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Barretts esophagus with high grade dysplasia

MedGen UID:
232283
•Concept ID:
C1334003
•
Disease or Syndrome
Synonyms: High Grade Dysplasia in Barrett Esophagus; High Grade Dysplasia in Barrett's Esophagus
SNOMED CT: Barretts esophagus with high grade dysplasia (1082761000119106)

Definition

A finding indicating the presence of Barrett esophagus in which there is marked nuclear pleomorphism and loss of polarity, increased number of atypical mitotic figures, and crypt budding, branching, and crowding. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBarretts esophagus with high grade dysplasia

Professional guidelines

PubMed

Diagnosis and management of Barrett esophagus: European Society of Gastrointestinal Endoscopy (ESGE) Guideline.
Weusten BLAM, Bisschops R, Dinis-Ribeiro M, di Pietro M, Pech O, Spaander MCW, Baldaque-Silva F, Barret M, Coron E, Fernández-Esparrach G, Fitzgerald RC, Jansen M, Jovani M, Marques-de-Sa I, Rattan A, Tan WK, Verheij EPD, Zellenrath PA, Triantafyllou K, Pouw RE
Endoscopy 2023 Dec;55(12):1124-1146. Epub 2023 Oct 9 doi: 10.1055/a-2176-2440. PMID: 37813356
Diagnosis and Management of Barrett's Esophagus: An Updated ACG Guideline.
Shaheen NJ, Falk GW, Iyer PG, Souza RF, Yadlapati RH, Sauer BG, Wani S
Am J Gastroenterol 2022 Apr 1;117(4):559-587. doi: 10.14309/ajg.0000000000001680. PMID: 35354777Free PMC Article
Esophageal cancer: Risk factors, screening and endoscopic treatment in Western and Eastern countries.
Domper Arnal MJ, Ferrández Arenas Á, Lanas Arbeloa Á
World J Gastroenterol 2015 Jul 14;21(26):7933-43. doi: 10.3748/wjg.v21.i26.7933. PMID: 26185366Free PMC Article

Recent clinical studies

Etiology

Low-grade dysplasia in Barrett's esophagus: A problematic diagnosis.
Sarem M, Martínez Cerezo FJ, Salvia Favieres ML, Corti R
Gastroenterol Hepatol 2023 Oct;46(8):637-644. Epub 2022 Oct 13 doi: 10.1016/j.gastrohep.2022.10.002. PMID: 36243250
AGA Clinical Practice Update on Endoscopic Treatment of Barrett's Esophagus With Dysplasia and/or Early Cancer: Expert Review.
Sharma P, Shaheen NJ, Katzka D, Bergman JJGHM
Gastroenterology 2020 Feb;158(3):760-769. Epub 2019 Nov 12 doi: 10.1053/j.gastro.2019.09.051. PMID: 31730766
ACG Clinical Guideline: Diagnosis and Management of Barrett's Esophagus.
Shaheen NJ, Falk GW, Iyer PG, Gerson LB; American College of Gastroenterology
Am J Gastroenterol 2016 Jan;111(1):30-50; quiz 51. Epub 2015 Nov 3 doi: 10.1038/ajg.2015.322. PMID: 26526079Free PMC Article
Biomarkers in Barrett's Esophagus: Role in Diagnosis, Risk Stratification, and Prediction of Response to Therapy.
Bansal A, Fitzgerald RC
Gastroenterol Clin North Am 2015 Jun;44(2):373-90. Epub 2015 Mar 18 doi: 10.1016/j.gtc.2015.02.008. PMID: 26021200
High-grade dysplasia in Barrett's esophagus. The case for esophagectomy.
Collard JM
Chest Surg Clin N Am 2002 Feb;12(1):77-92. doi: 10.1016/s1052-3359(03)00067-x. PMID: 11901935

