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Squamous cell neoplasm

MedGen UID:
60219
•Concept ID:
C0206720
•
Neoplastic Process
Synonyms: Cell Neoplasm, Squamous; Cell Neoplasms, Squamous; Neoplasm, Squamous Cell; Neoplasms, Squamous Cell; Squamous Cell Neoplasm; Squamous Cell Neoplasms
SNOMED CT: Squamous cell neoplasm (118286007)
 
Monarch Initiative: MONDO:0002532

Definition

A neoplasm that is composed of squamous epithelial cells. Squamous cell carcinoma is a representative example. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSquamous cell neoplasm

Professional guidelines

PubMed

HPV-associated oropharyngeal cancer: epidemiology, molecular biology and clinical management.
Lechner M, Liu J, Masterson L, Fenton TR
Nat Rev Clin Oncol 2022 May;19(5):306-327. Epub 2022 Feb 1 doi: 10.1038/s41571-022-00603-7. PMID: 35105976Free PMC Article
Albinism: epidemiology, genetics, cutaneous characterization, psychosocial factors.
Marçon CR, Maia M
An Bras Dermatol 2019 Sep-Oct;94(5):503-520. Epub 2019 Sep 30 doi: 10.1016/j.abd.2019.09.023. PMID: 31777350Free PMC Article
Delineation of the primary tumour Clinical Target Volumes (CTV-P) in laryngeal, hypopharyngeal, oropharyngeal and oral cavity squamous cell carcinoma: AIRO, CACA, DAHANCA, EORTC, GEORCC, GORTEC, HKNPCSG, HNCIG, IAG-KHT, LPRHHT, NCIC CTG, NCRI, NRG Oncology, PHNS, SBRT, SOMERA, SRO, SSHNO, TROG consensus guidelines.
Grégoire V, Evans M, Le QT, Bourhis J, Budach V, Chen A, Eisbruch A, Feng M, Giralt J, Gupta T, Hamoir M, Helito JK, Hu C, Hunter K, Johansen J, Kaanders J, Laskar SG, Lee A, Maingon P, Mäkitie A, Micciche' F, Nicolai P, O'Sullivan B, Poitevin A, Porceddu S, Składowski K, Tribius S, Waldron J, Wee J, Yao M, Yom SS, Zimmermann F, Grau C
Radiother Oncol 2018 Jan;126(1):3-24. Epub 2017 Nov 24 doi: 10.1016/j.radonc.2017.10.016. PMID: 29180076

Recent clinical studies

Etiology

Prevention and management of esophageal stricture after esophageal ESD: 10 years of experience in a single medical center.
Hsu WH, Shih HY, Shen CS, Yu FJ, Wang HC, Chan LP, Kuo CH, Hsieh HM, Wu IC
J Formos Med Assoc 2023 Jun;122(6):486-492. Epub 2022 Dec 24 doi: 10.1016/j.jfma.2022.12.006. PMID: 36572585
Vitamin D receptor gene polymorphisms in ocular surface squamous cell neoplasms.
Ismayilova N, Palamar M, Onay H, Ceylan EI, Atik T, Akalin T, Yagci A
Eur J Ophthalmol 2020 Sep;30(5):901-907. Epub 2019 Jun 24 doi: 10.1177/1120672119858225. PMID: 31232112
Cancer in the HIV/AIDS Population in Iowa, 1991-2015.
Jacoby E, Kahl AR, Jatta A, Kolm-Valdivia N, Brubaker J, Charlton ME, Lynch CF
J Registry Manag 2019 Spring;46(1):4-14. PMID: 31490916Free PMC Article
Routine endoscopic screening for synchronous esophageal neoplasm in patients with head and neck squamous cell carcinoma: a prospective study.
Gong EJ, Kim DH, Ahn JY, Choi KS, Jung KW, Lee JH, Choi KD, Song HJ, Lee GH, Jung HY, Kim JH, Roh JL, Choi SH, Nam SY, Kim SY
Dis Esophagus 2016 Oct;29(7):752-759. Epub 2015 Oct 15 doi: 10.1111/dote.12404. PMID: 26471351
Clinical significance of intensive endoscopic screening for synchronous esophageal neoplasm in patients with head and neck squamous cell carcinoma.
Kim DH, Gong EJ, Jung HY, Lim H, Ahn JY, Choi KS, Lee JH, Choi KD, Song HJ, Lee GH, Kim JH, Roh JL, Choi SH, Nam SY, Kim SY, Baek S
Scand J Gastroenterol 2014 Dec;49(12):1486-92. Epub 2014 Nov 5 doi: 10.3109/00365521.2013.832369. PMID: 25372595

