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Metastatic Large Cell Neuroendocrine Carcinoma

MedGen UID:
1687688
•Concept ID:
C5204066
•
Neoplastic Process

Definition

A large cell neuroendocrine carcinoma that has metastasized from its original site of growth to another anatomic site. [from NCI]

Professional guidelines

PubMed

Platinum Doublet plus Atezolizumab as First-line Treatment in Metastatic Large Cell Neuroendocrine Carcinoma: A Single Institution Experience.
Vrontis K, Economidou SC, Fotopoulos G
Cancer Invest 2022 Feb;40(2):124-131. Epub 2021 Oct 21 doi: 10.1080/07357907.2021.1988962. PMID: 34601985

Recent clinical studies

Etiology

Platinum Doublet plus Atezolizumab as First-line Treatment in Metastatic Large Cell Neuroendocrine Carcinoma: A Single Institution Experience.
Vrontis K, Economidou SC, Fotopoulos G
Cancer Invest 2022 Feb;40(2):124-131. Epub 2021 Oct 21 doi: 10.1080/07357907.2021.1988962. PMID: 34601985
Prevalence and prognostic value of PD-L1 expression in molecular subtypes of metastatic large cell neuroendocrine carcinoma (LCNEC).
Hermans BCM, Derks JL, Thunnissen E, van Suylen RJ, den Bakker MA, Groen HJM, Smit EF, Damhuis RA, van den Broek EC, Stallinga CM, Roemen GM, Speel EJM, Dingemans AC; PALGA-group
Lung Cancer 2019 Apr;130:179-186. Epub 2019 Feb 21 doi: 10.1016/j.lungcan.2019.02.022. PMID: 30885341

Diagnosis

Platinum Doublet plus Atezolizumab as First-line Treatment in Metastatic Large Cell Neuroendocrine Carcinoma: A Single Institution Experience.
Vrontis K, Economidou SC, Fotopoulos G
Cancer Invest 2022 Feb;40(2):124-131. Epub 2021 Oct 21 doi: 10.1080/07357907.2021.1988962. PMID: 34601985
Prevalence and prognostic value of PD-L1 expression in molecular subtypes of metastatic large cell neuroendocrine carcinoma (LCNEC).
Hermans BCM, Derks JL, Thunnissen E, van Suylen RJ, den Bakker MA, Groen HJM, Smit EF, Damhuis RA, van den Broek EC, Stallinga CM, Roemen GM, Speel EJM, Dingemans AC; PALGA-group
Lung Cancer 2019 Apr;130:179-186. Epub 2019 Feb 21 doi: 10.1016/j.lungcan.2019.02.022. PMID: 30885341
Primary large cell neuroendocrine carcinoma of the skin: An under-recognized entity and a mimic of metastatic disease.
Lano IM, Rayson D, Arnason T, Walsh NMG
J Cutan Pathol 2018 Jan;45(1):54-58. Epub 2017 Nov 7 doi: 10.1111/cup.13051. PMID: 28960456
Metastatic large cell neuroendocrine carcinoma of the lung arising from the uterus: A pitfall in lung cancer diagnosis.
Ono K, Yokota NR, Yoshioka E, Noguchi A, Washimi K, Kawachi K, Miyagi Y, Kato H, Yokose T
Pathol Res Pract 2016 Jul;212(7):654-7. Epub 2016 Apr 2 doi: 10.1016/j.prp.2016.03.009. PMID: 27113439
Resection of right atrial metastatic large-cell neuroendocrine carcinoma.
Yap CH, Hair C, Foy S, Sewak S, Francis M, Kenny JF
Asian Cardiovasc Thorac Ann 2007 Jan;15(1):e20-2. doi: 10.1177/021849230701500131. PMID: 17244909

Therapy

Proton craniospinal irradiation with bevacizumab and pembrolizumab for leptomeningeal disease: a case report.
Webb MJ, Breen WG, Laack NN, Leventakos K, Campian JL, Sener U
CNS Oncol 2023 Sep 1;12(3):CNS101. Epub 2023 Jul 25 doi: 10.2217/cns-2023-0005. PMID: 37491842Free PMC Article
Platinum Doublet plus Atezolizumab as First-line Treatment in Metastatic Large Cell Neuroendocrine Carcinoma: A Single Institution Experience.
Vrontis K, Economidou SC, Fotopoulos G
Cancer Invest 2022 Feb;40(2):124-131. Epub 2021 Oct 21 doi: 10.1080/07357907.2021.1988962. PMID: 34601985
Parathyroid Hormone-Related Peptide (PTHrp)-Secreting Liver Metastatic Large-Cell Neuroendocrine Carcinoma of the Sigmoid Colon.
Zimmer V, Eltze E
Am J Med 2021 Sep;134(9):e494-e495. Epub 2021 May 11 doi: 10.1016/j.amjmed.2021.04.014. PMID: 33989607

Prognosis

Proton craniospinal irradiation with bevacizumab and pembrolizumab for leptomeningeal disease: a case report.
Webb MJ, Breen WG, Laack NN, Leventakos K, Campian JL, Sener U
CNS Oncol 2023 Sep 1;12(3):CNS101. Epub 2023 Jul 25 doi: 10.2217/cns-2023-0005. PMID: 37491842Free PMC Article
Prevalence and prognostic value of PD-L1 expression in molecular subtypes of metastatic large cell neuroendocrine carcinoma (LCNEC).
Hermans BCM, Derks JL, Thunnissen E, van Suylen RJ, den Bakker MA, Groen HJM, Smit EF, Damhuis RA, van den Broek EC, Stallinga CM, Roemen GM, Speel EJM, Dingemans AC; PALGA-group
Lung Cancer 2019 Apr;130:179-186. Epub 2019 Feb 21 doi: 10.1016/j.lungcan.2019.02.022. PMID: 30885341
Large cell neuroendocrine carcinoma of the lung presenting as pseudoachalasia: a case report.
Anaizi A, Rizvi-Toner A, Valestin J, Schey R
J Med Case Rep 2015 Mar 12;9:56. doi: 10.1186/s13256-015-0514-y. PMID: 25853982Free PMC Article

Clinical prediction guides

Platinum Doublet plus Atezolizumab as First-line Treatment in Metastatic Large Cell Neuroendocrine Carcinoma: A Single Institution Experience.
Vrontis K, Economidou SC, Fotopoulos G
Cancer Invest 2022 Feb;40(2):124-131. Epub 2021 Oct 21 doi: 10.1080/07357907.2021.1988962. PMID: 34601985
Prevalence and prognostic value of PD-L1 expression in molecular subtypes of metastatic large cell neuroendocrine carcinoma (LCNEC).
Hermans BCM, Derks JL, Thunnissen E, van Suylen RJ, den Bakker MA, Groen HJM, Smit EF, Damhuis RA, van den Broek EC, Stallinga CM, Roemen GM, Speel EJM, Dingemans AC; PALGA-group
Lung Cancer 2019 Apr;130:179-186. Epub 2019 Feb 21 doi: 10.1016/j.lungcan.2019.02.022. PMID: 30885341

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