Full Report

Format

Full Report
Summary (Text)
Summary (XML)

Send to:

Choose Destination

File
Clipboard
Collections

Gestational trophoblastic neoplasm

MedGen UID:: 210107
•Concept ID:: C1135868
•: Neoplastic Process

Synonyms:	Gestational Trophoblastic Neoplasia; Gestational Trophoblastic Neoplasm; Gestational Trophoblastic Neoplasms; Neoplasia, Gestational Trophoblastic; Neoplasm, Gestational Trophoblastic; Neoplasms, Gestational Trophoblastic; Trophoblastic Neoplasia, Gestational; Trophoblastic Neoplasm, Gestational; Trophoblastic Neoplasms, Gestational
SNOMED CT:	Persistent trophoblastic disease (609519004); Gestational trophoblastic neoplasia (609517002); Persistent gestational trophoblastic disease (609519004); Gestational trophoblastic neoplasia (609519004)
Modes of inheritance:	Not genetically inherited MedGen UID: 988794 •Concept ID: CN307044 • Finding Source: Orphanet clinical entity without genetic inheritance. See: This record Not genetically inherited (Orphanet)

Monarch Initiative:	MONDO:0018944
Orphanet:	ORPHA59305

Definition

Disorder characterised by abnormal proliferation of trophoblasts during pregnancy, of a type which is invasive or metastatic. [from SNOMEDCT_US]

Term Hierarchy

GTR
MeSH
Orphanet

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVGestational trophoblastic neoplasm

Disease
- Disorder by Site
  - Disorder of the genitourinary system
    - Reproductive system disorder
      - Female reproductive system disorder
        Female reproductive system neoplasm
        Gestational trophoblastic neoplasm
        Epithelioid trophoblastic tumor
        Gestational choriocarcinoma
        Fallopian tube gestational choriocarcinoma
        Gestational ovarian choriocarcinoma
        Placental choriocarcinoma
        Uterine corpus choriocarcinoma
        Gestational Trophoblastic Tumor by AJCC v7 Stage
        Stage I Gestational Trophoblastic Tumor AJCC v7
        Stage IA Gestational Trophoblastic Tumor AJCC v7
        Stage IB Gestational Trophoblastic Tumor AJCC v7
        Stage II Gestational Trophoblastic Tumor AJCC v7
        Stage IIA Gestational Trophoblastic Tumor AJCC v7
        Stage IIB Gestational Trophoblastic Tumor AJCC v7
        Stage III Gestational Trophoblastic Tumor AJCC v7
        Stage IIIA Gestational Trophoblastic Tumor AJCC v7
        Stage IIIB Gestational Trophoblastic Tumor AJCC v7
        Stage IV Gestational Trophoblastic Tumor AJCC v7
        Stage IVA Gestational Trophoblastic Tumor AJCC v7
        Stage IVB Gestational Trophoblastic Tumor AJCC v7
        Good Prognosis Metastatic Gestational Trophoblastic Tumor
        Invasive hydatidiform mole
        Metastatic Hydatidiform Mole
        Mixed Trophoblastic Tumor
        Non-Metastatic Gestational Trophoblastic Tumor
        Placental site trophoblastic tumor
        Poor Prognosis Metastatic Gestational Trophoblastic Tumor
        Recurrent Gestational Trophoblastic Tumor

Follow this link to review classifications for Gestational trophoblastic neoplasm in Orphanet.

Professional guidelines

PubMed

Assessment of risk factors associated with post-molar gestational trophoblastic neoplasia: a retrospective cohort.

Piazzetta SR, Hoch KA, Benetti-Pinto CL, Yela DA
Rev Bras Ginecol Obstet 2024;46 Epub 2024 Oct 23 doi: 10.61622/rbgo/2024rbgo83. PMID: 39530069 Free PMC Article

Analysis of the Outcome of Treatment of Brain Metastases from Malignant Trophoblastic Tumours and Risk Factors for Prognosis during Pregnancy.

Wang A, Zhang H
Contrast Media Mol Imaging 2022;2022:3932460. Epub 2022 Aug 11 doi: 10.1155/2022/3932460. PMID: 36017013 Free PMC Article

Treatment results of the second-line chemotherapy regimen for patients with low-risk gestational trophoblastic neoplasia treated with 5-day methotrexate and 5-day etoposide.

