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Invasive hydatidiform mole

MedGen UID:
3055
•Concept ID:
C0008493
•
Neoplastic Process
Synonyms: Chorioadenoma; Chorioadenomas; Hydatidiform Mole, Invasive; Hydatidiform Moles, Invasive; Invasive Hydatidiform Mole; Invasive Hydatidiform Moles; Invasive Mole; Invasive Moles; Mole, Invasive; Mole, Invasive Hydatidiform; Moles, Invasive; Moles, Invasive Hydatidiform
SNOMED CT: Invasive hydatidiform mole (416669000); Chorioadenoma (416669000); Chorioadenoma destruens (416669000); IM - Invasive mole (416669000); Invasive mole (416669000); Invasive mole - placenta (416669000); Invasive hydatidiform mole (18799007); Malignant hydatidiform mole (18799007); Chorioadenoma destruens (18799007); Chorioadenoma (18799007); Invasive mole (18799007)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
•Concept ID:
CN307044
•
Finding
Source: Orphanet
clinical entity without genetic inheritance.
See: This record
Not genetically inherited (Orphanet)
 
Monarch Initiative: MONDO:0020549
Orphanet: ORPHA99925

Definition

A form of gestational trophoblastic neoplasia similar to a hydatidiform mole but with deep invasion into the myometriumand histologically characterized hyperplasia of trophoblasts, generalized cystic degeneration of chorionic villi and the presence of molar villi in the myometrium and/ or uterine blood vessels. Indicative signs include persistent unexplained metrorrhagia or secondary increase, stagnation, or non-normalization at 6 months of total serum chorionic gonadotropin (hCG) levels after evacuation of a hydatidiform mole. Metastases (in the lungs or vagina) may be observed. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVInvasive hydatidiform mole

Professional guidelines

PubMed

Gestational trophoblastic neoplasia: does centralization of care impact clinical management?
Mitric C, Yang K, Bhat G, Lheureux S, Laframboise S, Li X, Bouchard-Fortier G
Int J Gynecol Cancer 2023 Nov 6;33(11):1724-1732. doi: 10.1136/ijgc-2023-004526. PMID: 37723102
The pregnancy that wasn't: challenges of gestational trophoblastic neoplasia management in low- and middle-income countries.
Mburu A, Tonui P, Keitany K, Osborne RJ
Int J Gynecol Cancer 2022 Jul 4;32(7):944-948. doi: 10.1136/ijgc-2022-003569. PMID: 35788113
Combination chemotherapy for primary treatment of high-risk gestational trophoblastic tumour.
Deng L, Zhang J, Wu T, Lawrie TA
Cochrane Database Syst Rev 2013 Jan 31;2013(1):CD005196. doi: 10.1002/14651858.CD005196.pub4. PMID: 23440800Free PMC Article

Recent clinical studies

Etiology

Gestational trophoblastic diseases: recent advances in histopathologic diagnosis and related genetic aspects.
Hui P, Martel M, Parkash V
Adv Anat Pathol 2005 May;12(3):116-25. doi: 10.1097/01.pap.0000163960.11107.73. PMID: 15900112
Management of gestational trophoblastic diseases in Japan--a review.
Sasaki S
Placenta 2003 Apr;24 Suppl A:S28-32. doi: 10.1053/plac.2002.0933. PMID: 12842411
Placental site trophoblastic tumor. Diagnosis, clinical behavior and treatment.
Finkler NJ
J Reprod Med 1991 Jan;36(1):27-30. PMID: 1848895
Determinants of risk for developing invasive mole and choriocarcinoma following hydatidiform mole.
Hara T, Kaseki S, Tomoda Y, Nishikawa Y, Ishizuka T, Ishizuka N
Asia Oceania J Obstet Gynaecol 1986 Jun;12(2):241-50. doi: 10.1111/j.1447-0756.1986.tb00187.x. PMID: 3021093
Letter: Hydatidiform mole.
Dawood MY
Obstet Gynecol 1976 Feb;47(2):251-2. PMID: 175323

Diagnosis

Invasive Mole After Incomplete Miscarriage.
Habek D
Z Geburtshilfe Neonatol 2022 Aug;226(4):282. Epub 2022 Mar 9 doi: 10.1055/a-1742-3767. PMID: 35263771
Interstitial pregnancy mimicking an invasive hydatidiform mole.
Mittal S, Menon S
Am J Obstet Gynecol 2019 May;220(5):501. Epub 2018 Oct 25 doi: 10.1016/j.ajog.2018.10.024. PMID: 31079718
MRI of the placenta - a short review.
Dekan S, Linduska N, Kasprian G, Prayer D
Wien Med Wochenschr 2012 May;162(9-10):225-8. doi: 10.1007/s10354-012-0073-4. PMID: 22717878
Trophoblastic tumors--prognostic factors.
Jones WB
Cancer 1981 Jul 15;48(2 Suppl):602-7. doi: 10.1002/1097-0142(19810715)48:1+<602::aid-cncr2820481326>3.0.co;2-8. PMID: 6268287
CHORIOADENOMA DESTRUENS.
SPADEMAN LC, TUTTLE WM
Am J Obstet Gynecol 1964 Feb 15;88:549-50. doi: 10.1016/0002-9378(64)90517-4. PMID: 14123438

