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Ovarian adenocarcinoma

MedGen UID:
181757
•Concept ID:
C0948216
•
Neoplastic Process
Synonyms: Adenocarcinoma of Ovary; adenocarcinoma of ovary; Adenocarcinoma of ovary; Adenocarcinoma of the Ovary; adenocarcinoma of the ovary; Ovarian Adenocarcinoma; ovarian adenocarcinoma; ovary adenocarcinoma
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
•Concept ID:
CN307044
•
Finding
Source: Orphanet
clinical entity without genetic inheritance.
See: This record
Not genetically inherited (Orphanet)
 
Monarch Initiative: MONDO:0002752
Orphanet: ORPHA213504

Definition

An adenocarcinoma that arises from the ovary. It is the most common type of ovarian carcinoma. It includes the serous adenocarcinoma, mucinous adenocarcinoma, clear cell adenocarcinoma, and endometrioid adenocarcinoma. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVOvarian adenocarcinoma
Follow this link to review classifications for Ovarian adenocarcinoma in Orphanet.

Professional guidelines

PubMed

HSF1 Pathway Inhibitor Clinical Candidate (CCT361814/NXP800) Developed from a Phenotypic Screen as a Potential Treatment for Refractory Ovarian Cancer and Other Malignancies.
Pasqua AE, Sharp SY, Chessum NEA, Hayes A, Pellegrino L, Tucker MJ, Miah A, Wilding B, Evans LE, Rye CS, Mok NY, Liu M, Henley AT, Gowan S, De Billy E, Te Poele R, Powers M, Eccles SA, Clarke PA, Raynaud FI, Workman P, Jones K, Cheeseman MD
J Med Chem 2023 Apr 27;66(8):5907-5936. Epub 2023 Apr 5 doi: 10.1021/acs.jmedchem.3c00156. PMID: 37017629Free PMC Article
Tumor-Treating Fields: A fourth modality in cancer treatment, new practice updates.
Arvind R, Chandana SR, Borad MJ, Pennington D, Mody K, Babiker H
Crit Rev Oncol Hematol 2021 Dec;168:103535. Epub 2021 Nov 19 doi: 10.1016/j.critrevonc.2021.103535. PMID: 34808377
Oncolytic adenovirus Ad5/3-delta24 and chemotherapy for treatment of orthotopic ovarian cancer.
Raki M, Särkioja M, Desmond RA, Chen DT, Bützow R, Hemminki A, Kanerva A
Gynecol Oncol 2008 Jan;108(1):166-72. Epub 2007 Oct 22 doi: 10.1016/j.ygyno.2007.09.013. PMID: 17950450

Recent clinical studies

Etiology

Extended Pelvic Resections as Part of Secondary Cytoreduction for Relapsed Ovarian Adenocarcinoma.
Bacalbasa N, Balescu I, Dima S, Vilcu M, Brezean I
In Vivo 2020 Jan-Feb;34(1):397-400. doi: 10.21873/invivo.11787. PMID: 31882505Free PMC Article
The Importance of Appendectomy in Surgery for Mucinous Adenocarcinoma of the Ovary.
Rosendahl M, Haueberg Oester LA, Høgdall CK
Int J Gynecol Cancer 2017 Mar;27(3):430-436. doi: 10.1097/IGC.0000000000000910. PMID: 28060142
Cryotherapy for liver metastases.
Bala MM, Riemsma RP, Wolff R, Kleijnen J
Cochrane Database Syst Rev 2013 Jun 5;(6):CD009058. doi: 10.1002/14651858.CD009058.pub2. PMID: 23740609
Androgens stimulate telomerase expression, activity and phosphorylation in ovarian adenocarcinoma cells.
Nourbakhsh M, Golestani A, Zahrai M, Modarressi MH, Malekpour Z, Karami-Tehrani F
Mol Cell Endocrinol 2010 Dec 15;330(1-2):10-6. Epub 2010 Jul 27 doi: 10.1016/j.mce.2010.07.021. PMID: 20673788
The inhibins and ovarian cancer.
Burger HG, Fuller PJ, Chu S, Mamers P, Drummond A, Susil B, Neva P, Robertson DM
Mol Cell Endocrinol 2001 Jun 30;180(1-2):145-8. doi: 10.1016/s0303-7207(01)00519-6. PMID: 11451584

Diagnosis

Paraneoplastic movement disorders.
McKeon A, Tracy J
Handb Clin Neurol 2024;200:211-227. doi: 10.1016/B978-0-12-823912-4.00004-9. PMID: 38494279
Cellular Functions of Deubiquitinating Enzymes in Ovarian Adenocarcinoma.
Min Y, Park HB, Baek KH, Hwang S
Genes (Basel) 2023 Apr 9;14(4) doi: 10.3390/genes14040886. PMID: 37107644Free PMC Article
Sister Mary Joseph's nodule.
Grech A, Abela R
J R Coll Physicians Edinb 2020 Jun;50(2):162-163. doi: 10.4997/JRCPE.2020.218. PMID: 32568290
Synchronous Cervical Adenocarcinoma and Ovarian Serous Adenocarcinoma-A Case Report and Literature Review.
Bacalbasa N, Balescu IC, Diaconu C, Dima S, Iliescu L, Vilcu M, Filipescu A, Halmaciu I, Cretoiu D, Brezean I
Medicina (Kaunas) 2020 Mar 29;56(4) doi: 10.3390/medicina56040152. PMID: 32235322Free PMC Article
Recent advances in immunohistochemistry in the diagnosis of ovarian neoplasms.
McCluggage WG
J Clin Pathol 2000 May;53(5):327-34. doi: 10.1136/jcp.53.5.327. PMID: 10889812Free PMC Article

