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Schizophrenia 6(SCZD6)

MedGen UID:
350380
•Concept ID:
C1864275
•
Disease or Syndrome
Synonyms: SCHIZOPHRENIA SUSCEPTIBILITY LOCUS, CHROMOSOME 8p-RELATED; SCZD6
 
Gene (location): NRG1 (8p12)
 
Monarch Initiative: MONDO:0011280
OMIM®: 603013

Definition

A schizophrenia that has material basis in an autosomal dominant mutation of SCZD6 on chromosome 8p21. [from MONDO]

Professional guidelines

PubMed

Augmentation of clozapine with amisulpride: an effective therapeutic strategy for violent treatment-resistant schizophrenia patients in a UK high-security hospital.
Hotham JE, Simpson PJ, Brooman-White RS, Basu A, Ross CC, Humphreys SA, Larkin F, Gupta N, Das M
CNS Spectr 2014 Oct;19(5):403-10. Epub 2013 Nov 28 doi: 10.1017/S1092852913000874. PMID: 24284256
Effectiveness of antipsychotic treatment for schizophrenia: 6-month results of the Pan-European Schizophrenia Outpatient Health Outcomes (SOHO) study.
Haro JM, Edgell ET, Novick D, Alonso J, Kennedy L, Jones PB, Ratcliffe M, Breier A; SOHO advisory board
Acta Psychiatr Scand 2005 Mar;111(3):220-31. doi: 10.1111/j.1600-0447.2004.00450.x. PMID: 15701107
The key-lock principle in the diagnosis and treatment of nonorganic insomnia related to psychiatric disorders: sleep laboratory investigations.
Saletu-Zyhlarz GM, Arnold O, Saletu B, Anderer P
Methods Find Exp Clin Pharmacol 2002;24 Suppl D:37-49. PMID: 12575467

Recent clinical studies

Etiology

Medial Frontal Cortex GABA Concentrations in Psychosis Spectrum and Mood Disorders: A Meta-analysis of Proton Magnetic Resonance Spectroscopy Studies.
Simmonite M, Steeby CJ, Taylor SF
Biol Psychiatry 2023 Jan 15;93(2):125-136. Epub 2022 Aug 17 doi: 10.1016/j.biopsych.2022.08.004. PMID: 36335069Free PMC Article
Assessment of Quality of Life 8-Dimension (AQoL-8D): translation, validation, and application in two Dutch trials in patients with epilepsy and schizophrenia.
Chan HY, Wijnen BFM, Hiligsmann M, Smit F, Leenen LAM, Majoie MHJM, Evers SMAA
Expert Rev Pharmacoecon Outcomes Res 2022 Jul;22(5):795-803. Epub 2021 Sep 26 doi: 10.1080/14737167.2021.1981861. PMID: 34553651Free PMC Article
Durable Cognitive Gains and Symptom Improvement Are Observed in Individuals With Recent-Onset Schizophrenia 6 Months After a Randomized Trial of Auditory Training Completed Remotely.
Loewy R, Fisher M, Ma S, Carter C, Ragland JD, Niendam TA, Stuart B, Schlosser D, Amirfathi F, Yohannes S, Vinogradov S
Schizophr Bull 2022 Jan 21;48(1):262-272. doi: 10.1093/schbul/sbab102. PMID: 34510196Free PMC Article
Clinical staging in severe mental disorders; bipolar disorder, depression and schizophrenia.
de la Fuente-Tomas L, Sánchez-Autet M, García-Álvarez L, González-Blanco L, Velasco Á, Sáiz Martínez PA, Garcia-Portilla MP, Bobes J
Rev Psiquiatr Salud Ment (Engl Ed) 2019 Apr-Jun;12(2):106-115. Epub 2018 Oct 9 doi: 10.1016/j.rpsm.2018.08.002. PMID: 30314812
Efficacy and safety of second-generation antipsychotics in children and adolescents with psychotic and bipolar spectrum disorders: comprehensive review of prospective head-to-head and placebo-controlled comparisons.
Fraguas D, Correll CU, Merchán-Naranjo J, Rapado-Castro M, Parellada M, Moreno C, Arango C
Eur Neuropsychopharmacol 2011 Aug;21(8):621-45. Epub 2010 Aug 10 doi: 10.1016/j.euroneuro.2010.07.002. PMID: 20702068