Kanno T, Matsui H, Akizawa Y, Usui H, Shozu M
J Gynecol Oncol 2018 Nov;29(6):e89. doi: 10.3802/jgo.2018.29.e89. PMID: 30207097 Free PMC Article

See all (4)

Curated

NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®) Gestational Trophoblastic Neoplasia, 2023

Recent clinical studies

Etiology

Gestational trophoblastic neoplasm: Patient outcomes and clinical pearls from a multidisciplinary referral center.

Liu YL, Praiss AM, Chiang S, Devereaux K, Huang J, Rizzuto G, Al-Rawi D, Weigelt B, Jewell E, Abu-Rustum NR, Aghajanian C
Gynecol Oncol 2025 Jan;192:171-177. Epub 2024 Dec 13 doi: 10.1016/j.ygyno.2024.12.009. PMID: 39674133 Free PMC Article

A Phase II Basket Trial of Dual Anti-CTLA-4 and Anti-PD-1 Blockade in Rare Tumors (DART SWOG 1609 Cohort 47) in Patients with Gestational Trophoblastic Neoplasia.

Patel SP, Othus M, Chae YK, Dennis MJ, Gordon S, Mutch D, Samlowski W, Robinson WRR, Sharon E, Ryan C, Lopez G, Plets M, Blanke C, Kurzrock R
Clin Cancer Res 2024 Jan 5;30(1):33-38. doi: 10.1158/1078-0432.CCR-23-2293. PMID: 37882676 Free PMC Article

Gestational trophoblastic neoplasia: Novelties and challenges.

Silva ALMD, Monteiro KDN, Sun SY, Borbely AU
Placenta 2021 Dec;116:38-42. Epub 2021 Feb 25 doi: 10.1016/j.placenta.2021.02.013. PMID: 33685753

Gestational trophoblastic disease: an overview.

Monchek R, Wiedaseck S
J Midwifery Womens Health 2012 May-Jun;57(3):255-9. Epub 2012 May 15 doi: 10.1111/j.1542-2011.2012.00177.x. PMID: 22587615

Successful treatment of a patient with gestational trophoblastic neoplasm metastatic to the colon.

Ghaemmaghami F, Sohrabvand F, Ayatollahi H, Modarres M
J Obstet Gynaecol 2005 Oct;25(7):735-7. doi: 10.1080/01443610500307748. PMID: 16263566

See all (40)

Diagnosis

Atypical presentation of a rare gestational trophoblastic neoplasm: A case report.

Aamir FB, Raza Raja MH, Ahmad Zaidi SM, Noorali AA, Pervez MB, Fatimi SH
J Pak Med Assoc 2022 Jun;72(6):1260-1262. doi: 10.47391/JPMA.3203. PMID: 35751357

Gestational trophoblastic neoplasia: Novelties and challenges.

Silva ALMD, Monteiro KDN, Sun SY, Borbely AU
Placenta 2021 Dec;116:38-42. Epub 2021 Feb 25 doi: 10.1016/j.placenta.2021.02.013. PMID: 33685753

Gestational trophoblastic disease: an overview.

Monchek R, Wiedaseck S
J Midwifery Womens Health 2012 May-Jun;57(3):255-9. Epub 2012 May 15 doi: 10.1111/j.1542-2011.2012.00177.x. PMID: 22587615

Patients with presenting unusual manifestations with gestational trophoblastic neoplasm: case series and review of literatures.

Ashraf-Ganjooei T, Ghaemmaghami F
Arch Gynecol Obstet 2008 May;277(5):465-70. Epub 2007 Oct 17 doi: 10.1007/s00404-007-0469-3. PMID: 17940785

Placental site trophoblastic tumor.

Behtash N, Karimi Zarchi M
J Cancer Res Clin Oncol 2008 Jan;134(1):1-6. Epub 2007 Aug 16 doi: 10.1007/s00432-007-0208-y. PMID: 17701427

See all (50)

Therapy

Gestational trophoblastic neoplasm: Patient outcomes and clinical pearls from a multidisciplinary referral center.

A Phase II Basket Trial of Dual Anti-CTLA-4 and Anti-PD-1 Blockade in Rare Tumors (DART SWOG 1609 Cohort 47) in Patients with Gestational Trophoblastic Neoplasia.

The efficacy evaluation of initial chemotherapy for high-risk gestational trophoblastic neoplasm.