Diagnosis

Vitamin D receptor gene polymorphisms in ocular surface squamous cell neoplasms.
Ismayilova N, Palamar M, Onay H, Ceylan EI, Atik T, Akalin T, Yagci A
Eur J Ophthalmol 2020 Sep;30(5):901-907. Epub 2019 Jun 24 doi: 10.1177/1120672119858225. PMID: 31232112
Cancer in the HIV/AIDS Population in Iowa, 1991-2015.
Jacoby E, Kahl AR, Jatta A, Kolm-Valdivia N, Brubaker J, Charlton ME, Lynch CF
J Registry Manag 2019 Spring;46(1):4-14. PMID: 31490916Free PMC Article
Endoscopic submucosal tunnel dissection and endoscopic submucosal dissection for large superficial esophageal squamous cell neoplasm: efficacy and safety study to guide future practice.
Zhang W, Zhai Y, Chai N, Linghu E, Lu Z, Li H, Feng X
Surg Endosc 2018 Jun;32(6):2814-2821. Epub 2017 Dec 20 doi: 10.1007/s00464-017-5986-y. PMID: 29264756
Routine endoscopic screening for synchronous esophageal neoplasm in patients with head and neck squamous cell carcinoma: a prospective study.
Gong EJ, Kim DH, Ahn JY, Choi KS, Jung KW, Lee JH, Choi KD, Song HJ, Lee GH, Jung HY, Kim JH, Roh JL, Choi SH, Nam SY, Kim SY
Dis Esophagus 2016 Oct;29(7):752-759. Epub 2015 Oct 15 doi: 10.1111/dote.12404. PMID: 26471351
Squamous Cell Neoplasm of the Ocular Surface in a Patient With Psoriasis Treated With Tumor Necrosis Factor-Alpha Inhibitors.
Lezcano Carduz VP, Mingo Botín D, Durán Poveda SP
Cornea 2015 Jul;34(7):833-4. doi: 10.1097/ICO.0000000000000465. PMID: 26010941

Therapy

Prevention and management of esophageal stricture after esophageal ESD: 10 years of experience in a single medical center.
Hsu WH, Shih HY, Shen CS, Yu FJ, Wang HC, Chan LP, Kuo CH, Hsieh HM, Wu IC
J Formos Med Assoc 2023 Jun;122(6):486-492. Epub 2022 Dec 24 doi: 10.1016/j.jfma.2022.12.006. PMID: 36572585
Vitamin D receptor gene polymorphisms in ocular surface squamous cell neoplasms.
Ismayilova N, Palamar M, Onay H, Ceylan EI, Atik T, Akalin T, Yagci A
Eur J Ophthalmol 2020 Sep;30(5):901-907. Epub 2019 Jun 24 doi: 10.1177/1120672119858225. PMID: 31232112
Stricture rate after chemoradiotherapy and radiotherapy for oesophageal squamous cell carcinoma: a 20-year experience.
Hamer PW, Hight SC, Ward IG, Harris DL, Woodham BL, Flint RS
ANZ J Surg 2019 Apr;89(4):367-371. Epub 2019 Feb 21 doi: 10.1111/ans.14981. PMID: 30791194
Squamous Cell Neoplasm of the Ocular Surface in a Patient With Psoriasis Treated With Tumor Necrosis Factor-Alpha Inhibitors.
Lezcano Carduz VP, Mingo Botín D, Durán Poveda SP
Cornea 2015 Jul;34(7):833-4. doi: 10.1097/ICO.0000000000000465. PMID: 26010941
Clinical significance of intensive endoscopic screening for synchronous esophageal neoplasm in patients with head and neck squamous cell carcinoma.
Kim DH, Gong EJ, Jung HY, Lim H, Ahn JY, Choi KS, Lee JH, Choi KD, Song HJ, Lee GH, Kim JH, Roh JL, Choi SH, Nam SY, Kim SY, Baek S
Scand J Gastroenterol 2014 Dec;49(12):1486-92. Epub 2014 Nov 5 doi: 10.3109/00365521.2013.832369. PMID: 25372595

