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Testicular Mixed Embryonal Carcinoma and Teratoma

MedGen UID:
277812
•Concept ID:
C1336716
•
Neoplastic Process
Synonyms: Mixed Embryonal Carcinoma and Teratoma of Testis; Mixed Embryonal Carcinoma and Teratoma of the Testis

Definition

A malignant mixed germ cell tumor arising from the testis, characterized by the presence of an embryonal carcinomatous component and a teratomatous component. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVTesticular Mixed Embryonal Carcinoma and Teratoma

Professional guidelines

PubMed

Germ cell tumors of the gonads: a selective review emphasizing problems in differential diagnosis, newly appreciated, and controversial issues.
Ulbright TM
Mod Pathol 2005 Feb;18 Suppl 2:S61-79. doi: 10.1038/modpathol.3800310. PMID: 15761467
The treatment of cranial germ cell tumours.
Brandes AA, Pasetto LM, Monfardini S
Cancer Treat Rev 2000 Aug;26(4):233-42. doi: 10.1053/ctrv.2000.0169. PMID: 10913379
Lymphadenectomy combined with preoperative and postoperative cobalt 60 teletherapy in the management of embryonal carcinoma and teratocarcinoma of the testis.
Nicholson TC, Walsh PC, Rotner MB
J Urol 1974 Jul;112(1):109-10. doi: 10.1016/s0022-5347(17)59654-8. PMID: 4858107

Recent clinical studies

Etiology

Clinical Features and Survival Outcomes in Children and Adolescents With Malignant Mediastinal Germ Cell Tumors Based on Surveillance, Epidemiology, and End Results Database Analysis.
Wu P, Yang Y, Yu Z, Zhao L, Feng S
J Surg Res 2023 Aug;288:362-371. Epub 2023 Apr 14 doi: 10.1016/j.jss.2023.03.018. PMID: 37062232
Paclitaxel, bleomycin, etoposide, and cisplatin (T-BEP) as initial treatment in patients with poor-prognosis germ cell tumors (GCT): a phase II study.
Mardiak J, Sálek T, Sycová-Milá Z, Obertová J, Recková M, Mego M, Hlavatá Z, Brozmanová K, Risnyovzská Z, Svetlovská D, Koza I
Neoplasma 2007;54(3):240-5. PMID: 17447857
Sentinel lymph node imaging using quantum dots in mouse tumor models.
Ballou B, Ernst LA, Andreko S, Harper T, Fitzpatrick JA, Waggoner AS, Bruchez MP
Bioconjug Chem 2007 Mar-Apr;18(2):389-96. Epub 2007 Jan 31 doi: 10.1021/bc060261j. PMID: 17263568
Retinoids in bladder, testis and prostate cancer: epidemiologic, pre-clinical and clinical observations.
Trump DL
Leukemia 1994;8 Suppl 3:S50-4. PMID: 7808025
New globoseries glycosphingolipids in human teratocarcinoma reactive with the monoclonal antibody directed to a developmentally regulated antigen, stage-specific embryonic antigen 3.
Kannagi R, Levery SB, Ishigami F, Hakomori S, Shevinsky LH, Knowles BB, Solter D
J Biol Chem 1983 Jul 25;258(14):8934-42. PMID: 6863318

Diagnosis

The HERV-K accessory protein Np9 controls viability and migration of teratocarcinoma cells.
Chan SM, Sapir T, Park SS, Rual JF, Contreras-Galindo R, Reiner O, Markovitz DM
PLoS One 2019;14(2):e0212970. Epub 2019 Feb 28 doi: 10.1371/journal.pone.0212970. PMID: 30818388Free PMC Article
Perspectives on testicular germ cell neoplasms.
Cheng L, Lyu B, Roth LM
Hum Pathol 2017 Jan;59:10-25. Epub 2016 Aug 26 doi: 10.1016/j.humpath.2016.08.002. PMID: 27569298
Testicular teratocarcinoma associated with testicular microlithiasis.
Elmali M, Koprulu C, Ceyhan M, Yildiz L
Abdom Imaging 2008 Mar-Apr;33(2):244-6. doi: 10.1007/s00261-007-9238-9. PMID: 17464445
Testis-specific HMG-domain protein alters the responses of cells to cisplatin.
Zamble DB, Mikata Y, Eng CH, Sandman KE, Lippard SJ
J Inorg Biochem 2002 Aug 30;91(3):451-62. doi: 10.1016/s0162-0134(02)00472-5. PMID: 12175937
Testicular sonogram.
Devkota J, White S
J Natl Med Assoc 1980 Aug;72(8):806-11. PMID: 7401191Free PMC Article