Therapy

Invasive mole.
Franke HR, Vermorken JB, von Kessel H, Dijkhuizen GH, Calame JJ, Stolk JG
Eur J Obstet Gynecol Reprod Biol 1986 Mar;21(3):181-5. doi: 10.1016/0028-2243(86)90034-1. PMID: 3007229
Invasive mole.
Lurain JR, Brewer JI
Semin Oncol 1982 Jun;9(2):174-80. PMID: 6289460
Trophoblastic tumors--prognostic factors.
Jones WB
Cancer 1981 Jul 15;48(2 Suppl):602-7. doi: 10.1002/1097-0142(19810715)48:1+<602::aid-cncr2820481326>3.0.co;2-8. PMID: 6268287
Letter: Hydatidiform mole.
Dawood MY
Obstet Gynecol 1976 Feb;47(2):251-2. PMID: 175323
Prophylactic chemotherapy of hydatidiform mole.
Kaku M
Am J Obstet Gynecol 1966 Jun 15;95(4):590-1. doi: 10.1016/0002-9378(66)90159-1. PMID: 4287225

Prognosis

Trophoblastic disease.
Tomoda Y, Ishizuka T, Goto S, Furuhashi Y
Curr Top Pathol 1992;85:203-31. doi: 10.1007/978-3-642-75941-3_7. PMID: 1321023
Study and treatment of gestational trophoblastic diseases at the John I. Brewer Trophoblastic Disease Center, 1962-1990.
Lurain JR, Sciarra JJ
Eur J Gynaecol Oncol 1991;12(6):425-8. PMID: 1667098
Determinants of risk for developing invasive mole and choriocarcinoma following hydatidiform mole.
Hara T, Kaseki S, Tomoda Y, Nishikawa Y, Ishizuka T, Ishizuka N
Asia Oceania J Obstet Gynaecol 1986 Jun;12(2):241-50. doi: 10.1111/j.1447-0756.1986.tb00187.x. PMID: 3021093
Trophoblastic tumors--prognostic factors.
Jones WB
Cancer 1981 Jul 15;48(2 Suppl):602-7. doi: 10.1002/1097-0142(19810715)48:1+<602::aid-cncr2820481326>3.0.co;2-8. PMID: 6268287
Letter: Hydatidiform mole.
Dawood MY
Obstet Gynecol 1976 Feb;47(2):251-2. PMID: 175323

Clinical prediction guides

Diagnostic Challenges in Invasive Mole With 18 F-FDG PET/CT.
Minami A, Nakamoto R, Shimamura T, Kitano Y, Nakamoto Y
Clin Nucl Med 2024 Dec 1;49(12):1148-1149. Epub 2024 Jul 22 doi: 10.1097/RLU.0000000000005378. PMID: 39045720
Pathology of gestational trophoblastic diseases.
Cheung AN
Best Pract Res Clin Obstet Gynaecol 2003 Dec;17(6):849-68. doi: 10.1016/s1521-6934(03)00094-4. PMID: 14614885
Management of gestational trophoblastic diseases in Japan--a review.
Sasaki S
Placenta 2003 Apr;24 Suppl A:S28-32. doi: 10.1053/plac.2002.0933. PMID: 12842411
Placental site trophoblastic tumor. Diagnosis, clinical behavior and treatment.
Finkler NJ
J Reprod Med 1991 Jan;36(1):27-30. PMID: 1848895
Anabolic steroids and bone marrow toxicity during therapy with methotrexate.
Rawbone RG, Bagshawe KD
Br J Cancer 1972 Oct;26(5):395-401. doi: 10.1038/bjc.1972.52. PMID: 4343678Free PMC Article

Recent systematic reviews

Invasive mole in a perimenopausal woman: a case report and systematic review.
von Welser SF, Grube M, Ortmann O
Arch Gynecol Obstet 2015 Dec;292(6):1193-9. Epub 2015 Jun 7 doi: 10.1007/s00404-015-3777-z. PMID: 26050078
Combination chemotherapy for primary treatment of high-risk gestational trophoblastic tumour.
Deng L, Zhang J, Wu T, Lawrie TA
Cochrane Database Syst Rev 2013 Jan 31;2013(1):CD005196. doi: 10.1002/14651858.CD005196.pub4. PMID: 23440800Free PMC Article

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