Diagnosis

Management of Dysplastic Barrett's Esophagus and Early Esophageal Adenocarcinoma.
Cotton CC, Eluri S, Shaheen NJ
Gastroenterol Clin North Am 2022 Sep;51(3):485-500. Epub 2022 Aug 30 doi: 10.1016/j.gtc.2022.06.004. PMID: 36153106Free PMC Article
Diagnosis and Management of Barrett's Esophagus: An Updated ACG Guideline.
Shaheen NJ, Falk GW, Iyer PG, Souza RF, Yadlapati RH, Sauer BG, Wani S
Am J Gastroenterol 2022 Apr 1;117(4):559-587. doi: 10.14309/ajg.0000000000001680. PMID: 35354777Free PMC Article
AGA Clinical Practice Update on Endoscopic Treatment of Barrett's Esophagus With Dysplasia and/or Early Cancer: Expert Review.
Sharma P, Shaheen NJ, Katzka D, Bergman JJGHM
Gastroenterology 2020 Feb;158(3):760-769. Epub 2019 Nov 12 doi: 10.1053/j.gastro.2019.09.051. PMID: 31730766
ACG Clinical Guideline: Diagnosis and Management of Barrett's Esophagus.
Shaheen NJ, Falk GW, Iyer PG, Gerson LB; American College of Gastroenterology
Am J Gastroenterol 2016 Jan;111(1):30-50; quiz 51. Epub 2015 Nov 3 doi: 10.1038/ajg.2015.322. PMID: 26526079Free PMC Article
Management of high-grade dysplasia and intramucosal adenocarcinoma in Barrett's esophagus.
Wani S, Early D, Edmundowicz S, Sharma P
Clin Gastroenterol Hepatol 2012 Jul;10(7):704-11. Epub 2012 Apr 13 doi: 10.1016/j.cgh.2012.03.030. PMID: 22507878

Therapy

AGA Clinical Practice Guideline on Endoscopic Eradication Therapy of Barrett's Esophagus and Related Neoplasia.
Rubenstein JH, Sawas T, Wani S, Eluri S, Singh S, Chandar AK, Perumpail RB, Inadomi JM, Thrift AP, Piscoya A, Sultan S, Singh S, Katzka D, Davitkov P
Gastroenterology 2024 Jun;166(6):1020-1055. doi: 10.1053/j.gastro.2024.03.019. PMID: 38763697Free PMC Article
Diagnosis and management of Barrett esophagus: European Society of Gastrointestinal Endoscopy (ESGE) Guideline.
Weusten BLAM, Bisschops R, Dinis-Ribeiro M, di Pietro M, Pech O, Spaander MCW, Baldaque-Silva F, Barret M, Coron E, Fernández-Esparrach G, Fitzgerald RC, Jansen M, Jovani M, Marques-de-Sa I, Rattan A, Tan WK, Verheij EPD, Zellenrath PA, Triantafyllou K, Pouw RE
Endoscopy 2023 Dec;55(12):1124-1146. Epub 2023 Oct 9 doi: 10.1055/a-2176-2440. PMID: 37813356
Management of Dysplastic Barrett's Esophagus and Early Esophageal Adenocarcinoma.
Cotton CC, Eluri S, Shaheen NJ
Gastroenterol Clin North Am 2022 Sep;51(3):485-500. Epub 2022 Aug 30 doi: 10.1016/j.gtc.2022.06.004. PMID: 36153106Free PMC Article
AGA Clinical Practice Update on New Technology and Innovation for Surveillance and Screening in Barrett's Esophagus: Expert Review.
Muthusamy VR, Wani S, Gyawali CP, Komanduri S; CGIT Barrett’s Esophagus Consensus Conference Participants
Clin Gastroenterol Hepatol 2022 Dec;20(12):2696-2706.e1. Epub 2022 Jul 3 doi: 10.1016/j.cgh.2022.06.003. PMID: 35788412Free PMC Article
AGA Clinical Practice Update on Endoscopic Treatment of Barrett's Esophagus With Dysplasia and/or Early Cancer: Expert Review.
Sharma P, Shaheen NJ, Katzka D, Bergman JJGHM
Gastroenterology 2020 Feb;158(3):760-769. Epub 2019 Nov 12 doi: 10.1053/j.gastro.2019.09.051. PMID: 31730766

Prognosis

Biomarkers in Barrett's Esophagus: Role in Diagnosis, Risk Stratification, and Prediction of Response to Therapy.
Bansal A, Fitzgerald RC
Gastroenterol Clin North Am 2015 Jun;44(2):373-90. Epub 2015 Mar 18 doi: 10.1016/j.gtc.2015.02.008. PMID: 26021200
Endotherapy for Barrett's esophagus with high-grade dysplasia and intramucosal carcinoma.
Schembre DB
J Gastrointest Surg 2009 Jul;13(7):1172-8. Epub 2009 Mar 26 doi: 10.1007/s11605-009-0862-2. PMID: 19322616
New options for the therapy of Barrett's high-grade dysplasia and intramucosal adenocarcinoma: endoscopic mucosal resection and ablation versus vagal-sparing esophagectomy.
DeMeester SR
Ann Thorac Surg 2008 Feb;85(2):S747-50. doi: 10.1016/j.athoracsur.2007.10.102. PMID: 18222209
Pro: esophagectomy is the treatment of choice for high-grade dysplasia in Barrett's esophagus.
Rice TW
Am J Gastroenterol 2006 Oct;101(10):2177-9. doi: 10.1111/j.1572-0241.2006.00864_1.x. PMID: 17032178
High-grade dysplasia in Barrett's esophagus. The case for esophagectomy.
Collard JM
Chest Surg Clin N Am 2002 Feb;12(1):77-92. doi: 10.1016/s1052-3359(03)00067-x. PMID: 11901935

