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Mixed Trophoblastic Tumor

MedGen UID:
1792954
•Concept ID:
C5556513
•
Neoplastic Process

Definition

A gestational trophoblastic tumor characterized by the presence of two or three histological types of gestational trophoblastic tumor, including choriocarcinoma, placental site trophoblastic tumor, and epithelioid trophoblastic tumor. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMixed Trophoblastic Tumor

Professional guidelines

PubMed

Treatment outcomes and risk factors of patients with intracranial germ cell tumour with choriocarcinoma element or β-HCG level higher than 500 IU/L.
Feng J, Zhang J, Chen L, Li C, Liu W, Chen H, Qiu X, Li B
J Neurooncol 2024 Jan;166(2):331-339. Epub 2024 Jan 18 doi: 10.1007/s11060-024-04565-x. PMID: 38236548
Primary Mediastinal Nonseminomas: A Population-Based Surveillance, Epidemiology, and End Results Analysis.
Yang X, Zhao K, Mei J, Wei S, Xia L, Pu Y, Liu L
J Surg Res 2021 Nov;267:25-36. Epub 2021 Jun 11 doi: 10.1016/j.jss.2021.04.022. PMID: 34126390
Differential diagnosis of testicular mass by cytological examination of seminal fluid collected by ejaculation or prostatic massage.
Yu DS, Wang J, Chang SY, Ma CP
Eur Urol 1990;18(3):193-6. doi: 10.1159/000463907. PMID: 2261930

Recent clinical studies

Diagnosis

Mixed Gestational Trophoblastic Tumors-Challenging Clinicopathological Presentations.
Niu N, Buza N, Hui P
Int J Gynecol Pathol 2025 Jan 1;44(1):42-48. Epub 2024 Jun 26 doi: 10.1097/PGP.0000000000001044. PMID: 38959396
Pathology of Gestational Trophoblastic Disease (GTD).
Kaur B
Hematol Oncol Clin North Am 2024 Dec;38(6):1191-1217. Epub 2024 Sep 24 doi: 10.1016/j.hoc.2024.08.017. PMID: 39322461
Placental site trophoblastic tumor and choriocarcinoma: an unusual presentation.
Gari A
BMC Res Notes 2015 Nov 23;8:703. doi: 10.1186/s13104-015-1693-8. PMID: 26597227Free PMC Article
Placental-site trophoblastic tumors: a case of resistant pulmonary metastasis.
Cole ME, Broaddus R, Thaker P, Landen C, Freedman RS
Nat Clin Pract Oncol 2008 Mar;5(3):171-5. doi: 10.1038/ncponc1042. PMID: 18227827

Prognosis

Mixed Gestational Trophoblastic Tumors-Challenging Clinicopathological Presentations.
Niu N, Buza N, Hui P
Int J Gynecol Pathol 2025 Jan 1;44(1):42-48. Epub 2024 Jun 26 doi: 10.1097/PGP.0000000000001044. PMID: 38959396

Supplemental Content

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    Practice guidelines

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