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Intestinal Metaplasia of Columnar Epithelium

MedGen UID:
474253
•Concept ID:
C3272620
•
Finding

Definition

A morphologic finding indicating the replacement of part of the columnar epithelium by intestinal-type epithelium. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVIntestinal Metaplasia of Columnar Epithelium

Professional guidelines

PubMed

AGA Clinical Practice Update on Endoscopic Treatment of Barrett's Esophagus With Dysplasia and/or Early Cancer: Expert Review.
Sharma P, Shaheen NJ, Katzka D, Bergman JJGHM
Gastroenterology 2020 Feb;158(3):760-769. Epub 2019 Nov 12 doi: 10.1053/j.gastro.2019.09.051. PMID: 31730766
Barrett's oesophagus: epidemiology, diagnosis and clinical management.
Whiteman DC, Kendall BJ
Med J Aust 2016 Oct 3;205(7):317-24. doi: 10.5694/mja16.00796. PMID: 27681974
Subsquamous intestinal metaplasia: implications for endoscopic management of Barrett's esophagus.
Yachimski P, Falk GW
Clin Gastroenterol Hepatol 2012 Mar;10(3):220-4. Epub 2011 Oct 20 doi: 10.1016/j.cgh.2011.10.009. PMID: 22020059

Recent clinical studies

Etiology

Mechanisms and pathophysiology of Barrett oesophagus.
Souza RF, Spechler SJ
Nat Rev Gastroenterol Hepatol 2022 Sep;19(9):605-620. Epub 2022 Jun 7 doi: 10.1038/s41575-022-00622-w. PMID: 35672395
AGA Clinical Practice Update on Endoscopic Treatment of Barrett's Esophagus With Dysplasia and/or Early Cancer: Expert Review.
Sharma P, Shaheen NJ, Katzka D, Bergman JJGHM
Gastroenterology 2020 Feb;158(3):760-769. Epub 2019 Nov 12 doi: 10.1053/j.gastro.2019.09.051. PMID: 31730766
Barrett oesophagus.
Peters Y, Al-Kaabi A, Shaheen NJ, Chak A, Blum A, Souza RF, Di Pietro M, Iyer PG, Pech O, Fitzgerald RC, Siersema PD
Nat Rev Dis Primers 2019 May 23;5(1):35. doi: 10.1038/s41572-019-0086-z. PMID: 31123267
Pathogenesis and Cells of Origin of Barrett's Esophagus.
Que J, Garman KS, Souza RF, Spechler SJ
Gastroenterology 2019 Aug;157(2):349-364.e1. Epub 2019 May 10 doi: 10.1053/j.gastro.2019.03.072. PMID: 31082367Free PMC Article
Barrett's esophagus.
Spechler SJ
Semin Gastrointest Dis 1996 Apr;7(2):51-60. PMID: 8705259

Diagnosis

AGA Clinical Practice Update on Endoscopic Treatment of Barrett's Esophagus With Dysplasia and/or Early Cancer: Expert Review.
Sharma P, Shaheen NJ, Katzka D, Bergman JJGHM
Gastroenterology 2020 Feb;158(3):760-769. Epub 2019 Nov 12 doi: 10.1053/j.gastro.2019.09.051. PMID: 31730766
Barrett oesophagus.
Peters Y, Al-Kaabi A, Shaheen NJ, Chak A, Blum A, Souza RF, Di Pietro M, Iyer PG, Pech O, Fitzgerald RC, Siersema PD
Nat Rev Dis Primers 2019 May 23;5(1):35. doi: 10.1038/s41572-019-0086-z. PMID: 31123267
Pathogenesis and Cells of Origin of Barrett's Esophagus.
Que J, Garman KS, Souza RF, Spechler SJ
Gastroenterology 2019 Aug;157(2):349-364.e1. Epub 2019 May 10 doi: 10.1053/j.gastro.2019.03.072. PMID: 31082367Free PMC Article
Barrett's esophagus.
Spechler SJ
Semin Gastrointest Dis 1996 Apr;7(2):51-60. PMID: 8705259
The columnar-lined esophagus, intestinal metaplasia, and Norman Barrett.
Spechler SJ, Goyal RK
Gastroenterology 1996 Feb;110(2):614-21. doi: 10.1053/gast.1996.v110.agast960614. PMID: 8566611

