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Submucosal 2 Invasion

MedGen UID:
1669135
Concept ID:
C4744481
Finding
Synonym: Submucosal Invasion Depth Class 2

Definition

Submucosal tumor invasion into the middle third of the submucosal tissue. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSubmucosal 2 Invasion

Professional guidelines

PubMed

Ferlitsch M, Hassan C, Bisschops R, Bhandari P, Dinis-Ribeiro M, Risio M, Paspatis GA, Moss A, Libânio D, Lorenzo-Zúñiga V, Voiosu AM, Rutter MD, Pellisé M, Moons LMG, Probst A, Awadie H, Amato A, Takeuchi Y, Repici A, Rahmi G, Koecklin HU, Albéniz E, Rockenbauer LM, Waldmann E, Messmann H, Triantafyllou K, Jover R, Gralnek IM, Dekker E, Bourke MJ
Endoscopy 2024 Jul;56(7):516-545. Epub 2024 Apr 26 doi: 10.1055/a-2304-3219. PMID: 38670139
Copland AP, Kahi CJ, Ko CW, Ginsberg GG
Clin Gastroenterol Hepatol 2024 Mar;22(3):470-479.e5. Epub 2023 Nov 28 doi: 10.1016/j.cgh.2023.10.012. PMID: 38032585
Weusten BLAM, Bisschops R, Dinis-Ribeiro M, di Pietro M, Pech O, Spaander MCW, Baldaque-Silva F, Barret M, Coron E, Fernández-Esparrach G, Fitzgerald RC, Jansen M, Jovani M, Marques-de-Sa I, Rattan A, Tan WK, Verheij EPD, Zellenrath PA, Triantafyllou K, Pouw RE
Endoscopy 2023 Dec;55(12):1124-1146. Epub 2023 Oct 9 doi: 10.1055/a-2176-2440. PMID: 37813356

Recent clinical studies

Etiology

Pimentel-Nunes P, Libânio D, Bastiaansen BAJ, Bhandari P, Bisschops R, Bourke MJ, Esposito G, Lemmers A, Maselli R, Messmann H, Pech O, Pioche M, Vieth M, Weusten BLAM, van Hooft JE, Deprez PH, Dinis-Ribeiro M
Endoscopy 2022 Jun;54(6):591-622. Epub 2022 May 6 doi: 10.1055/a-1811-7025. PMID: 35523224
Zwager LW, Bastiaansen BAJ, Montazeri NSM, Hompes R, Barresi V, Ichimasa K, Kawachi H, Machado I, Masaki T, Sheng W, Tanaka S, Togashi K, Yasue C, Fockens P, Moons LMG, Dekker E
Gastroenterology 2022 Jul;163(1):174-189. Epub 2022 Apr 15 doi: 10.1053/j.gastro.2022.04.010. PMID: 35436498
Draganov PV, Wang AY, Othman MO, Fukami N
Clin Gastroenterol Hepatol 2019 Jan;17(1):16-25.e1. Epub 2018 Aug 2 doi: 10.1016/j.cgh.2018.07.041. PMID: 30077787
Hatta W, Gotoda T, Oyama T, Kawata N, Takahashi A, Yoshifuku Y, Hoteya S, Nakagawa M, Hirano M, Esaki M, Matsuda M, Ohnita K, Yamanouchi K, Yoshida M, Dohi O, Takada J, Tanaka K, Yamada S, Tsuji T, Ito H, Hayashi Y, Nakaya N, Nakamura T, Shimosegawa T
Am J Gastroenterol 2017 Jun;112(6):874-881. Epub 2017 Apr 11 doi: 10.1038/ajg.2017.95. PMID: 28397873
Greene BJ, Topf MC, Meyers SP, Man LX
JAMA Otolaryngol Head Neck Surg 2014 Feb;140(2):177-8. doi: 10.1001/jamaoto.2013.5885. PMID: 24309710

