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Vaginal squamous tumor

MedGen UID:
274381
•Concept ID:
C1519931
•
Neoplastic Process
Synonyms: vagina squamous cell neoplasm; Vaginal Squamous Neoplasm; vaginal squamous neoplasm; Vaginal Squamous Tumor; vaginal squamous tumor
 
Monarch Initiative: MONDO:0001806

Definition

A benign, precancerous, or malignant neoplasm that arises from the squamous epithelium of the vagina. [from NCI]

Professional guidelines

PubMed

The European Society of Gynaecological Oncology (ESGO), the International Society for the Study of Vulvovaginal Disease (ISSVD), the European College for the Study of Vulval Disease (ECSVD), and the European Federation for Colposcopy (EFC) consensus statement on the management of vaginal intraepithelial neoplasia.
Kesic V, Carcopino X, Preti M, Vieira-Baptista P, Bevilacqua F, Bornstein J, Chargari C, Cruickshank M, Erzeneoglu E, Gallio N, Gultekin M, Heller D, Joura E, Kyrgiou M, Madić T, Planchamp F, Regauer S, Reich O, Esat Temiz B, Woelber L, Zodzika J, Stockdale C
Int J Gynecol Cancer 2023 Apr 3;33(4):446-461. doi: 10.1136/ijgc-2022-004213. PMID: 36958755Free PMC Article
ECOG-ACRIN Guideline for Contouring and Treatment of Early Stage Anal Cancer Using IMRT/IGRT.
Damico N, Meyer J, Das P, Murphy J, Miller E, Koontz B, Hall W, McBride M, Pereira G, Catalano P, Chakravarthy AB, O'Dwyer PJ, Dorth J
Pract Radiat Oncol 2022 Jul-Aug;12(4):335-347. doi: 10.1016/j.prro.2022.01.015. PMID: 35717050
Cervical Colposcopy: Indications and Risk Assessment.
Burness JV, Schroeder JM, Warren JB
Am Fam Physician 2020 Jul 1;102(1):39-48. PMID: 32603071

Recent clinical studies

Etiology

Cancer of the vagina: 2021 update.
Adams TS, Rogers LJ, Cuello MA
Int J Gynaecol Obstet 2021 Oct;155 Suppl 1(Suppl 1):19-27. doi: 10.1002/ijgo.13867. PMID: 34669198Free PMC Article
Multizonal anogenital neoplasia in women: a cohort analysis.
Albuquerque A, Godfrey MAL, Cappello C, Pesola F, Bowring J, Cuming T, De Masi A, Rosenthal AN, Sasieni P, Nathan M
BMC Cancer 2021 Mar 6;21(1):232. doi: 10.1186/s12885-021-07949-8. PMID: 33676451Free PMC Article
Human papillomavirus infection and cervical intraepithelial neoplasia progression are associated with increased vaginal microbiome diversity in a Chinese cohort.
Chen Y, Qiu X, Wang W, Li D, Wu A, Hong Z, Di W, Qiu L
BMC Infect Dis 2020 Aug 26;20(1):629. doi: 10.1186/s12879-020-05324-9. PMID: 32842982Free PMC Article
Microinvasive squamous carcinoma of neovagina created with peritoneal flap (Davidov): Case report and literature review.
Reyes Claret A, Martín Jiménez Á, Robles Gourley AA, Ibarra de la Rosa JM, Vicens Vidal M
J Obstet Gynaecol 2017 Jan;37(1):131-135. Epub 2016 Nov 21 doi: 10.1080/01443615.2016.1234445. PMID: 27866418
Cervical cancer.
Shepherd JH
Best Pract Res Clin Obstet Gynaecol 2012 Jun;26(3):293-309. Epub 2012 Feb 19 doi: 10.1016/j.bpobgyn.2011.12.004. PMID: 22353492