Clinical prediction guides

AGA Clinical Practice Update on New Technology and Innovation for Surveillance and Screening in Barrett's Esophagus: Expert Review.
Muthusamy VR, Wani S, Gyawali CP, Komanduri S; CGIT Barrett’s Esophagus Consensus Conference Participants
Clin Gastroenterol Hepatol 2022 Dec;20(12):2696-2706.e1. Epub 2022 Jul 3 doi: 10.1016/j.cgh.2022.06.003. PMID: 35788412Free PMC Article
Management of Barrett's esophagus with low-grade dysplasia.
Harrison M, Allen JE, Gorrepati VS, López-Jamar JME, Sharma P
Dis Esophagus 2018 Apr 1;31(4) doi: 10.1093/dote/doy004. PMID: 29506235
Esophageal cancer: Risk factors, screening and endoscopic treatment in Western and Eastern countries.
Domper Arnal MJ, Ferrández Arenas Á, Lanas Arbeloa Á
World J Gastroenterol 2015 Jul 14;21(26):7933-43. doi: 10.3748/wjg.v21.i26.7933. PMID: 26185366Free PMC Article
Biomarkers in Barrett's Esophagus: Role in Diagnosis, Risk Stratification, and Prediction of Response to Therapy.
Bansal A, Fitzgerald RC
Gastroenterol Clin North Am 2015 Jun;44(2):373-90. Epub 2015 Mar 18 doi: 10.1016/j.gtc.2015.02.008. PMID: 26021200
High-grade dysplasia in Barrett's esophagus. The case for esophagectomy.
Collard JM
Chest Surg Clin N Am 2002 Feb;12(1):77-92. doi: 10.1016/s1052-3359(03)00067-x. PMID: 11901935

Recent systematic reviews

Gender differences in Barrett's esophagus and progression of disease: a systematic review and meta-analysis.
Stephanie M, Nour H, de Sá Inês M, Shanker K, Kevin K, Mario DR, Prateek S
Dis Esophagus 2022 May 10;35(5) doi: 10.1093/dote/doab075. PMID: 34761256
Magnitude and Time-Trend Analysis of Postendoscopy Esophageal Adenocarcinoma: A Systematic Review and Meta-analysis.
Sawas T, Majzoub AM, Haddad J, Tielleman T, Nayfeh T, Yadlapati R, Singh S, Kolb J, Vajravelu RK, Katzka DA, Wani S; Post-Endoscopy Esophageal Adenocarcinoma Consensus Panel
Clin Gastroenterol Hepatol 2022 Feb;20(2):e31-e50. Epub 2021 Apr 23 doi: 10.1016/j.cgh.2021.04.032. PMID: 33901662Free PMC Article
Systematic review with meta-analysis: neoplasia detection rate and post-endoscopy Barrett's neoplasia in Barrett's oesophagus.
Hamade N, Kamboj AK, Krishnamoorthi R, Singh S, Hassett LC, Katzka DA, Kahi CJ, Fatima H, Iyer PG
Aliment Pharmacol Ther 2021 Sep;54(5):546-559. Epub 2021 Jul 18 doi: 10.1111/apt.16531. PMID: 34275161Free PMC Article
DIAGNOSIS, TREATMENT AND FOLLOW-UP OF BARRETT'S ESOPHAGUS: A SYSTEMATIC REVIEW.
Alves JR, Graffunder FP, Rech JVT, Ternes CMP, Koerich-Silva I
Arq Gastroenterol 2020 Jul-Sep;57(3):289-295. doi: 10.1590/S0004-2803.202000000-53. PMID: 33027480
Factors Associated With Progression of Barrett's Esophagus: A Systematic Review and Meta-analysis.
Krishnamoorthi R, Singh S, Ragunathan K, Visrodia K, Wang KK, Katzka DA, Iyer PG
Clin Gastroenterol Hepatol 2018 Jul;16(7):1046-1055.e8. Epub 2017 Dec 2 doi: 10.1016/j.cgh.2017.11.044. PMID: 29199147

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