U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Thrombotic disease

MedGen UID:
21160
•Concept ID:
C0040053
•
Pathologic Function
Synonyms: Blood clot; Blood clots; Thrombosis; Thrombotic disorder
SNOMED CT: Thrombotic disorder (118927008); Thrombosis (439127006); Thrombosis (264579008)
 
Monarch Initiative: MONDO:0000831

Definition

The formation of a blood clot in the lumen of a vessel or heart chamber; causes include coagulation disorders and vascular endothelial injury. [from NCI]

Professional guidelines

PubMed

Management of anticoagulant-refractory thrombotic antiphospholipid syndrome.
Cohen H, Sayar Z, Efthymiou M, Gaspar P, Richards T, Isenberg D
Lancet Haematol 2020 Aug;7(8):e613-e623. doi: 10.1016/S2352-3026(20)30116-2. PMID: 32735839
Pathogenesis and Management of Thrombotic Disease in Myeloproliferative Neoplasms.
Arachchillage DR, Laffan M
Semin Thromb Hemost 2019 Sep;45(6):604-611. Epub 2019 Aug 5 doi: 10.1055/s-0039-1693477. PMID: 31382304
Clinical presentation & management of glomerular diseases: hematuria, nephritic & nephrotic syndrome.
Khanna R
Mo Med 2011 Jan-Feb;108(1):33-6. PMID: 21462608Free PMC Article

Recent clinical studies

Etiology

Genetic aspects of thrombotic disease.
García de Frutos P, Zöller B
Thromb Haemost 2015 Nov;114(5):883-4. Epub 2015 Oct 15 doi: 10.1160/TH15-10-0774. PMID: 26467566
Behcet's Syndrome.
Dalvi SR, Yildirim R, Yazici Y
Drugs 2012 Dec 3;72(17):2223-41. doi: 10.2165/11641370-000000000-00000. PMID: 23153327
Microparticles and thrombotic disease.
Davizon P, López JA
Curr Opin Hematol 2009 Sep;16(5):334-41. doi: 10.1097/MOH.0b013e32832ea49c. PMID: 19606028
Hyperhomocysteinaemia.
Perry DJ
Baillieres Best Pract Res Clin Haematol 1999 Sep;12(3):451-77. doi: 10.1053/beha.1999.0036. PMID: 10856981
Hyperhomocysteinemia and thrombosis.
Guba SC, Fonseca V, Fink LM
Semin Thromb Hemost 1999;25(3):291-309. doi: 10.1055/s-2007-994932. PMID: 10443960

Diagnosis

Antiphospholipid syndrome in obstetrics.
Kemp M, Thomas W
Lupus 2018 Oct;27(1_suppl):28-31. doi: 10.1177/0961203318801664. PMID: 30452326
Fibrin(ogen) and thrombotic disease.
Ariëns RA
J Thromb Haemost 2013 Jun;11 Suppl 1:294-305. doi: 10.1111/jth.12229. PMID: 23809133
Behcet's Syndrome.
Dalvi SR, Yildirim R, Yazici Y
Drugs 2012 Dec 3;72(17):2223-41. doi: 10.2165/11641370-000000000-00000. PMID: 23153327
Clinical presentation & management of glomerular diseases: hematuria, nephritic & nephrotic syndrome.
Khanna R
Mo Med 2011 Jan-Feb;108(1):33-6. PMID: 21462608Free PMC Article
Congenital thrombotic disorders.
Rodgers GM, Shuman MA
Am J Hematol 1986 Apr;21(4):419-30. doi: 10.1002/ajh.2830210411. PMID: 2937290

Therapy

SVEP1 is an endogenous ligand for the orphan receptor PEAR1.
Elenbaas JS, Pudupakkam U, Ashworth KJ, Kang CJ, Patel V, Santana K, Jung IH, Lee PC, Burks KH, Amrute JM, Mecham RP, Halabi CM, Alisio A, Di Paola J, Stitziel NO
Nat Commun 2023 Feb 15;14(1):850. doi: 10.1038/s41467-023-36486-0. PMID: 36792666Free PMC Article
Management of anticoagulant-refractory thrombotic antiphospholipid syndrome.
Cohen H, Sayar Z, Efthymiou M, Gaspar P, Richards T, Isenberg D
Lancet Haematol 2020 Aug;7(8):e613-e623. doi: 10.1016/S2352-3026(20)30116-2. PMID: 32735839
Behcet's Syndrome.
Dalvi SR, Yildirim R, Yazici Y
Drugs 2012 Dec 3;72(17):2223-41. doi: 10.2165/11641370-000000000-00000. PMID: 23153327
Ultrasound and thrombolysis.
Francis CW, Suchkova VN
Vasc Med 2001;6(3):181-7. doi: 10.1177/1358836x0100600309. PMID: 11789973
Hyperhomocysteinaemia.
Perry DJ
Baillieres Best Pract Res Clin Haematol 1999 Sep;12(3):451-77. doi: 10.1053/beha.1999.0036. PMID: 10856981

