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Focal aware motor seizure

MedGen UID:: 1719715
•Concept ID:: C5397594
•: Disease or Syndrome

Synonyms:	Focal motor aware seizure; Focal onset aware motor onset epileptic seizure; Focal onset aware motor seizure; Focal-onset aware motor-onset epileptic seizure
SNOMED CT:	Focal onset aware motor onset epileptic seizure (82401000); Focal onset aware motor seizure (82401000); Focal aware motor seizure (82401000); Focal-onset aware motor-onset epileptic seizure (82401000)

HPO:	HP:0020217

Definition

A type of focal motor seizure in which awareness is retained throughout the seizure. [from HPO]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVFocal aware motor seizure

Disorder of nervous system
- Disorder of the central nervous system
  - Brain disorder
    - Epilepsy
      - Focal epilepsy
        Focal motor seizure
        Focal aware motor seizure
        Focal aware clonic seizure
        Focal aware hemiclonic seizure
        Focal aware hemifacial clonic seizure
        Focal aware hyperkinetic seizure
        Focal aware motor seizure with version
        Focal aware myoclonic seizure
        Focal aware tonic seizure

Conditions with this feature

Developmental and epileptic encephalopathy 112

MedGen UID:: 1845523
•Concept ID:: C5882700
•: Disease or Syndrome

Developmental and epileptic encephalopathy-112 (DEE112) is an autosomal dominant disorder characterized by a wide range of seizure types, including focal and generalized seizures. Cognitive outcomes range from normal intellect to profound impairment (summary by Happ et al., 2023). For a general phenotypic description and a discussion of genetic heterogeneity of DEE, see 308350.

See: Condition Record

Developmental and epileptic encephalopathy 112

Professional guidelines

PubMed

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Neurol Sci 2022 Nov;43(11):6381-6387. Epub 2022 Aug 5 doi: 10.1007/s10072-022-06299-y. PMID: 35930182 Free PMC Article

Testing awareness in focal seizures: Clinical practice and interpretation of current guidelines.

Contreras Ramirez V, Vaddiparti A, Blumenfeld H
Ann Clin Transl Neurol 2022 May;9(5):762-765. Epub 2022 Apr 29 doi: 10.1002/acn3.51552. PMID: 35485201 Free PMC Article

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Recent clinical studies

Etiology

Focal epilepsies: Update on diagnosis and classification.

Nascimento FA, Friedman D, Peters JM, Bensalem-Owen MK, Cendes F, Rampp S, Wirrell E, Blümcke I, Tatum W, Beniczky S
Epileptic Disord 2023 Feb;25(1):1-17. Epub 2023 Apr 17 doi: 10.1002/epd2.20045. PMID: 36938903

Randomized phase 2 study of adjunctive cenobamate in patients with uncontrolled focal seizures.

Chung SS, French JA, Kowalski J, Krauss GL, Lee SK, Maciejowski M, Rosenfeld WE, Sperling MR, Mizne S, Kamin M
Neurology 2020 Jun 2;94(22):e2311-e2322. Epub 2020 May 14 doi: 10.1212/WNL.0000000000009530. PMID: 32409485 Free PMC Article

Safety and efficacy of adjunctive cenobamate (YKP3089) in patients with uncontrolled focal seizures: a multicentre, double-blind, randomised, placebo-controlled, dose-response trial.

Krauss GL, Klein P, Brandt C, Lee SK, Milanov I, Milovanovic M, Steinhoff BJ, Kamin M
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Diagnosis

Focal epilepsies: Update on diagnosis and classification.

Epilepsy Overview and Revised Classification of Seizures and Epilepsies.

Pack AM
Continuum (Minneap Minn) 2019 Apr;25(2):306-321. doi: 10.1212/CON.0000000000000707. PMID: 30921011

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Operational classification of seizure types by the International League Against Epilepsy: Position Paper of the ILAE Commission for Classification and Terminology.

Fisher RS, Cross JH, French JA, Higurashi N, Hirsch E, Jansen FE, Lagae L, Moshé SL, Peltola J, Roulet Perez E, Scheffer IE, Zuberi SM
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Familial cavernous angiomas.

Bicknell JM, Carlow TJ, Kornfeld M, Stovring J, Turner P
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Therapy

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GAD65 Antibody-Associated Epilepsy.

Valinčiūtė J, Jucevičiūtė N, Balnytė R, Jurkevičienė G, Gelžinienė G
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CASPR2-IgG-associated autoimmune seizures.

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Epilepsia 2022 Mar;63(3):709-722. Epub 2022 Jan 15 doi: 10.1111/epi.17164. PMID: 35032032

Randomized phase 2 study of adjunctive cenobamate in patients with uncontrolled focal seizures.

Safety and efficacy of adjunctive cenobamate (YKP3089) in patients with uncontrolled focal seizures: a multicentre, double-blind, randomised, placebo-controlled, dose-response trial.

Krauss GL, Klein P, Brandt C, Lee SK, Milanov I, Milovanovic M, Steinhoff BJ, Kamin M
Lancet Neurol 2020 Jan;19(1):38-48. Epub 2019 Nov 14 doi: 10.1016/S1474-4422(19)30399-0. PMID: 31734103

See all (169)

Prognosis

GAD65 Antibody-Associated Epilepsy.

Valinčiūtė J, Jucevičiūtė N, Balnytė R, Jurkevičienė G, Gelžinienė G
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CASPR2-IgG-associated autoimmune seizures.

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J Neuroimaging 2019 May;29(3):287-308. Epub 2019 Mar 28 doi: 10.1111/jon.12614. PMID: 30920080

Cerebral venous thrombosis.

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Recent systematic reviews

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Focal aware motor seizure

Definition

Term Hierarchy

Conditions with this feature

Professional guidelines

PubMed

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

Recent systematic reviews

Supplemental Content

Table of contents

Clinical resources

Practice guidelines

Consumer resources

Reviews

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