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Larynx cancer

MedGen UID:
2868
•Concept ID:
C0007107
•
Neoplastic Process
Synonym: Laryngeal cancer
SNOMED CT: CA - Cancer of larynx (363429002); Laryngeal cancer (363429002); Cancer of larynx (363429002); Malignant tumor of larynx (363429002)
 
Monarch Initiative: MONDO:0002352

Definition

A primary or metastatic malignant neoplasm involving the larynx. The majority are carcinomas. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLarynx cancer

Professional guidelines

PubMed

The Changing Demographics and Treatment of Larynx Cancer.
Han J, Sumer BD
Ann Surg Oncol 2021 Nov;28(12):6927-6928. Epub 2021 Aug 24 doi: 10.1245/s10434-021-10657-z. PMID: 34431018
Reply to Letter to the Editor regarding "Treatment modality and outcomes in larynx cancer patients: A sex-based evaluation".
Kejner AE, Li H, Li EY, Porterfield JZ
Head Neck 2020 Aug;42(8):2226-2228. Epub 2020 Jun 8 doi: 10.1002/hed.26156. PMID: 32511828
Transoral and Transcervical Surgical Innovations in the Treatment of Glottic Cancer.
Zeitels SM
Otolaryngol Clin North Am 2015 Aug;48(4):677-85. doi: 10.1016/j.otc.2015.04.012. PMID: 26233792

Curated

NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®), Head and Neck Cancers, 2024

Recent clinical studies

Etiology

Updates on Larynx Cancer: Risk Factors and Oncogenesis.
Liberale C, Soloperto D, Marchioni A, Monzani D, Sacchetto L
Int J Mol Sci 2023 Aug 18;24(16) doi: 10.3390/ijms241612913. PMID: 37629093Free PMC Article
Global, regional, and national burden of respiratory tract cancers and associated risk factors from 1990 to 2019: a systematic analysis for the Global Burden of Disease Study 2019.
GBD 2019 Respiratory Tract Cancers Collaborators
Lancet Respir Med 2021 Sep;9(9):1030-1049. Epub 2021 Aug 16 doi: 10.1016/S2213-2600(21)00164-8. PMID: 34411511Free PMC Article
Association of Oral Microbiome With Risk for Incident Head and Neck Squamous Cell Cancer.
Hayes RB, Ahn J, Fan X, Peters BA, Ma Y, Yang L, Agalliu I, Burk RD, Ganly I, Purdue MP, Freedman ND, Gapstur SM, Pei Z
JAMA Oncol 2018 Mar 1;4(3):358-365. doi: 10.1001/jamaoncol.2017.4777. PMID: 29327043Free PMC Article
An update on larynx cancer.
Steuer CE, El-Deiry M, Parks JR, Higgins KA, Saba NF
CA Cancer J Clin 2017 Jan;67(1):31-50. Epub 2016 Nov 29 doi: 10.3322/caac.21386. PMID: 27898173
Long-term results of RTOG 91-11: a comparison of three nonsurgical treatment strategies to preserve the larynx in patients with locally advanced larynx cancer.
Forastiere AA, Zhang Q, Weber RS, Maor MH, Goepfert H, Pajak TF, Morrison W, Glisson B, Trotti A, Ridge JA, Thorstad W, Wagner H, Ensley JF, Cooper JS
J Clin Oncol 2013 Mar 1;31(7):845-52. Epub 2012 Nov 26 doi: 10.1200/JCO.2012.43.6097. PMID: 23182993Free PMC Article