Li Y, Chen D, Yu H, Xia R, Zhang X, Zheng W
Curr Probl Cancer 2022 Jun;46(3):100861. Epub 2022 Mar 29 doi: 10.1016/j.currproblcancer.2022.100861. PMID: 35421635

Uterine rupture and shock: an unusual presentation of gestational trophoblastic neoplasm.

Mohamed Aymen F, Slim K, Khaled N
Am J Obstet Gynecol 2021 Aug;225(2):191. Epub 2021 Mar 10 doi: 10.1016/j.ajog.2021.03.009. PMID: 33713681

Successful treatment of a patient with gestational trophoblastic neoplasm metastatic to the colon.

Ghaemmaghami F, Sohrabvand F, Ayatollahi H, Modarres M
J Obstet Gynaecol 2005 Oct;25(7):735-7. doi: 10.1080/01443610500307748. PMID: 16263566

See all (18)

Prognosis

Claudin-6 enhances the malignant progression of gestational trophoblastic neoplasm by promoting proliferation and metastasis.

Wu Q, Peng M, Lv C, Chen L, Mao X, Lin T, Sun P, Wang Y
Clin Transl Oncol 2023 Apr;25(4):1114-1123. Epub 2022 Dec 5 doi: 10.1007/s12094-022-03021-4. PMID: 36471225

Atypical presentation of a rare gestational trophoblastic neoplasm: A case report.

Aamir FB, Raza Raja MH, Ahmad Zaidi SM, Noorali AA, Pervez MB, Fatimi SH
J Pak Med Assoc 2022 Jun;72(6):1260-1262. doi: 10.47391/JPMA.3203. PMID: 35751357

Gestational trophoblastic neoplasia: Novelties and challenges.

Silva ALMD, Monteiro KDN, Sun SY, Borbely AU
Placenta 2021 Dec;116:38-42. Epub 2021 Feb 25 doi: 10.1016/j.placenta.2021.02.013. PMID: 33685753

Diagnosis and treatment of placental site trophoblastic tumor.

Huang F, Zheng W, Liang Q, Yin T
Int J Clin Exp Pathol 2013;6(7):1448-51. Epub 2013 Jun 15 PMID: 23826431 Free PMC Article

Successful treatment of a patient with gestational trophoblastic neoplasm metastatic to the colon.

Ghaemmaghami F, Sohrabvand F, Ayatollahi H, Modarres M
J Obstet Gynaecol 2005 Oct;25(7):735-7. doi: 10.1080/01443610500307748. PMID: 16263566

See all (37)

Clinical prediction guides

Gestational trophoblastic neoplasm: Patient outcomes and clinical pearls from a multidisciplinary referral center.

A Phase II Basket Trial of Dual Anti-CTLA-4 and Anti-PD-1 Blockade in Rare Tumors (DART SWOG 1609 Cohort 47) in Patients with Gestational Trophoblastic Neoplasia.

Gestational trophoblastic neoplasia: Novelties and challenges.

Silva ALMD, Monteiro KDN, Sun SY, Borbely AU
Placenta 2021 Dec;116:38-42. Epub 2021 Feb 25 doi: 10.1016/j.placenta.2021.02.013. PMID: 33685753

Differential expression of SALL4 in CTCs derived from hydatidiform moles and gestational trophoblastic neoplasms.

Xu D, Feng F, Pei Y, Zhang Y, Wu Y, Guo Y, Cui W
Am J Reprod Immunol 2020 May;83(5):e13233. Epub 2020 Apr 16 doi: 10.1111/aji.13233. PMID: 32187420

Role of salvage therapy in chemo resistant or recurrent high-risk gestational trophoblastic neoplasm.

Anantharaju AA, Pallavi VR, Bafna UD, Rathod PS, R VC, K S, Kundargi R
Int J Gynecol Cancer 2019 Mar;29(3):547-553. Epub 2019 Jan 29 doi: 10.1136/ijgc-2018-000050. PMID: 30700567

See all (20)

MedGen

National Center for Biotechnology Information

Send to:

Gestational trophoblastic neoplasm

Definition

Term Hierarchy

Professional guidelines

PubMed

Curated

NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®) Gestational Trophoblastic Neoplasia, 2023

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

Supplemental Content

Table of contents

Clinical resources

Practice guidelines

Curated

Consumer resources

Reviews

Related information

Recent activity