U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Ovarian primitive germ cell tumor

MedGen UID:
275291
•Concept ID:
C1518727
•
Neoplastic Process
Synonyms: Ovarian Primitive Germ Cell Tumor; ovarian primitive germ cell tumor
 
Monarch Initiative: MONDO:0003408

Definition

A malignant tumor that arises from the ovary and is characterized by the presence of malignant germ cell components but lacks a teratoma component. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVOvarian primitive germ cell tumor

Professional guidelines

PubMed

Clinical Challenges in the Management of Malignant Ovarian Germ Cell Tumours.
Saani I, Raj N, Sood R, Ansari S, Mandviwala HA, Sanchez E, Boussios S
Int J Environ Res Public Health 2023 Jun 9;20(12) doi: 10.3390/ijerph20126089. PMID: 37372675Free PMC Article
DICER1-associated Tumors in the Female Genital Tract: Molecular Basis, Clinicopathologic Features, and Differential Diagnosis.
Han LM, Weiel JJ, Longacre TA, Folkins AK
Adv Anat Pathol 2022 Sep 1;29(5):297-308. Epub 2022 Jul 1 doi: 10.1097/PAP.0000000000000351. PMID: 35778792
DICER1 syndrome: clarifying the diagnosis, clinical features and management implications of a pleiotropic tumour predisposition syndrome.
Slade I, Bacchelli C, Davies H, Murray A, Abbaszadeh F, Hanks S, Barfoot R, Burke A, Chisholm J, Hewitt M, Jenkinson H, King D, Morland B, Pizer B, Prescott K, Saggar A, Side L, Traunecker H, Vaidya S, Ward P, Futreal PA, Vujanic G, Nicholson AG, Sebire N, Turnbull C, Priest JR, Pritchard-Jones K, Houlston R, Stiller C, Stratton MR, Douglas J, Rahman N
J Med Genet 2011 Apr;48(4):273-8. Epub 2011 Jan 25 doi: 10.1136/jmg.2010.083790. PMID: 21266384

Recent clinical studies

Etiology

Clinical Challenges in the Management of Malignant Ovarian Germ Cell Tumours.
Saani I, Raj N, Sood R, Ansari S, Mandviwala HA, Sanchez E, Boussios S
Int J Environ Res Public Health 2023 Jun 9;20(12) doi: 10.3390/ijerph20126089. PMID: 37372675Free PMC Article
Germ Cell Tumors of the Female Genital Tract.
Euscher ED
Surg Pathol Clin 2019 Jun;12(2):621-649. doi: 10.1016/j.path.2019.01.005. PMID: 31097117
Rapidly progressing central-type primitive neuroectodermal tumor of the ovary: a case report.
Mize B, Salame G, Maglantay R, Chen NN, Lee YC
Eur J Gynaecol Oncol 2017;38(2):290-293. PMID: 29953798
Germ cell tumors of the ovary: an update.
Nogales FF, Dulcey I, Preda O
Arch Pathol Lab Med 2014 Mar;138(3):351-62. doi: 10.5858/arpa.2012-0547-RA. PMID: 24576031
Germ cell tumours.
Talerman A
Ann Pathol 1985;5(3):145-57. PMID: 3000396

Diagnosis

Clinical Challenges in the Management of Malignant Ovarian Germ Cell Tumours.
Saani I, Raj N, Sood R, Ansari S, Mandviwala HA, Sanchez E, Boussios S
Int J Environ Res Public Health 2023 Jun 9;20(12) doi: 10.3390/ijerph20126089. PMID: 37372675Free PMC Article
Malignant Germ Cell Tumors of the Ovary: Clinical and Imaging Features.
Rogers D, Menias C, Shaaban A
Radiol Clin North Am 2023 Jul;61(4):579-594. Epub 2023 Apr 3 doi: 10.1016/j.rcl.2023.02.004. PMID: 37169425
Ovarian Primitive Neuroectodermal Tumor: Are You Central or Peripheral?
Bachert SE, Baldwin LA, Dueber JC, Piecoro DW
Int J Gynecol Pathol 2022 Mar 1;41(2):203-205. doi: 10.1097/PGP.0000000000000789. PMID: 33852507
Germ Cell Tumors of the Female Genital Tract.
Euscher ED
Surg Pathol Clin 2019 Jun;12(2):621-649. doi: 10.1016/j.path.2019.01.005. PMID: 31097117
Neuroectodermal ovarian tumors: a brief overview.
Morovic A, Damjanov I
Histol Histopathol 2008 Jun;23(6):765-71. doi: 10.14670/HH-23.765. PMID: 18366014