Diagnosis

Squamous and Glandular Lesions of the Vulva and Vagina: What's New and What Remains Unanswered?
Wei KX, Hoang LN
Surg Pathol Clin 2022 Jun;15(2):389-405. Epub 2022 May 20 doi: 10.1016/j.path.2022.02.011. PMID: 35715167
Cancer of the vagina: 2021 update.
Adams TS, Rogers LJ, Cuello MA
Int J Gynaecol Obstet 2021 Oct;155 Suppl 1(Suppl 1):19-27. doi: 10.1002/ijgo.13867. PMID: 34669198Free PMC Article
Erosive diseases of the vulva.
Pipkin C
Dermatol Clin 2010 Oct;28(4):737-51. Epub 2010 Sep 15 doi: 10.1016/j.det.2010.08.005. PMID: 20883917
Primary vaginal cancer.
Goodman A
Surg Oncol Clin N Am 1998 Apr;7(2):347-61. PMID: 9537981
Definition of precursors in gynecologic cancer.
Scully RE
Cancer 1981 Jul 15;48(2 Suppl):531-7. doi: 10.1002/1097-0142(19810715)48:1+<531::aid-cncr2820481316>3.0.co;2-c. PMID: 7023663

Therapy

The European Society of Gynaecological Oncology (ESGO), the International Society for the Study of Vulvovaginal Disease (ISSVD), the European College for the Study of Vulval Disease (ECSVD), and the European Federation for Colposcopy (EFC) consensus statement on the management of vaginal intraepithelial neoplasia.
Kesic V, Carcopino X, Preti M, Vieira-Baptista P, Bevilacqua F, Bornstein J, Chargari C, Cruickshank M, Erzeneoglu E, Gallio N, Gultekin M, Heller D, Joura E, Kyrgiou M, Madić T, Planchamp F, Regauer S, Reich O, Esat Temiz B, Woelber L, Zodzika J, Stockdale C
Int J Gynecol Cancer 2023 Apr 3;33(4):446-461. doi: 10.1136/ijgc-2022-004213. PMID: 36958755Free PMC Article
ECOG-ACRIN Guideline for Contouring and Treatment of Early Stage Anal Cancer Using IMRT/IGRT.
Damico N, Meyer J, Das P, Murphy J, Miller E, Koontz B, Hall W, McBride M, Pereira G, Catalano P, Chakravarthy AB, O'Dwyer PJ, Dorth J
Pract Radiat Oncol 2022 Jul-Aug;12(4):335-347. doi: 10.1016/j.prro.2022.01.015. PMID: 35717050
Hormone Replacement Therapy in Cancer Survivors - Review of the Literature.
Deli T, Orosz M, Jakab A
Pathol Oncol Res 2020 Jan;26(1):63-78. Epub 2019 Jan 8 doi: 10.1007/s12253-018-00569-x. PMID: 30617760Free PMC Article
Prevention of cervix cancer.
Rock CL, Michael CW, Reynolds RK, Ruffin MT
Crit Rev Oncol Hematol 2000 Mar;33(3):169-85. doi: 10.1016/s1040-8428(99)00073-6. PMID: 10789491
Cancer of the uterine cervix.
Cannistra SA, Niloff JM
N Engl J Med 1996 Apr 18;334(16):1030-8. doi: 10.1056/NEJM199604183341606. PMID: 8598842

Prognosis

Multizonal anogenital neoplasia in women: a cohort analysis.
Albuquerque A, Godfrey MAL, Cappello C, Pesola F, Bowring J, Cuming T, De Masi A, Rosenthal AN, Sasieni P, Nathan M
BMC Cancer 2021 Mar 6;21(1):232. doi: 10.1186/s12885-021-07949-8. PMID: 33676451Free PMC Article
Staging for vaginal cancer.
Rajaram S, Maheshwari A, Srivastava A
Best Pract Res Clin Obstet Gynaecol 2015 Aug;29(6):822-32. Epub 2015 Mar 4 doi: 10.1016/j.bpobgyn.2015.01.006. PMID: 25847318
Empty pelvis syndrome.
Ghosh PS, Fawzi H
J Obstet Gynaecol 2004 Sep;24(6):714-5. doi: 10.1080/01443610400008248. PMID: 16147629
Natural history of vaginal intraepithelial neoplasia.
Aho M, Vesterinen E, Meyer B, Purola E, Paavonen J
Cancer 1991 Jul 1;68(1):195-7. doi: 10.1002/1097-0142(19910701)68:1<195::aid-cncr2820680135>3.0.co;2-l. PMID: 2049744
Cervical and vaginal cytology in the child and adolescent.
Kaufman RH, Leeds LJ
Pediatr Clin North Am 1972 Aug;19(3):547-57. doi: 10.1016/s0031-3955(16)32738-9. PMID: 5039349

