 1999 Nov;45(5):784-90. doi: 10.1136/gut.45.5.784. PMID: 10517922Free PMC Article

Recent systematic reviews

Cerezo-Cayuelas M, Pérez-Silva A, Serna-Muñoz C, Vicente A, Martínez-Beneyto Y, Cabello-Malagón I, Ortiz-Ruiz AJ
Orphanet J Rare Dis 2022 Oct 17;17(1):376. doi: 10.1186/s13023-022-02533-0. PMID: 36253866Free PMC Article
Vered M, Wright JM
Head Neck Pathol 2022 Mar;16(1):63-75. Epub 2022 Mar 21 doi: 10.1007/s12105-021-01404-7. PMID: 35312978Free PMC Article
Iocca O, Sollecito TP, Alawi F, Weinstein GS, Newman JG, De Virgilio A, Di Maio P, Spriano G, Pardiñas López S, Shanti RM
Head Neck 2020 Mar;42(3):539-555. Epub 2019 Dec 5 doi: 10.1002/hed.26006. PMID: 31803979
Norenhag J, Du J, Olovsson M, Verstraelen H, Engstrand L, Brusselaers N
BJOG 2020 Jan;127(2):171-180. Epub 2019 Jul 17 doi: 10.1111/1471-0528.15854. PMID: 31237400
Steinhorn RH
Pediatr Crit Care Med 2010 Mar;11(2 Suppl):S79-84. doi: 10.1097/PCC.0b013e3181c76cdc. PMID: 20216169Free PMC Article

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