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Increased urinary fucosylated oligosaccharide

MedGen UID:
1690802
•Concept ID:
C5139515
•
Finding
Synonym: Increased concentration of fucosylated oligosaccharides in urine
 
HPO: HP:0410350

Definition

An abnormal increase in the concentration of small fucosylated oligosaccharides in the urine. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVIncreased urinary fucosylated oligosaccharide

Recent clinical studies

Etiology

Increased alpha3-fucosylation of alpha1-acid glycoprotein in Type I diabetic patients is related to vascular function.
Poland DC, Schalkwijk CG, Stehouwer CD, Koeleman CA, van het Hof B, van Dijk W
Glycoconj J 2001 Mar;18(3):261-8. doi: 10.1023/a:1012412908983. PMID: 11602810
Binding specificity of a baby hamster kidney lectin for H type I and II chains, polylactosamine glycans, and appropriately glycosylated forms of laminin and fibronectin.
Sato S, Hughes RC
J Biol Chem 1992 Apr 5;267(10):6983-90. PMID: 1313027

Therapy

Tamm-Horsfall protein in humane urine: sex-dependent differences in the excretion and N-glycosylation pattern.
Mo B, Scharf B, Gutheil C, Letzel MC, Hensel A
Sci Rep 2023 Oct 19;13(1):17815. doi: 10.1038/s41598-023-44650-1. PMID: 37857738Free PMC Article

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