Prognosis

Vitamin D receptor gene polymorphisms in ocular surface squamous cell neoplasms.
Ismayilova N, Palamar M, Onay H, Ceylan EI, Atik T, Akalin T, Yagci A
Eur J Ophthalmol 2020 Sep;30(5):901-907. Epub 2019 Jun 24 doi: 10.1177/1120672119858225. PMID: 31232112
Cancer in the HIV/AIDS Population in Iowa, 1991-2015.
Jacoby E, Kahl AR, Jatta A, Kolm-Valdivia N, Brubaker J, Charlton ME, Lynch CF
J Registry Manag 2019 Spring;46(1):4-14. PMID: 31490916Free PMC Article
Stricture rate after chemoradiotherapy and radiotherapy for oesophageal squamous cell carcinoma: a 20-year experience.
Hamer PW, Hight SC, Ward IG, Harris DL, Woodham BL, Flint RS
ANZ J Surg 2019 Apr;89(4):367-371. Epub 2019 Feb 21 doi: 10.1111/ans.14981. PMID: 30791194
Routine endoscopic screening for synchronous esophageal neoplasm in patients with head and neck squamous cell carcinoma: a prospective study.
Gong EJ, Kim DH, Ahn JY, Choi KS, Jung KW, Lee JH, Choi KD, Song HJ, Lee GH, Jung HY, Kim JH, Roh JL, Choi SH, Nam SY, Kim SY
Dis Esophagus 2016 Oct;29(7):752-759. Epub 2015 Oct 15 doi: 10.1111/dote.12404. PMID: 26471351
Clinical significance of intensive endoscopic screening for synchronous esophageal neoplasm in patients with head and neck squamous cell carcinoma.
Kim DH, Gong EJ, Jung HY, Lim H, Ahn JY, Choi KS, Lee JH, Choi KD, Song HJ, Lee GH, Kim JH, Roh JL, Choi SH, Nam SY, Kim SY, Baek S
Scand J Gastroenterol 2014 Dec;49(12):1486-92. Epub 2014 Nov 5 doi: 10.3109/00365521.2013.832369. PMID: 25372595

Clinical prediction guides

Detection of superficial esophageal squamous cell neoplasia by chromoendoscopy-guided confocal laser endomicroscopy.
Huang J, Yang YS, Lu ZS, Wang SF, Yang J, Yuan J
World J Gastroenterol 2015 Jun 14;21(22):6974-81. doi: 10.3748/wjg.v21.i22.6974. PMID: 26078575Free PMC Article
Keratoacanthoma occurring within the red dye of a tattoo.
Kluger N, Minier-Thoumin C, Plantier F
J Cutan Pathol 2008 May;35(5):504-7. Epub 2007 Nov 1 doi: 10.1111/j.1600-0560.2007.00833.x. PMID: 17976209
The 1998 Pan American Lecture. Intraocular invasion of conjunctival squamous cell carcinoma in five patients.
Shields JA, Shields CL, Gunduz K, Eagle RC Jr
Ophthalmic Plast Reconstr Surg 1999 May;15(3):153-60. doi: 10.1097/00002341-199905000-00003. PMID: 10355832
Occupational respiratory cancer and exposure to asbestos: a case-control study in a cohort of workers in the electricity and gas industry.
Imbernon E, Goldberg M, Bonenfant S, Chevalier A, Guénel P, Vatré R, Dehaye J
Am J Ind Med 1995 Sep;28(3):339-52. doi: 10.1002/ajim.4700280304. PMID: 7485188

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