Therapy

Hybrid Stomach-Intestinal Chromatin States Underlie Human Barrett's Metaplasia.
Singh H, Ha K, Hornick JL, Madha S, Cejas P, Jajoo K, Singh P, Polak P, Lee H, Shivdasani RA
Gastroenterology 2021 Sep;161(3):924-939.e11. Epub 2021 Jun 4 doi: 10.1053/j.gastro.2021.05.057. PMID: 34090884Free PMC Article
AGA Clinical Practice Update on Endoscopic Treatment of Barrett's Esophagus With Dysplasia and/or Early Cancer: Expert Review.
Sharma P, Shaheen NJ, Katzka D, Bergman JJGHM
Gastroenterology 2020 Feb;158(3):760-769. Epub 2019 Nov 12 doi: 10.1053/j.gastro.2019.09.051. PMID: 31730766
Barrett's esophagus: What do we need to know?
Mohy-Ud-Din N, Krill TS, Shah AR, Chatila AT, Singh S, Bilal M, Parupudi S
Dis Mon 2020 Jan;66(1):100850. Epub 2019 Feb 23 doi: 10.1016/j.disamonth.2019.02.003. PMID: 30808502
Possible application of trefoil factor family peptides in gastroesophageal reflux and Barrett's esophagus.
Fabisiak A, Bartoszek A, Kardas G, Fabisiak N, Fichna J
Peptides 2019 May;115:27-31. Epub 2019 Mar 1 doi: 10.1016/j.peptides.2019.02.007. PMID: 30831146
Natural history of Barrett's esophagus.
Milind R, Attwood SE
World J Gastroenterol 2012 Jul 21;18(27):3483-91. doi: 10.3748/wjg.v18.i27.3483. PMID: 22826612Free PMC Article

Prognosis

Barrett oesophagus.
Peters Y, Al-Kaabi A, Shaheen NJ, Chak A, Blum A, Souza RF, Di Pietro M, Iyer PG, Pech O, Fitzgerald RC, Siersema PD
Nat Rev Dis Primers 2019 May 23;5(1):35. doi: 10.1038/s41572-019-0086-z. PMID: 31123267
Histology of Barrett's Metaplasia: Do Goblet Cells Matter?
Odze R
Dig Dis Sci 2018 Aug;63(8):2042-2051. doi: 10.1007/s10620-018-5151-z. PMID: 29998421
Endoscopic findings of esophagogastric junction in children.
Nakayama Y, Ida S
Dig Endosc 2017 Apr;29 Suppl 2:11-17. doi: 10.1111/den.12793. PMID: 28425652
Advances in understanding the pathogenesis of Barrett's esophagus.
Clemons NJ, Koh SY, Phillips WA
Discov Med 2014 Jan;17(91):7-14. PMID: 24411696
Diagnosis of esophagogastric tumors.
Lambert R
Endoscopy 2004 Feb;36(2):110-9. doi: 10.1055/s-2004-814178. PMID: 14765308

Clinical prediction guides

Histology of Barrett's Metaplasia: Do Goblet Cells Matter?
Odze R
Dig Dis Sci 2018 Aug;63(8):2042-2051. doi: 10.1007/s10620-018-5151-z. PMID: 29998421
Origins of Metaplasia in Barrett's Esophagus: Is this an Esophageal Stem or Progenitor Cell Disease?
Zhang W, Wang DH
Dig Dis Sci 2018 Aug;63(8):2005-2012. doi: 10.1007/s10620-018-5069-5. PMID: 29675663Free PMC Article
Endoscopic findings of esophagogastric junction in children.
Nakayama Y, Ida S
Dig Endosc 2017 Apr;29 Suppl 2:11-17. doi: 10.1111/den.12793. PMID: 28425652
The Complex, Clonal, and Controversial Nature of Barrett's Esophagus.
Evans JA, McDonald SA
Adv Exp Med Biol 2016;908:27-40. doi: 10.1007/978-3-319-41388-4_3. PMID: 27573766
Diagnosis of esophagogastric tumors.
Lambert R
Endoscopy 2004 Feb;36(2):110-9. doi: 10.1055/s-2004-814178. PMID: 14765308

Recent systematic reviews

Unsedated transnasal endoscopy for the detection of Barrett's esophagus: systematic review and meta-analysis.
Huibertse LJ, Peters Y, Westendorp D, Siersema PD
Dis Esophagus 2023 Jan 28;36(2) doi: 10.1093/dote/doac045. PMID: 35830873Free PMC Article
Systematic review and meta-analysis of the effectiveness of radiofrequency ablation in low grade dysplastic Barrett's esophagus.
Pandey G, Mulla M, Lewis WG, Foliaki A, Chan DSY
Endoscopy 2018 Oct;50(10):953-960. Epub 2018 Apr 24 doi: 10.1055/a-0588-5151. PMID: 29689573

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