Diagnosis

A Systematic Review Evaluating the Diagnostic Efficacy of Narrow-Band Imaging for Laryngeal Cancer Detection.
Sanda IA, Hainarosie R, Ionita IG, Voiosu C, Ristea MR, Zamfir Chiru Anton A
Medicina (Kaunas) 2024 Jul 25;60(8) doi: 10.3390/medicina60081205. PMID: 39202487Free PMC Article
Head and Neck Cancer Incidence in the United States Before and During the COVID-19 Pandemic.
Semprini J, Pagedar NA, Boakye EA, Osazuwa-Peters N
JAMA Otolaryngol Head Neck Surg 2024 Mar 1;150(3):193-200. doi: 10.1001/jamaoto.2023.4322. PMID: 38206603Free PMC Article
125 years of head and neck radiotherapy: could organ-sparing radiotherapy of larynx cancer have prevented World War I?
Brunner TB, Wördehoff H, Gawish A, Busch U
Strahlenther Onkol 2022 Apr;198(4):325-333. Epub 2022 Feb 11 doi: 10.1007/s00066-022-01902-9. PMID: 35147735Free PMC Article
An update on larynx cancer.
Steuer CE, El-Deiry M, Parks JR, Higgins KA, Saba NF
CA Cancer J Clin 2017 Jan;67(1):31-50. Epub 2016 Nov 29 doi: 10.3322/caac.21386. PMID: 27898173
MiR-221 as a pre- and postoperative plasma biomarker for larynx cancer patients.
Yilmaz SS, Guzel E, Karatas OF, Yilmaz M, Creighton CJ, Ozen M
Laryngoscope 2015 Dec;125(12):E377-81. Epub 2015 May 6 doi: 10.1002/lary.25332. PMID: 25945817

Therapy

Updates on Larynx Cancer: Risk Factors and Oncogenesis.
Liberale C, Soloperto D, Marchioni A, Monzani D, Sacchetto L
Int J Mol Sci 2023 Aug 18;24(16) doi: 10.3390/ijms241612913. PMID: 37629093Free PMC Article
Radiotherapy for laryngeal cancers.
Biau J, Pointreau Y, Blanchard P, Khampan C, Giraud P, Lapeyre M, Maingon P
Cancer Radiother 2022 Feb-Apr;26(1-2):206-212. Epub 2021 Dec 22 doi: 10.1016/j.canrad.2021.09.004. PMID: 34953705
Decision making in advanced larynx cancer: An evidenced based review.
Eskander A, Blakaj DM, Dziegielewski PT
Oral Oncol 2018 Nov;86:195-199. Epub 2018 Oct 1 doi: 10.1016/j.oraloncology.2018.09.019. PMID: 30409301
Transoral and Transcervical Surgical Innovations in the Treatment of Glottic Cancer.
Zeitels SM
Otolaryngol Clin North Am 2015 Aug;48(4):677-85. doi: 10.1016/j.otc.2015.04.012. PMID: 26233792
Long-term results of RTOG 91-11: a comparison of three nonsurgical treatment strategies to preserve the larynx in patients with locally advanced larynx cancer.
Forastiere AA, Zhang Q, Weber RS, Maor MH, Goepfert H, Pajak TF, Morrison W, Glisson B, Trotti A, Ridge JA, Thorstad W, Wagner H, Ensley JF, Cooper JS
J Clin Oncol 2013 Mar 1;31(7):845-52. Epub 2012 Nov 26 doi: 10.1200/JCO.2012.43.6097. PMID: 23182993Free PMC Article

Prognosis

Global, regional, and national burden of respiratory tract cancers and associated risk factors from 1990 to 2019: a systematic analysis for the Global Burden of Disease Study 2019.
GBD 2019 Respiratory Tract Cancers Collaborators
Lancet Respir Med 2021 Sep;9(9):1030-1049. Epub 2021 Aug 16 doi: 10.1016/S2213-2600(21)00164-8. PMID: 34411511Free PMC Article
Age-specific larynx cancer incidence rate in the world.
Charvat H, Saito E
Jpn J Clin Oncol 2021 Jul 1;51(7):1181-1182. doi: 10.1093/jjco/hyab097. PMID: 34136911
An update on larynx cancer.
Steuer CE, El-Deiry M, Parks JR, Higgins KA, Saba NF
CA Cancer J Clin 2017 Jan;67(1):31-50. Epub 2016 Nov 29 doi: 10.3322/caac.21386. PMID: 27898173
Laryngeal Verrucous Carcinoma.
Echanique KA, Desai SV, Marchiano E, Spinazzi EF, Strojan P, Baredes S, Eloy JA
Otolaryngol Head Neck Surg 2017 Jan;156(1):38-45. Epub 2016 Aug 9 doi: 10.1177/0194599816662631. PMID: 27484231
Long-term results of RTOG 91-11: a comparison of three nonsurgical treatment strategies to preserve the larynx in patients with locally advanced larynx cancer.
Forastiere AA, Zhang Q, Weber RS, Maor MH, Goepfert H, Pajak TF, Morrison W, Glisson B, Trotti A, Ridge JA, Thorstad W, Wagner H, Ensley JF, Cooper JS
J Clin Oncol 2013 Mar 1;31(7):845-52. Epub 2012 Nov 26 doi: 10.1200/JCO.2012.43.6097. PMID: 23182993Free PMC Article