Therapy

The PARP1 Inhibitor AZD5305 Impairs Ovarian Adenocarcinoma Progression and Visceral Metastases in Patient-derived Xenografts Alone and in Combination with Carboplatin.
Dellavedova G, Decio A, Formenti L, Albertella MR, Wilson J, Staniszewska AD, Leo E, Giavazzi R, Ghilardi C, Bani MR
Cancer Res Commun 2023 Mar;3(3):489-500. Epub 2023 Mar 27 doi: 10.1158/2767-9764.CRC-22-0423. PMID: 36994441Free PMC Article
Deciphering serous ovarian carcinoma histopathology and platinum response by convolutional neural networks.
Yu KH, Hu V, Wang F, Matulonis UA, Mutter GL, Golden JA, Kohane IS
BMC Med 2020 Aug 18;18(1):236. doi: 10.1186/s12916-020-01684-w. PMID: 32807164Free PMC Article
MCL1 regulates cell death, tumor growth and chemosensitivity to sabutoclax in ovarian adenocarcinoma.
Li C, Song Y, Li P
Cell Tissue Res 2020 Mar;379(3):625-633. Epub 2019 Nov 21 doi: 10.1007/s00441-019-03105-8. PMID: 31754782
Ovarian cancer microenvironment: implications for cancer dissemination and chemoresistance acquisition.
Thibault B, Castells M, Delord JP, Couderc B
Cancer Metastasis Rev 2014 Mar;33(1):17-39. doi: 10.1007/s10555-013-9456-2. PMID: 24357056
Cryotherapy for liver metastases.
Bala MM, Riemsma RP, Wolff R, Kleijnen J
Cochrane Database Syst Rev 2013 Jun 5;(6):CD009058. doi: 10.1002/14651858.CD009058.pub2. PMID: 23740609

Prognosis

Paraneoplastic movement disorders.
McKeon A, Tracy J
Handb Clin Neurol 2024;200:211-227. doi: 10.1016/B978-0-12-823912-4.00004-9. PMID: 38494279
Prognostic gene profiles in the tumor microenvironment of ovarian serous adenocarcinoma.
Tian R, Zhao G, Zhou A, Li H, Cao B, Guo S
Front Biosci (Landmark Ed) 2021 Jan 1;26(4):692-705. doi: 10.2741/4913. PMID: 33049689
Deciphering serous ovarian carcinoma histopathology and platinum response by convolutional neural networks.
Yu KH, Hu V, Wang F, Matulonis UA, Mutter GL, Golden JA, Kohane IS
BMC Med 2020 Aug 18;18(1):236. doi: 10.1186/s12916-020-01684-w. PMID: 32807164Free PMC Article
Ovarian cancer microenvironment: implications for cancer dissemination and chemoresistance acquisition.
Thibault B, Castells M, Delord JP, Couderc B
Cancer Metastasis Rev 2014 Mar;33(1):17-39. doi: 10.1007/s10555-013-9456-2. PMID: 24357056
Axl and prostasin are biomarkers for prognosis of ovarian adenocarcinoma.
Chen PX, Li QY, Yang Z
Ann Diagn Pathol 2013 Oct;17(5):425-9. Epub 2013 May 23 doi: 10.1016/j.anndiagpath.2013.01.005. PMID: 23707658

Clinical prediction guides

Prognostic gene profiles in the tumor microenvironment of ovarian serous adenocarcinoma.
Tian R, Zhao G, Zhou A, Li H, Cao B, Guo S
Front Biosci (Landmark Ed) 2021 Jan 1;26(4):692-705. doi: 10.2741/4913. PMID: 33049689
Deciphering serous ovarian carcinoma histopathology and platinum response by convolutional neural networks.
Yu KH, Hu V, Wang F, Matulonis UA, Mutter GL, Golden JA, Kohane IS
BMC Med 2020 Aug 18;18(1):236. doi: 10.1186/s12916-020-01684-w. PMID: 32807164Free PMC Article
The expression profile and prognostic value of APE/Ref-1 and NPM1 in high-grade serous ovarian adenocarcinoma.
Fan X, Wen L, Li Y, Lou L, Liu W, Zhang J
APMIS 2017 Oct;125(10):857-862. Epub 2017 Aug 2 doi: 10.1111/apm.12733. PMID: 28766835
Cryotherapy for liver metastases.
Bala MM, Riemsma RP, Wolff R, Kleijnen J
Cochrane Database Syst Rev 2013 Jun 5;(6):CD009058. doi: 10.1002/14651858.CD009058.pub2. PMID: 23740609
Axl and prostasin are biomarkers for prognosis of ovarian adenocarcinoma.
Chen PX, Li QY, Yang Z
Ann Diagn Pathol 2013 Oct;17(5):425-9. Epub 2013 May 23 doi: 10.1016/j.anndiagpath.2013.01.005. PMID: 23707658

Recent systematic reviews

Cryotherapy for liver metastases.
Bala MM, Riemsma RP, Wolff R, Kleijnen J
Cochrane Database Syst Rev 2013 Jun 5;(6):CD009058. doi: 10.1002/14651858.CD009058.pub2. PMID: 23740609

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