Diagnosis

Liu-Burdowski J, Park J
Surg Clin North Am 2025 Feb;105(1):55-63. Epub 2024 Aug 1 doi: 10.1016/j.suc.2024.06.006. PMID: 39523076
Weusten BLAM, Bisschops R, Dinis-Ribeiro M, di Pietro M, Pech O, Spaander MCW, Baldaque-Silva F, Barret M, Coron E, Fernández-Esparrach G, Fitzgerald RC, Jansen M, Jovani M, Marques-de-Sa I, Rattan A, Tan WK, Verheij EPD, Zellenrath PA, Triantafyllou K, Pouw RE
Endoscopy 2023 Dec;55(12):1124-1146. Epub 2023 Oct 9 doi: 10.1055/a-2176-2440. PMID: 37813356
Pimentel-Nunes P, Libânio D, Bastiaansen BAJ, Bhandari P, Bisschops R, Bourke MJ, Esposito G, Lemmers A, Maselli R, Messmann H, Pech O, Pioche M, Vieth M, Weusten BLAM, van Hooft JE, Deprez PH, Dinis-Ribeiro M
Endoscopy 2022 Jun;54(6):591-622. Epub 2022 May 6 doi: 10.1055/a-1811-7025. PMID: 35523224
Mareth K, Gurm H, Madhoun MF
Gastrointest Endosc Clin N Am 2022 Apr;32(2):227-240. Epub 2022 Feb 22 doi: 10.1016/j.giec.2021.12.003. PMID: 35361333
Tanaka S, Kashida H, Saito Y, Yahagi N, Yamano H, Saito S, Hisabe T, Yao T, Watanabe M, Yoshida M, Saitoh Y, Tsuruta O, Sugihara KI, Igarashi M, Toyonaga T, Ajioka Y, Kusunoki M, Koike K, Fujimoto K, Tajiri H
Dig Endosc 2020 Jan;32(2):219-239. Epub 2019 Dec 27 doi: 10.1111/den.13545. PMID: 31566804

Therapy

Weusten BLAM, Bisschops R, Dinis-Ribeiro M, di Pietro M, Pech O, Spaander MCW, Baldaque-Silva F, Barret M, Coron E, Fernández-Esparrach G, Fitzgerald RC, Jansen M, Jovani M, Marques-de-Sa I, Rattan A, Tan WK, Verheij EPD, Zellenrath PA, Triantafyllou K, Pouw RE
Endoscopy 2023 Dec;55(12):1124-1146. Epub 2023 Oct 9 doi: 10.1055/a-2176-2440. PMID: 37813356
Loddo A, Djokovic D, Drizi A, De Vree BP, Sedrati A, van Herendael BJ
Eur J Obstet Gynecol Reprod Biol 2022 Jan;268:121-128. Epub 2021 Dec 1 doi: 10.1016/j.ejogrb.2021.11.434. PMID: 34902749
Valentine LN, Bradley LD
Clin Obstet Gynecol 2017 Jun;60(2):231-244. doi: 10.1097/GRF.0000000000000287. PMID: 28406809
Inoue H, Minami H, Kobayashi Y, Sato Y, Kaga M, Suzuki M, Satodate H, Odaka N, Itoh H, Kudo S
Endoscopy 2010 Apr;42(4):265-71. Epub 2010 Mar 30 doi: 10.1055/s-0029-1244080. PMID: 20354937
Advincula AP, Song A
Semin Reprod Med 2004 May;22(2):149-55. doi: 10.1055/s-2004-828621. PMID: 15164310