Diagnosis

Electroconvulsive therapy (ECT) and Psychiatric rehospitalization rates: a retrospective study.
Rahangdale A, Ferraro J
BMC Psychiatry 2024 Oct 30;24(1):753. doi: 10.1186/s12888-024-06211-2. PMID: 39478522Free PMC Article
Stability of schizophrenia diagnosis in a 10-year longitudinal study on first episode of non-affective psychosis: Conclusions from the PAFIP cohort.
Suárez-Pinilla P, Suárez-Pinilla M, Setién-Suero E, Ortiz-García de la Foz V, Mayoral-Van Son J, Vázquez-Bourgon J, Gómez-Revuelta M, Juncal-Ruíz M, Ayesa-Arriola R, Crespo-Facorro B
Acta Psychiatr Scand 2021 Oct;144(4):342-357. Epub 2021 Jul 21 doi: 10.1111/acps.13344. PMID: 34228812
The vicious circle of social exclusion and psychopathology: a systematic review of experimental ostracism research in psychiatric disorders.
Reinhard MA, Dewald-Kaufmann J, Wüstenberg T, Musil R, Barton BB, Jobst A, Padberg F
Eur Arch Psychiatry Clin Neurosci 2020 Aug;270(5):521-532. Epub 2019 Oct 4 doi: 10.1007/s00406-019-01074-1. PMID: 31586242
Schizophrenia is a later-onset feature of PCDH19 Girls Clustering Epilepsy.
Vlaskamp DRM, Bassett AS, Sullivan JE, Robblee J, Sadleir LG, Scheffer IE, Andrade DM
Epilepsia 2019 Mar;60(3):429-440. Epub 2019 Mar 3 doi: 10.1111/epi.14678. PMID: 30828795
Clinical staging in severe mental disorders; bipolar disorder, depression and schizophrenia.
de la Fuente-Tomas L, Sánchez-Autet M, García-Álvarez L, González-Blanco L, Velasco Á, Sáiz Martínez PA, Garcia-Portilla MP, Bobes J
Rev Psiquiatr Salud Ment (Engl Ed) 2019 Apr-Jun;12(2):106-115. Epub 2018 Oct 9 doi: 10.1016/j.rpsm.2018.08.002. PMID: 30314812

Therapy

The potential use of folate and its derivatives in treating psychiatric disorders: A systematic review.
Lam NSK, Long XX, Li X, Saad M, Lim F, Doery JC, Griffin RC, Galletly C
Biomed Pharmacother 2022 Feb;146:112541. Epub 2021 Dec 22 doi: 10.1016/j.biopha.2021.112541. PMID: 34953391
Assessment of Quality of Life 8-Dimension (AQoL-8D): translation, validation, and application in two Dutch trials in patients with epilepsy and schizophrenia.
Chan HY, Wijnen BFM, Hiligsmann M, Smit F, Leenen LAM, Majoie MHJM, Evers SMAA
Expert Rev Pharmacoecon Outcomes Res 2022 Jul;22(5):795-803. Epub 2021 Sep 26 doi: 10.1080/14737167.2021.1981861. PMID: 34553651Free PMC Article
Durable Cognitive Gains and Symptom Improvement Are Observed in Individuals With Recent-Onset Schizophrenia 6 Months After a Randomized Trial of Auditory Training Completed Remotely.
Loewy R, Fisher M, Ma S, Carter C, Ragland JD, Niendam TA, Stuart B, Schlosser D, Amirfathi F, Yohannes S, Vinogradov S
Schizophr Bull 2022 Jan 21;48(1):262-272. doi: 10.1093/schbul/sbab102. PMID: 34510196Free PMC Article
Efficacy and safety of second-generation antipsychotics in children and adolescents with psychotic and bipolar spectrum disorders: comprehensive review of prospective head-to-head and placebo-controlled comparisons.
Fraguas D, Correll CU, Merchán-Naranjo J, Rapado-Castro M, Parellada M, Moreno C, Arango C
Eur Neuropsychopharmacol 2011 Aug;21(8):621-45. Epub 2010 Aug 10 doi: 10.1016/j.euroneuro.2010.07.002. PMID: 20702068
Adverse behavioral events reported in patients taking alprazolam and other benzodiazepines.
Cole JO, Kando JC
J Clin Psychiatry 1993 Oct;54 Suppl:49-61; discussion 62-3. PMID: 8262890