Clinical prediction guides

Predictors of multiple dilations and functional outcomes after total laryngectomy and laryngopharyngectomy.
Cortina LE, Wu MP, Meyer CD, Feng AL, Varvares MA, Richmon JD, Deschler DG, Lin DT
Head Neck 2024 Jan;46(1):138-144. Epub 2023 Oct 31 doi: 10.1002/hed.27545. PMID: 37908173
Biomarkers of laryngeal squamous cell carcinoma: a review.
Cavaliere M, Bisogno A, Scarpa A, D'Urso A, Marra P, Colacurcio V, De Luca P, Ralli M, Cassandro E, Cassandro C
Ann Diagn Pathol 2021 Oct;54:151787. Epub 2021 Jul 2 doi: 10.1016/j.anndiagpath.2021.151787. PMID: 34242969
Association of Oral Microbiome With Risk for Incident Head and Neck Squamous Cell Cancer.
Hayes RB, Ahn J, Fan X, Peters BA, Ma Y, Yang L, Agalliu I, Burk RD, Ganly I, Purdue MP, Freedman ND, Gapstur SM, Pei Z
JAMA Oncol 2018 Mar 1;4(3):358-365. doi: 10.1001/jamaoncol.2017.4777. PMID: 29327043Free PMC Article
An update on larynx cancer.
Steuer CE, El-Deiry M, Parks JR, Higgins KA, Saba NF
CA Cancer J Clin 2017 Jan;67(1):31-50. Epub 2016 Nov 29 doi: 10.3322/caac.21386. PMID: 27898173
Occupation and cancer of the larynx: a systematic review and meta-analysis.
Bayer O, Cámara R, Zeissig SR, Ressing M, Dietz A, Locati LD, Ramroth H, Singer S
Eur Arch Otorhinolaryngol 2016 Jan;273(1):9-20. Epub 2014 Oct 14 doi: 10.1007/s00405-014-3321-y. PMID: 25311307

Recent systematic reviews

A Systematic Review Evaluating the Diagnostic Efficacy of Narrow-Band Imaging for Laryngeal Cancer Detection.
Sanda IA, Hainarosie R, Ionita IG, Voiosu C, Ristea MR, Zamfir Chiru Anton A
Medicina (Kaunas) 2024 Jul 25;60(8) doi: 10.3390/medicina60081205. PMID: 39202487Free PMC Article
The application of radiomics in laryngeal cancer.
Rajgor AD, Patel S, McCulloch D, Obara B, Bacardit J, McQueen A, Aboagye E, Ali T, O'Hara J, Hamilton DW
Br J Radiol 2021 Dec;94(1128):20210499. Epub 2021 Sep 29 doi: 10.1259/bjr.20210499. PMID: 34586899Free PMC Article
Global, regional, and national burden of respiratory tract cancers and associated risk factors from 1990 to 2019: a systematic analysis for the Global Burden of Disease Study 2019.
GBD 2019 Respiratory Tract Cancers Collaborators
Lancet Respir Med 2021 Sep;9(9):1030-1049. Epub 2021 Aug 16 doi: 10.1016/S2213-2600(21)00164-8. PMID: 34411511Free PMC Article
Laryngeal Verrucous Carcinoma.
Echanique KA, Desai SV, Marchiano E, Spinazzi EF, Strojan P, Baredes S, Eloy JA
Otolaryngol Head Neck Surg 2017 Jan;156(1):38-45. Epub 2016 Aug 9 doi: 10.1177/0194599816662631. PMID: 27484231
Occupation and cancer of the larynx: a systematic review and meta-analysis.
Bayer O, Cámara R, Zeissig SR, Ressing M, Dietz A, Locati LD, Ramroth H, Singer S
Eur Arch Otorhinolaryngol 2016 Jan;273(1):9-20. Epub 2014 Oct 14 doi: 10.1007/s00405-014-3321-y. PMID: 25311307

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
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      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Curated

    • NCCN, 2024
      NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®), Head and Neck Cancers, 2024

    Consumer resources

    Reviews

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