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Ovarian Dermoid Cyst with Secondary Carcinoma

MedGen UID:
275286
•Concept ID:
C1518705
•
Neoplastic Process

Definition

A secondary carcinoma that has developed in an ovarian dermoid cyst. In the majority of cases, the secondary carcinoma is a squamous cell carcinoma. [from NCI]

Professional guidelines

PubMed

Ovarian cancer: diagnosis and treatment.
Girtanner R
Compr Ther 1980 May;6(5):30-8. PMID: 7379486

Recent clinical studies

Etiology

A series of malignant ovarian cancers arising from within a mature cystic teratoma: a single institution experience.
Black JD, Roque DM, Pasternak MC, Buza N, Rutherford TJ, Schwartz PE, McCarthy S, Ratner E
Int J Gynecol Cancer 2015 Jun;25(5):792-7. doi: 10.1097/IGC.0000000000000431. PMID: 25790042
Secondary malignancies in ovarian dermoid cyst.
Al-Rayyan ES, Duqoum WJ, Sawalha MS, Nascimento MC, Pather S, Dalrymple CJ, Carter JR
Saudi Med J 2009 Apr;30(4):524-8. PMID: 19370280
Secondary malignant involvement of gynecologic organs in radical cystectomy specimens in women: is it mandatory to remove these organs routinely?
Ali-El-Dein B, Abdel-Latif M, Mosbah A, Eraky I, Shaaban AA, Taha NM, Ghoneim MA
J Urol 2004 Sep;172(3):885-7. doi: 10.1097/01.ju.0000133986.29257.bf. PMID: 15310990
Carcinoids of the ovary: an analysis of 329 reported cases.
Soga J, Osaka M, Yakuwa Y
J Exp Clin Cancer Res 2000 Sep;19(3):271-80. PMID: 11144518
Malignancy associated with benign cystic teratomas (dermoid cysts) of the ovary.
Singh P, Yordan EL, Wilbanks GD, Miller AW, Wee A
Singapore Med J 1988 Feb;29(1):30-4. PMID: 2841767

Diagnosis

Malignant transformation of mature cystic teratoma of the ovary.
Atwi D, Kamal M, Quinton M, Hassell LA
J Obstet Gynaecol Res 2022 Dec;48(12):3068-3076. Epub 2022 Sep 2 doi: 10.1111/jog.15409. PMID: 36053141
Squamous cell carcinoma and osteosarcoma arising from a dermoid cyst--a case report and review of literature.
Allam-Nandyala P, Bui MM, Caracciolo JT, Hakam A
Int J Clin Exp Pathol 2010 Jan 10;3(3):313-8. PMID: 20224730Free PMC Article
Ruptured benign cystic teratomas mimicking gynecologic malignancy.
Stuart GC, Smith JP
Gynecol Oncol 1983 Aug;16(1):139-43. doi: 10.1016/0090-8258(83)90019-7. PMID: 6884826
Ovarian cancer: diagnosis and treatment.
Girtanner R
Compr Ther 1980 May;6(5):30-8. PMID: 7379486
Ovarian tumors in children and adolescents.
Breen JL, Maxson WS
Clin Obstet Gynecol 1977 Sep;20(3):607-23. doi: 10.1097/00003081-197709000-00010. PMID: 196802

Therapy

A series of malignant ovarian cancers arising from within a mature cystic teratoma: a single institution experience.
Black JD, Roque DM, Pasternak MC, Buza N, Rutherford TJ, Schwartz PE, McCarthy S, Ratner E
Int J Gynecol Cancer 2015 Jun;25(5):792-7. doi: 10.1097/IGC.0000000000000431. PMID: 25790042
Peritoneal implantation of squamous cell carcinoma following rupture of a dermoid cyst during laparoscopic removal.
Mayer C, Miller DM, Ehlen TG
Gynecol Oncol 2002 Jan;84(1):180-3. doi: 10.1006/gyno.2001.6484. PMID: 11748999
Ovarian cancer: diagnosis and treatment.
Girtanner R
Compr Ther 1980 May;6(5):30-8. PMID: 7379486
Embryonal cell carcinoma (endodermal sinus type) of the ovary.
Blythe JG, Buchsbaum HJ
Hum Pathol 1973 Dec;4(4):595-9. doi: 10.1016/s0046-8177(73)80068-1. PMID: 4750824

Prognosis

Malignant transformation of mature cystic teratoma of the ovary.
Atwi D, Kamal M, Quinton M, Hassell LA
J Obstet Gynaecol Res 2022 Dec;48(12):3068-3076. Epub 2022 Sep 2 doi: 10.1111/jog.15409. PMID: 36053141
Squamous cell carcinoma and osteosarcoma arising from a dermoid cyst--a case report and review of literature.
Allam-Nandyala P, Bui MM, Caracciolo JT, Hakam A
Int J Clin Exp Pathol 2010 Jan 10;3(3):313-8. PMID: 20224730Free PMC Article
Squamous cell carcinoma arising in a dermoid cyst of the ovary: a case series.
Hurwitz JL, Fenton A, McCluggage WG, McKenna S
BJOG 2007 Oct;114(10):1283-7. doi: 10.1111/j.1471-0528.2007.01478.x. PMID: 17877681
Malignancy associated with benign cystic teratomas (dermoid cysts) of the ovary.
Singh P, Yordan EL, Wilbanks GD, Miller AW, Wee A
Singapore Med J 1988 Feb;29(1):30-4. PMID: 2841767
Hypercalcemia associated with epidermoid carcinoma in ovarian cystic teratoma.
Kim W, Bockman R, Lemos L, Lewis JL Jr
Obstet Gynecol 1981 Jun;57(6 Suppl):81S-5S. PMID: 7243131

Clinical prediction guides

Malignant transformation of mature cystic teratoma of the ovary.
Atwi D, Kamal M, Quinton M, Hassell LA
J Obstet Gynaecol Res 2022 Dec;48(12):3068-3076. Epub 2022 Sep 2 doi: 10.1111/jog.15409. PMID: 36053141
Extramammary Paget's disease arising in mature cystic teratoma of the ovary.
Shimizu S, Kobayashi H, Suchi T, Torii Y, Narita K, Aoki S
Am J Surg Pathol 1991 Oct;15(10):1002-6. doi: 10.1097/00000478-199110000-00011. PMID: 1718175
Krukenberg tumors of the ovary: a clinicopathologic analysis of 112 cases.
Yakushiji M, Tazaki T, Nishimura H, Kato T
Nihon Sanka Fujinka Gakkai Zasshi 1987 Mar;39(3):479-85. PMID: 3031182
Pathogenesis of teratoid tumors of the ovary and testis.
Mulligan RM
Pathol Annu 1975;10:271-98. PMID: 1101172

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