Clinical prediction guides

Primary and secondary malignant involvement of gynaecological organs at radical cystectomy for bladder cancer: review of literature and retrospective analysis of 360 cases.
Salem H, El-Mazny A
J Obstet Gynaecol 2012 Aug;32(6):590-3. doi: 10.3109/01443615.2012.693980. PMID: 22779969
Observer variation, dysplasia grading, and HPV typing: a review.
Llewellyn H
Am J Clin Pathol 2000 Nov;114 Suppl:S21-35. doi: 10.1093/ppr/114.1.s21. PMID: 11996166
Primary squamous cell carcinoma of the neovagina.
Baltzer J, Zander J
Gynecol Oncol 1989 Oct;35(1):99-103. doi: 10.1016/0090-8258(89)90021-8. PMID: 2676753
Pathology of colposcopic findings in 2635 diethylstilbestrol-exposed young women.
Welch WR, Robboy SJ, Kaufman RH, Townsend D, Noller KL, Gundersen J, Lawrence WD, Richart RM, O'Brien P, McGorray S
Gynecol Oncol 1985 Jul;21(3):277-86. doi: 10.1016/0090-8258(85)90264-1. PMID: 4007608
Radiation changes in vaginal and cervical cytology in carcinoma of the cervix uteri.
Gupta S, Gupta YN, Sanyal B
J Surg Oncol 1982 Feb;19(2):71-3. doi: 10.1002/jso.2930190204. PMID: 7057651

Recent systematic reviews

The prognostic significance of HPV, p16, and p53 protein expression in vaginal cancer: A systematic review.
Rasmussen CL, Bertoli HK, Sand FL, Kjaer AK, Thomsen LT, Kjaer SK
Acta Obstet Gynecol Scand 2021 Dec;100(12):2144-2156. Epub 2021 Sep 21 doi: 10.1111/aogs.14260. PMID: 34546565
Human papillomavirus and p16 in squamous cell carcinoma and intraepithelial neoplasia of the vagina.
Bertoli HK, Rasmussen CL, Sand FL, Albieri V, Norrild B, Verdoodt F, Kjaer SK
Int J Cancer 2019 Jul 1;145(1):78-86. Epub 2019 Jan 11 doi: 10.1002/ijc.32078. PMID: 30561092
Definitive Radiotherapy in Invasive Vaginal Carcinoma: A Systematic Review.
Guerri S, Perrone AM, Buwenge M, Ferioli M, Macchia G, Tagliaferri L, Ferrandina G, Galuppi A, Andrulli AD, Frakulli R, Cammelli S, Arcelli A, De Iaco P, Morganti AG
Oncologist 2019 Jan;24(1):132-141. Epub 2018 Aug 23 doi: 10.1634/theoncologist.2017-0546. PMID: 30139838Free PMC Article
Cytology versus HPV testing for cervical cancer screening in the general population.
Koliopoulos G, Nyaga VN, Santesso N, Bryant A, Martin-Hirsch PP, Mustafa RA, Schünemann H, Paraskevaidis E, Arbyn M
Cochrane Database Syst Rev 2017 Aug 10;8(8):CD008587. doi: 10.1002/14651858.CD008587.pub2. PMID: 28796882Free PMC Article
Association between bacterial vaginosis and cervical intraepithelial neoplasia: systematic review and meta-analysis.
Gillet E, Meys JF, Verstraelen H, Verhelst R, De Sutter P, Temmerman M, Vanden Broeck D
PLoS One 2012;7(10):e45201. Epub 2012 Oct 2 doi: 10.1371/journal.pone.0045201. PMID: 23056195Free PMC Article

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