Therapy

Pediatric growing teratoma syndrome of the ovary: A case report and review of the literature.
Oyama T, Noda T, Washio K, Shimada A
Medicine (Baltimore) 2020 Sep 18;99(38):e22297. doi: 10.1097/MD.0000000000022297. PMID: 32957389Free PMC Article
Ovarian malignant germ cell tumors: cellular classification and clinical and imaging features.
Shaaban AM, Rezvani M, Elsayes KM, Baskin H Jr, Mourad A, Foster BR, Jarboe EA, Menias CO
Radiographics 2014 May-Jun;34(3):777-801. doi: 10.1148/rg.343130067. PMID: 24819795
A rare primitive neuroectodermal tumour presenting unusually in a postmenopausal woman.
Doshi J, Doshi S, Disu SA, Sanusi F
J Obstet Gynaecol 2003 Nov;23(6):684-5. doi: 10.1080/01443610310001609579. PMID: 14617490
Current approaches to diagnosis and treatment of ovarian germ cell malignancies.
Fishman DA, Schwartz PE
Curr Opin Obstet Gynecol 1994 Feb;6(1):98-104. PMID: 8180359
Embryonal carcinoma of the ovary: a six-year survival.
Ueda G, Abe Y, Yoshida M, Fujiwara T
Int J Gynaecol Obstet 1990 Mar;31(3):287-92. doi: 10.1016/0020-7292(90)91025-l. PMID: 1690671

Prognosis

Ovarian tumors: a survey of selected advances of note during the life of this journal.
Young RH
Hum Pathol 2020 Jan;95:169-206. Epub 2019 Oct 22 doi: 10.1016/j.humpath.2019.09.002. PMID: 31654691
Ovarian primary primitive neuroectodermal tumor: a review of cases at PUMCH and in the published literature.
Chao X, Bi Y, Li L
Orphanet J Rare Dis 2019 Jun 19;14(1):147. doi: 10.1186/s13023-019-1106-5. PMID: 31217017Free PMC Article
Discovery and diagnostic value of a novel oncofetal protein: glypican 3.
Wang SK, Zynger DL, Hes O, Yang XJ
Adv Anat Pathol 2014 Nov;21(6):450-60. doi: 10.1097/PAP.0000000000000043. PMID: 25299314
Ovarian malignant germ cell tumors: cellular classification and clinical and imaging features.
Shaaban AM, Rezvani M, Elsayes KM, Baskin H Jr, Mourad A, Foster BR, Jarboe EA, Menias CO
Radiographics 2014 May-Jun;34(3):777-801. doi: 10.1148/rg.343130067. PMID: 24819795
Neuroectodermal ovarian tumors: a brief overview.
Morovic A, Damjanov I
Histol Histopathol 2008 Jun;23(6):765-71. doi: 10.14670/HH-23.765. PMID: 18366014

Clinical prediction guides

Uncommon Metastasis of Ovarian Dysgerminoma: A Case Report and Review of the Literature.
Tîrnovanu MC, Florea ID, Tănase A, Toma BF, Cojocaru E, Ungureanu C, Lozneanu L
Medicina (Kaunas) 2021 May 27;57(6) doi: 10.3390/medicina57060534. PMID: 34071828Free PMC Article
Ovarian tumors: a survey of selected advances of note during the life of this journal.
Young RH
Hum Pathol 2020 Jan;95:169-206. Epub 2019 Oct 22 doi: 10.1016/j.humpath.2019.09.002. PMID: 31654691
Discovery and diagnostic value of a novel oncofetal protein: glypican 3.
Wang SK, Zynger DL, Hes O, Yang XJ
Adv Anat Pathol 2014 Nov;21(6):450-60. doi: 10.1097/PAP.0000000000000043. PMID: 25299314
Spectrum of germ cell tumors: from head to toe.
Ueno T, Tanaka YO, Nagata M, Tsunoda H, Anno I, Ishikawa S, Kawai K, Itai Y
Radiographics 2004 Mar-Apr;24(2):387-404. doi: 10.1148/rg.242035082. PMID: 15026588
Germ cell tumours.
Talerman A
Ann Pathol 1985;5(3):145-57. PMID: 3000396

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...