Prognosis

Management of incidental pulmonary embolism.
Klok FA, Huisman MV
Eur Respir J 2017 Jun;49(6) Epub 2017 Jun 29 doi: 10.1183/13993003.00275-2017. PMID: 28663318
Treatment of iliac-caval outflow obstruction.
Raju S
Semin Vasc Surg 2015 Mar;28(1):47-53. Epub 2015 Jul 17 doi: 10.1053/j.semvascsurg.2015.07.001. PMID: 26358309
Thrombotic disease in the myeloproliferative neoplasms.
Falanga A, Marchetti M
Hematology Am Soc Hematol Educ Program 2012;2012:571-81. doi: 10.1182/asheducation-2012.1.571. PMID: 23233637
Behcet's Syndrome.
Dalvi SR, Yildirim R, Yazici Y
Drugs 2012 Dec 3;72(17):2223-41. doi: 10.2165/11641370-000000000-00000. PMID: 23153327
Clinical presentation & management of glomerular diseases: hematuria, nephritic & nephrotic syndrome.
Khanna R
Mo Med 2011 Jan-Feb;108(1):33-6. PMID: 21462608Free PMC Article

Clinical prediction guides

Thrombotic triad in microgravity.
Elahi MM, Witt AN, Pryzdial ELG, McBeth PB
Thromb Res 2024 Jan;233:82-87. Epub 2023 Nov 22 doi: 10.1016/j.thromres.2023.11.020. PMID: 38029549
Management of anticoagulant-refractory thrombotic antiphospholipid syndrome.
Cohen H, Sayar Z, Efthymiou M, Gaspar P, Richards T, Isenberg D
Lancet Haematol 2020 Aug;7(8):e613-e623. doi: 10.1016/S2352-3026(20)30116-2. PMID: 32735839
Management of incidental pulmonary embolism.
Klok FA, Huisman MV
Eur Respir J 2017 Jun;49(6) Epub 2017 Jun 29 doi: 10.1183/13993003.00275-2017. PMID: 28663318
Molecular Imaging of Atherothrombotic Diseases: Seeing Is Believing.
Wang X, Peter K
Arterioscler Thromb Vasc Biol 2017 Jun;37(6):1029-1040. Epub 2017 Apr 27 doi: 10.1161/ATVBAHA.116.306483. PMID: 28450298
Thrombotic disease in the myeloproliferative neoplasms.
Falanga A, Marchetti M
Hematology Am Soc Hematol Educ Program 2012;2012:571-81. doi: 10.1182/asheducation-2012.1.571. PMID: 23233637

Recent systematic reviews

A Systematic Review of the Safety and Efficacy of Inferior Vena Cava Stenting.
Morris RI, Jackson N, Smith A, Black SA
Eur J Vasc Endovasc Surg 2023 Feb;65(2):298-308. Epub 2022 Nov 9 doi: 10.1016/j.ejvs.2022.11.006. PMID: 36334902
2021 Focused Update Consensus Guidelines of the Asia Pacific Heart Rhythm Society on Stroke Prevention in Atrial Fibrillation: Executive Summary.
Chao TF, Joung B, Takahashi Y, Lim TW, Choi EK, Chan YH, Guo Y, Sriratanasathavorn C, Oh S, Okumura K, Lip GYH
Thromb Haemost 2022 Jan;122(1):20-47. Epub 2021 Nov 13 doi: 10.1055/s-0041-1739411. PMID: 34773920Free PMC Article
Physical activity and risk of venous thromboembolism: systematic review and meta-analysis of prospective cohort studies.
Kunutsor SK, Mäkikallio TH, Seidu S, de Araújo CGS, Dey RS, Blom AW, Laukkanen JA
Eur J Epidemiol 2020 May;35(5):431-442. Epub 2019 Nov 14 doi: 10.1007/s10654-019-00579-2. PMID: 31728878Free PMC Article
Intravenous heparin during ruptured abdominal aortic aneurysmal repair.
Lammy S, Blackmur JP, Perkins JM
Cochrane Database Syst Rev 2016 Aug 19;2016(8):CD011486. doi: 10.1002/14651858.CD011486.pub2. PMID: 27541335Free PMC Article
Is chronic HIV infection associated with venous thrombotic disease? A systematic review.
Klein SK, Slim EJ, de Kruif MD, Keller TT, ten Cate H, van Gorp EC, Brandjes DP
Neth J Med 2005 Apr;63(4):129-36. PMID: 15869040

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...