U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Lacrimal System Carcinoma

MedGen UID:
1781723
•Concept ID:
C5428721
•
Neoplastic Process
Synonym: Lacrimal Apparatus Carcinoma

Definition

A carcinoma that arises from the lacrimal gland or the lacrimal drainage system. [from NCI]

Professional guidelines

PubMed

Clinical management and outcomes of lacrimal sac squamous cell carcinoma.
Song X, Wang S, Wang J, Wang W, Wang S, Yang G, Li J, Zhu Y, Chen F, Zhu W
Head Neck 2019 Apr;41(4):974-981. Epub 2019 Jan 10 doi: 10.1002/hed.25529. PMID: 30629760
Evaluation and Management of Chemotherapy-Induced Epiphora, Punctal and Canalicular Stenosis, and Nasolacrimal Duct Obstruction.
Mansur C, Pfeiffer ML, Esmaeli B
Ophthalmic Plast Reconstr Surg 2017 Jan/Feb;33(1):9-12. doi: 10.1097/IOP.0000000000000745. PMID: 27429222
Current treatment of lacrimal gland carcinoma.
Woo KI, Kim YD, Sa HS, Esmaeli B
Curr Opin Ophthalmol 2016 Sep;27(5):449-56. doi: 10.1097/ICU.0000000000000301. PMID: 27273588

Recent clinical studies

Etiology

Carcinomas of the lacrimal drainage system.
Ramberg I, Toft PB, Heegaard S
Surv Ophthalmol 2020 Nov-Dec;65(6):691-707. Epub 2020 Apr 15 doi: 10.1016/j.survophthal.2020.04.001. PMID: 32304675
Lacrimal Sac Sebaceous Carcinoma.
Vahdani K, Coupland SE, Ashdown ME, Garrott H, Ford R
Ophthalmic Plast Reconstr Surg 2019 Jul/Aug;35(4):e89-e91. doi: 10.1097/IOP.0000000000001386. PMID: 30921057
Overview of benign and malignant lacrimal gland tumors.
Gündüz AK, Yeşiltaş YS, Shields CL
Curr Opin Ophthalmol 2018 Sep;29(5):458-468. doi: 10.1097/ICU.0000000000000515. PMID: 30028745
Current treatment of lacrimal gland carcinoma.
Woo KI, Kim YD, Sa HS, Esmaeli B
Curr Opin Ophthalmol 2016 Sep;27(5):449-56. doi: 10.1097/ICU.0000000000000301. PMID: 27273588
Tumors of the lacrimal drainage system.
Heindl LM, Jünemann AG, Kruse FE, Holbach LM
Orbit 2010 Oct;29(5):298-306. doi: 10.3109/01676830.2010.492887. PMID: 20958177

Diagnosis

Human Papillomavirus Related Neoplasia of the Ocular Adnexa.
Ramberg I, Heegaard S
Viruses 2021 Aug 2;13(8) doi: 10.3390/v13081522. PMID: 34452388Free PMC Article
Carcinomas of the lacrimal drainage system.
Ramberg I, Toft PB, Heegaard S
Surv Ophthalmol 2020 Nov-Dec;65(6):691-707. Epub 2020 Apr 15 doi: 10.1016/j.survophthal.2020.04.001. PMID: 32304675
Lacrimal Sac Sebaceous Carcinoma.
Vahdani K, Coupland SE, Ashdown ME, Garrott H, Ford R
Ophthalmic Plast Reconstr Surg 2019 Jul/Aug;35(4):e89-e91. doi: 10.1097/IOP.0000000000001386. PMID: 30921057
Overview of benign and malignant lacrimal gland tumors.
Gündüz AK, Yeşiltaş YS, Shields CL
Curr Opin Ophthalmol 2018 Sep;29(5):458-468. doi: 10.1097/ICU.0000000000000515. PMID: 30028745
Tumors of the lacrimal gland.
von Holstein SL, Rasmussen PK, Heegaard S
Semin Diagn Pathol 2016 May;33(3):156-63. Epub 2015 Oct 9 doi: 10.1053/j.semdp.2015.10.002. PMID: 26849904

Therapy

Visual outcome and ocular complications in patients with lacrimal gland carcinoma after eye-sparing surgery and adjuvant radiation therapy.
Zhao Z, Frank SJ, Ning J, Zhao J, Jiang X, Wang XA, Schefler AC, Hanna E, Moreno A, Gunn B, Ferrarotto R, Esmaeli B
Br J Ophthalmol 2023 Nov 22;107(12):1914-1919. doi: 10.1136/bjo-2022-321889. PMID: 36229179Free PMC Article
Treatment outcomes after definitive radio(chemo)therapy for 17 lacrimal sac squamous cell carcinoma.
Song X, He H, Zhu Y, Wang S, Wang J, Wang W, Li Y
Br J Radiol 2020 Nov 1;93(1115):20190633. Epub 2020 Oct 6 doi: 10.1259/bjr.20190633. PMID: 32970475Free PMC Article
Intra-arterial Chemotherapy for Lacrimal Gland Adenoid Cystic Carcinoma.
Zhang M, Fathy C, Breazzano MP, Hollar M, Barahimi B
Int Ophthalmol Clin 2017 Winter;57(1):143-152. doi: 10.1097/IIO.0000000000000158. PMID: 27898620
Evaluation and Management of Chemotherapy-Induced Epiphora, Punctal and Canalicular Stenosis, and Nasolacrimal Duct Obstruction.
Mansur C, Pfeiffer ML, Esmaeli B
Ophthalmic Plast Reconstr Surg 2017 Jan/Feb;33(1):9-12. doi: 10.1097/IOP.0000000000000745. PMID: 27429222
Intermediate and long-term adverse effects of radioiodine therapy for differentiated thyroid carcinoma--a systematic review.
Clement SC, Peeters RP, Ronckers CM, Links TP, van den Heuvel-Eibrink MM, Nieveen van Dijkum EJ, van Rijn RR, van der Pal HJ, Neggers SJ, Kremer LC, van Eck-Smit BL, van Santen HM
Cancer Treat Rev 2015 Dec;41(10):925-34. Epub 2015 Sep 10 doi: 10.1016/j.ctrv.2015.09.001. PMID: 26421813