Prognosis

Zwager LW, Bastiaansen BAJ, Montazeri NSM, Hompes R, Barresi V, Ichimasa K, Kawachi H, Machado I, Masaki T, Sheng W, Tanaka S, Togashi K, Yasue C, Fockens P, Moons LMG, Dekker E
Gastroenterology 2022 Jul;163(1):174-189. Epub 2022 Apr 15 doi: 10.1053/j.gastro.2022.04.010. PMID: 35436498
Draganov PV, Wang AY, Othman MO, Fukami N
Clin Gastroenterol Hepatol 2019 Jan;17(1):16-25.e1. Epub 2018 Aug 2 doi: 10.1016/j.cgh.2018.07.041. PMID: 30077787
Hatta W, Gotoda T, Oyama T, Kawata N, Takahashi A, Yoshifuku Y, Hoteya S, Nakagawa M, Hirano M, Esaki M, Matsuda M, Ohnita K, Yamanouchi K, Yoshida M, Dohi O, Takada J, Tanaka K, Yamada S, Tsuji T, Ito H, Hayashi Y, Nakaya N, Nakamura T, Shimosegawa T
Am J Gastroenterol 2017 Jun;112(6):874-881. Epub 2017 Apr 11 doi: 10.1038/ajg.2017.95. PMID: 28397873
Greene BJ, Topf MC, Meyers SP, Man LX
JAMA Otolaryngol Head Neck Surg 2014 Feb;140(2):177-8. doi: 10.1001/jamaoto.2013.5885. PMID: 24309710
Crissman JD, Zarbo RJ
Am J Surg Pathol 1989;13 Suppl 1:5-16. PMID: 2699168

Clinical prediction guides

Zwager LW, Bastiaansen BAJ, Montazeri NSM, Hompes R, Barresi V, Ichimasa K, Kawachi H, Machado I, Masaki T, Sheng W, Tanaka S, Togashi K, Yasue C, Fockens P, Moons LMG, Dekker E
Gastroenterology 2022 Jul;163(1):174-189. Epub 2022 Apr 15 doi: 10.1053/j.gastro.2022.04.010. PMID: 35436498
Draganov PV, Wang AY, Othman MO, Fukami N
Clin Gastroenterol Hepatol 2019 Jan;17(1):16-25.e1. Epub 2018 Aug 2 doi: 10.1016/j.cgh.2018.07.041. PMID: 30077787
Burgess NG, Hourigan LF, Zanati SA, Brown GJ, Singh R, Williams SJ, Raftopoulos SC, Ormonde D, Moss A, Byth K, Mahajan H, McLeod D, Bourke MJ
Gastroenterology 2017 Sep;153(3):732-742.e1. Epub 2017 Jun 2 doi: 10.1053/j.gastro.2017.05.047. PMID: 28583826
Hatta W, Gotoda T, Oyama T, Kawata N, Takahashi A, Yoshifuku Y, Hoteya S, Nakagawa M, Hirano M, Esaki M, Matsuda M, Ohnita K, Yamanouchi K, Yoshida M, Dohi O, Takada J, Tanaka K, Yamada S, Tsuji T, Ito H, Hayashi Y, Nakaya N, Nakamura T, Shimosegawa T
Am J Gastroenterol 2017 Jun;112(6):874-881. Epub 2017 Apr 11 doi: 10.1038/ajg.2017.95. PMID: 28397873
Crissman JD, Zarbo RJ
Am J Surg Pathol 1989;13 Suppl 1:5-16. PMID: 2699168

Recent systematic reviews

Li H, Teng Y, Yan X, Cao M, Yang F, He S, Zhang S, Li Q, Xia C, Li K, Chen W
JMIR Public Health Surveill 2023 Jun 1;9:e45360. doi: 10.2196/45360. PMID: 37261899Free PMC Article
Ponte Neto FL, de Moura DTH, Sagae VMT, Ribeiro IB, Mancini FC, Boghossian MB, McCarty TR, Miyajima NT, Ide E, Bernardo WM, de Moura EGH
Surg Endosc 2021 Dec;35(12):6413-6426. Epub 2021 Aug 20 doi: 10.1007/s00464-021-08659-9. PMID: 34415431
Ferrari D, Bernardi D, Siboni S, Lazzari V, Asti E, Bonavina L
World J Surg 2021 Jan;45(1):225-234. Epub 2020 Oct 7 doi: 10.1007/s00268-020-05789-4. PMID: 33026474Free PMC Article
Wang S, Gao S, Yang W, Guo S, Li Y
Tech Coloproctol 2016 Jan;20(1):1-9. Epub 2015 Oct 30 doi: 10.1007/s10151-015-1383-5. PMID: 26519288
Nishizawa T, Suzuki H, Sagara S, Kanai T, Yahagi N
Dig Endosc 2015 Jan;27(1):8-15. Epub 2014 Dec 4 doi: 10.1111/den.12399. PMID: 25369736

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