Prognosis

Durable Cognitive Gains and Symptom Improvement Are Observed in Individuals With Recent-Onset Schizophrenia 6 Months After a Randomized Trial of Auditory Training Completed Remotely.
Loewy R, Fisher M, Ma S, Carter C, Ragland JD, Niendam TA, Stuart B, Schlosser D, Amirfathi F, Yohannes S, Vinogradov S
Schizophr Bull 2022 Jan 21;48(1):262-272. doi: 10.1093/schbul/sbab102. PMID: 34510196Free PMC Article
Totally Implantable Venous-Access Device in Maintenance Electroconvulsive Therapy: A Retrospective Case Series.
Macau E, Valero R, Gil-Badenes J, Valentí M, Baeza I, Pacchiarotti I, Bioque M
J ECT 2021 Jun 1;37(2):e9-e12. doi: 10.1097/YCT.0000000000000744. PMID: 34029306
The 15q11.2 BP1-BP2 Microdeletion (Burnside-Butler) Syndrome: In Silico Analyses of the Four Coding Genes Reveal Functional Associations with Neurodevelopmental Phenotypes.
Rafi SK, Butler MG
Int J Mol Sci 2020 May 6;21(9) doi: 10.3390/ijms21093296. PMID: 32384786Free PMC Article
Clinical staging in severe mental disorders; bipolar disorder, depression and schizophrenia.
de la Fuente-Tomas L, Sánchez-Autet M, García-Álvarez L, González-Blanco L, Velasco Á, Sáiz Martínez PA, Garcia-Portilla MP, Bobes J
Rev Psiquiatr Salud Ment (Engl Ed) 2019 Apr-Jun;12(2):106-115. Epub 2018 Oct 9 doi: 10.1016/j.rpsm.2018.08.002. PMID: 30314812
Absolute risk of suicide after first hospital contact in mental disorder.
Nordentoft M, Mortensen PB, Pedersen CB
Arch Gen Psychiatry 2011 Oct;68(10):1058-64. doi: 10.1001/archgenpsychiatry.2011.113. PMID: 21969462

Clinical prediction guides

Effects of an intervention program to improve mental health and epilepsy care in Madagascar.
Mioramalala S, Mroueh L, Bruand PE, Raharinivo MM, Rafanomezantsoa RM, Gérard D, Ratsimbasoa A, Preux PM, Boumédiène F
Compr Psychiatry 2024 Jul;132:152484. Epub 2024 Apr 10 doi: 10.1016/j.comppsych.2024.152484. PMID: 38626596
Durable Cognitive Gains and Symptom Improvement Are Observed in Individuals With Recent-Onset Schizophrenia 6 Months After a Randomized Trial of Auditory Training Completed Remotely.
Loewy R, Fisher M, Ma S, Carter C, Ragland JD, Niendam TA, Stuart B, Schlosser D, Amirfathi F, Yohannes S, Vinogradov S
Schizophr Bull 2022 Jan 21;48(1):262-272. doi: 10.1093/schbul/sbab102. PMID: 34510196Free PMC Article
The 15q11.2 BP1-BP2 Microdeletion (Burnside-Butler) Syndrome: In Silico Analyses of the Four Coding Genes Reveal Functional Associations with Neurodevelopmental Phenotypes.
Rafi SK, Butler MG
Int J Mol Sci 2020 May 6;21(9) doi: 10.3390/ijms21093296. PMID: 32384786Free PMC Article
Follow-up of subjects with suspected pre-psychotic state in Taiwan.
Liu CC, Lai MC, Liu CM, Chiu YN, Hsieh MH, Hwang TJ, Chien YL, Chen WJ, Hua MS, Hsiung PC, Huang YC, Hwu HG
Schizophr Res 2011 Mar;126(1-3):65-70. Epub 2010 Nov 26 doi: 10.1016/j.schres.2010.10.028. PMID: 21112187
Auditory P300 studies in schizophrenic subjects and their first degree relatives.
Black JL, Mowry BJ, Barton DA, De Roach JN
Australas Phys Eng Sci Med 1992 Jun;15(2):65-73. PMID: 1642573

Recent systematic reviews

The potential use of folate and its derivatives in treating psychiatric disorders: A systematic review.
Lam NSK, Long XX, Li X, Saad M, Lim F, Doery JC, Griffin RC, Galletly C
Biomed Pharmacother 2022 Feb;146:112541. Epub 2021 Dec 22 doi: 10.1016/j.biopha.2021.112541. PMID: 34953391
The vicious circle of social exclusion and psychopathology: a systematic review of experimental ostracism research in psychiatric disorders.
Reinhard MA, Dewald-Kaufmann J, Wüstenberg T, Musil R, Barton BB, Jobst A, Padberg F
Eur Arch Psychiatry Clin Neurosci 2020 Aug;270(5):521-532. Epub 2019 Oct 4 doi: 10.1007/s00406-019-01074-1. PMID: 31586242

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