Therapy

Paclitaxel, bleomycin, etoposide, and cisplatin (T-BEP) as initial treatment in patients with poor-prognosis germ cell tumors (GCT): a phase II study.
Mardiak J, Sálek T, Sycová-Milá Z, Obertová J, Recková M, Mego M, Hlavatá Z, Brozmanová K, Risnyovzská Z, Svetlovská D, Koza I
Neoplasma 2007;54(3):240-5. PMID: 17447857
Retinoids in bladder, testis and prostate cancer: epidemiologic, pre-clinical and clinical observations.
Trump DL
Leukemia 1994;8 Suppl 3:S50-4. PMID: 7808025
Total parenteral nutrition as an adjuvant to patients undergoing chemotherapy for testicular carcinoma: protection of body composition--a randomized, prospective study.
Drott C, Unsgaard B, Scherstén T, Lundholm K
Surgery 1988 May;103(5):499-506. PMID: 2452491
Iatrogenic internal hernia involving the iliac artery.
Guba AM Jr, Lough F, Collins GJ, Feaster M, Rich NM
Ann Surg 1978 Jul;188(1):49-52. doi: 10.1097/00000658-197807000-00008. PMID: 666377Free PMC Article
Lymphadenectomy combined with preoperative and postoperative cobalt 60 teletherapy in the management of embryonal carcinoma and teratocarcinoma of the testis.
Nicholson TC, Walsh PC, Rotner MB
J Urol 1974 Jul;112(1):109-10. doi: 10.1016/s0022-5347(17)59654-8. PMID: 4858107

Prognosis

The HERV-K accessory protein Np9 controls viability and migration of teratocarcinoma cells.
Chan SM, Sapir T, Park SS, Rual JF, Contreras-Galindo R, Reiner O, Markovitz DM
PLoS One 2019;14(2):e0212970. Epub 2019 Feb 28 doi: 10.1371/journal.pone.0212970. PMID: 30818388Free PMC Article
Perspectives on testicular germ cell neoplasms.
Cheng L, Lyu B, Roth LM
Hum Pathol 2017 Jan;59:10-25. Epub 2016 Aug 26 doi: 10.1016/j.humpath.2016.08.002. PMID: 27569298
Unusual autopsy finding in a case of metastatic teratocarcinoma.
Nath P, Bhattacharya S, Bharadwaj R
Cardiovasc Pathol 2011 Nov-Dec;20(6):384-5. Epub 2010 Dec 15 doi: 10.1016/j.carpath.2010.09.004. PMID: 21109467
Further practical experiences in the recognition and management of carcinoma in situ of the testis.
Mumperow E, Lauke H, Holstein AF, Hartmann M
Urol Int 1992;48(2):162-6. doi: 10.1159/000282322. PMID: 1374974
New globoseries glycosphingolipids in human teratocarcinoma reactive with the monoclonal antibody directed to a developmentally regulated antigen, stage-specific embryonic antigen 3.
Kannagi R, Levery SB, Ishigami F, Hakomori S, Shevinsky LH, Knowles BB, Solter D
J Biol Chem 1983 Jul 25;258(14):8934-42. PMID: 6863318

Clinical prediction guides

Perspectives on testicular germ cell neoplasms.
Cheng L, Lyu B, Roth LM
Hum Pathol 2017 Jan;59:10-25. Epub 2016 Aug 26 doi: 10.1016/j.humpath.2016.08.002. PMID: 27569298
Vasculogenesis and angiogenesis in nonseminomatous testicular germ cell tumors.
Silván U, Díez-Torre A, Bonilla Z, Moreno P, Díaz-Núñez M, Aréchaga J
Urol Oncol 2015 Jun;33(6):268.e17-28. Epub 2015 Mar 12 doi: 10.1016/j.urolonc.2015.01.005. PMID: 25772688
Surrounding cells affect the gene expression pattern of human beta-defensins in squamous cell carcinoma in vitro.
Kida-Takaoka S, Yamaai T, Mizukawa N, Murakami J, Iida S
Anticancer Res 2014 Nov;34(11):6443-9. PMID: 25368244
Clinical outcomes of patients with nonseminomatous germ cell tumours and negative postchemotherapy positron emission tomography.
Buchler T, Simonova K, Fencl P, Jarkovsky J, Abrahamova J
Cancer Invest 2012 Jul;30(6):487-92. Epub 2012 Apr 17 doi: 10.3109/07357907.2012.679347. PMID: 22506657
Paclitaxel, bleomycin, etoposide, and cisplatin (T-BEP) as initial treatment in patients with poor-prognosis germ cell tumors (GCT): a phase II study.
Mardiak J, Sálek T, Sycová-Milá Z, Obertová J, Recková M, Mego M, Hlavatá Z, Brozmanová K, Risnyovzská Z, Svetlovská D, Koza I
Neoplasma 2007;54(3):240-5. PMID: 17447857

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