Prognosis

Clinical management and outcomes of lacrimal sac squamous cell carcinoma.
Song X, Wang S, Wang J, Wang W, Wang S, Yang G, Li J, Zhu Y, Chen F, Zhu W
Head Neck 2019 Apr;41(4):974-981. Epub 2019 Jan 10 doi: 10.1002/hed.25529. PMID: 30629760
Overview of benign and malignant lacrimal gland tumors.
Gündüz AK, Yeşiltaş YS, Shields CL
Curr Opin Ophthalmol 2018 Sep;29(5):458-468. doi: 10.1097/ICU.0000000000000515. PMID: 30028745
An Update on Tumors of the Lacrimal Gland.
Andreasen S, Esmaeli B, Holstein SL, Mikkelsen LH, Rasmussen PK, Heegaard S
Asia Pac J Ophthalmol (Phila) 2017 Mar-Apr;6(2):159-172. doi: 10.22608/APO.201707. PMID: 28399336
Tumors of the lacrimal gland.
von Holstein SL, Rasmussen PK, Heegaard S
Semin Diagn Pathol 2016 May;33(3):156-63. Epub 2015 Oct 9 doi: 10.1053/j.semdp.2015.10.002. PMID: 26849904
Tumors of the lacrimal drainage system.
Heindl LM, Jünemann AG, Kruse FE, Holbach LM
Orbit 2010 Oct;29(5):298-306. doi: 10.3109/01676830.2010.492887. PMID: 20958177

Clinical prediction guides

Adenoid Cystic Carcinoma from the salivary and lacrimal glands and the breast: Different clinical outcomes to the same tumor.
Emerick C, Mariano FV, Vargas PA, Nör JE, Squarize CH, Castilho RM
Crit Rev Oncol Hematol 2022 Nov;179:103792. Epub 2022 Aug 13 doi: 10.1016/j.critrevonc.2022.103792. PMID: 35973662
Human Papillomavirus Related Neoplasia of the Ocular Adnexa.
Ramberg I, Heegaard S
Viruses 2021 Aug 2;13(8) doi: 10.3390/v13081522. PMID: 34452388Free PMC Article
Mohs Surgery for Periocular Tumors.
Monheit G, Hrynewycz K
Dermatol Surg 2019 Dec;45 Suppl 2:S70-S78. doi: 10.1097/DSS.0000000000002254. PMID: 31764293
Clinical management and outcomes of lacrimal sac squamous cell carcinoma.
Song X, Wang S, Wang J, Wang W, Wang S, Yang G, Li J, Zhu Y, Chen F, Zhu W
Head Neck 2019 Apr;41(4):974-981. Epub 2019 Jan 10 doi: 10.1002/hed.25529. PMID: 30629760
Schneiderian papillomas and carcinomas: a review.
Batsakis JG, Suarez P
Adv Anat Pathol 2001 Mar;8(2):53-64. doi: 10.1097/00125480-200103000-00001. PMID: 11236954

Recent systematic reviews

Effectiveness of Nasolacrimal SCC Treatments and Promising Role of Chemo-Induction: A Case Report and Systematic Review.
Alsavaf MB, Abouammo MD, Bhuskute GS, Sun S, Issa M, Seim NB, VanKoevering KK, Bhateja P, Bonomi M, Carrau RL
Laryngoscope 2024 Sep;134(9):3892-3902. Epub 2024 Apr 23 doi: 10.1002/lary.31426. PMID: 38651346
Holding back the tears: is there a role for marsupialisation?
Chiu SJ, Currie ZI, Tan JH
BMJ Open Ophthalmol 2022 Aug;7(1) doi: 10.1136/bmjophth-2022-000985. PMID: 36161857Free PMC Article
Ectopic Lacrimal Gland Tissue: A Systematic Review.
Nagendran S, Alsamnan M, Strianese D, Malhotra R
Ophthalmic Plast Reconstr Surg 2020 Nov/Dec;36(6):540-544. doi: 10.1097/IOP.0000000000001621. PMID: 32205779
A systematic review of sinonasal oncocytomas and oncocytic carcinomas: Diagnosis, management, and technical considerations.
Hodzic Z, Rowan NR, Kashiwazaki R, Willson TJ, Wang EW, Lee SE
Int Forum Allergy Rhinol 2017 May;7(5):514-524. Epub 2017 Jan 16 doi: 10.1002/alr.21902. PMID: 28092140
Intermediate and long-term adverse effects of radioiodine therapy for differentiated thyroid carcinoma--a systematic review.
Clement SC, Peeters RP, Ronckers CM, Links TP, van den Heuvel-Eibrink MM, Nieveen van Dijkum EJ, van Rijn RR, van der Pal HJ, Neggers SJ, Kremer LC, van Eck-Smit BL, van Santen HM
Cancer Treat Rev 2015 Dec;41(10):925-34. Epub 2015 Sep 10 doi: 10.1016/j.ctrv.2015.09.001. PMID: 26421813

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...